Watchman News

A New Series of Health Insights Is on the Way

WAŻNY

A New Series of Health Insights Is on the Way

Our team has been working behind the scenes to prepare new research and practical health
strategies for our readers. While we finish preparing what’s coming next, we invite you to
explore one of the most-read articles from our library below. See exactly what’s changing →

I’m currently in the process of publishing a scientific paper and writing a book that takes a deep dive into liver health, including the overlooked root causes of liver dysfunction and what you can do to reverse them.

The fact is, liver disease has become one of the most overlooked public health threats of our time, quietly damaging the organs of millions of people who feel perfectly fine. You could be living with significant liver scarring and have no idea — until symptoms finally emerge, and by then, it’s often too late to reverse course. The real danger isn’t liver fat itself.

It’s the silent buildup of fibrosis — scar tissue that forms when your liver is repeatedly injured and doesn’t have a chance to heal properly. That scarring is what sets the stage for cirrhosis, organ failure, and cancer. This form of liver disease is fueled by common, everyday problems like insulin resistance, excess belly fat, and poor mitochondrial function.

New data published in medical journals show just how common advanced liver damage has become, especially in people over 50.1 What’s more concerning is that conventional lab tests won’t pick it up. You can have “normal” liver enzyme levels and still be progressing toward irreversible fibrosis. And if you have Type 2 diabetes, the risk is exponentially higher.

But you’re not powerless here. Researchers are sounding the alarm and pushing for new, noninvasive screening tools that catch this condition early. Plus, there are lifestyle changes to reverse the trajectory before your liver crosses the point of no return.

Most People at Risk for Liver Failure Are Never Told They Have It
A paper published in The Lancet Regional Health Europe outlined a major gap in liver disease care: most people with metabolic dysfunction-associated steatohepatitis (MASH) and fibrosis — what the researchers call “at-risk MASH” — don’t know they have it until it’s too late.2
The researchers called for doubling diagnosis rates by 2027, warning that without early detection, millions could progress to irreversible cirrhosis or liver cancer. They focused on expanding diagnostics beyond liver specialists and shifting testing into primary care, where the highest-risk patients are already being seen regularly.

• Older adults with diabetes or obesity are most affected — The study highlighted that MASH with moderate to advanced fibrosis is particularly common in people over age 50 and those living with Type 2 diabetes or obesity.

In these groups, the disease often advances without noticeable symptoms, leading to missed opportunities for prevention. By the time these individuals receive a diagnosis — often triggered by unrelated imaging or advanced symptoms — the window for full recovery has usually closed.

• Current diagnostic systems are outdated and missing early-stage disease — Right now, liver disease is often diagnosed using liver enzymes like alanine aminotransferase (ALT) and aspartate aminotransferase (AST), but the cutoffs are too high and outdated.

According to the paper, many labs still use upper limits that miss early fibrosis. The researchers suggested lowering the thresholds to align with more modern standards of ALT greater than 33 IU/L for men and greater than 25 IU/L for women.

However, in my interview with Dr. Bryan Walsh, a naturopathic physician extensively trained in molecular biological pathways and an associate professor at the University of Western States, he explains that the medical literature “very clearly show that, a) men and women should have a different AST and ALT reference range, and b), [the ideal range] is not much above 20 U/L.”

• Primary care providers are missing clear opportunities to screen — People with cardiometabolic diseases, including prediabetes, obesity, and Type 2 diabetes, typically have frequent doctor visits, which represent missed chances to test for liver fibrosis. The paper recommends using these visits to incorporate routine screening tools into electronic health records. The goal is to make liver checks as common as blood pressure, cholesterol, or A1C testing.

Liver Scarring, Not Fat, Is What Puts You at Risk

While fat in the liver (steatosis) has been the main diagnostic target for decades, The Lancet Regional Health Europe paper emphasized that fibrosis stage — not fat content — is the main predictor of death or progression to cancer.3 Moderate fibrosis marks the point at which your liver begins losing function. Once fibrosis reaches more advanced stages or cirrhosis, the damage is harder — sometimes impossible — to reverse.

• Fibrosis silently progresses due to chronic metabolic dysfunction — The researchers explained that chronic inflammation caused by insulin resistance, toxic fat buildup, and oxidative stress leads to scar tissue forming in the liver. Over time, this scarring disrupts blood flow, stiffens tissue, and triggers a cascade of dysfunction that affects your entire body, from your metabolism to your immune system.

• The earlier fibrosis is found, the more reversible it is — Fibrosis at the minimal scarring stage can often be reversed through diet, lifestyle, and targeted therapies if caught in time. But once fibrosis progresses beyond this point, reversing the damage becomes far more difficult, even with aggressive treatment. Early detection isn’t just helpful — it’s necessary for meaningful recovery.

How Words Affect Whether People Seek Liver Care

An analysis published in Nature Medicine examined how stigma, especially surrounding alcohol use, prevents people from seeking timely diagnosis and treatment for liver disease.4 The authors argued that outdated language, including clinical labels like “alcoholic cirrhosis,” is not only inaccurate but actively harmful. They proposed new person-first terminology that emphasizes health status over blame, with the goal of improving care access and patient engagement.

• Patients delay or avoid care because of shame tied to the disease label — Researchers found that patients with liver conditions often experience guilt, internalized shame, and discrimination from health care providers and insurers, especially when their disease is linked to alcohol. Even people with metabolic liver conditions like MASH, who don’t drink heavily or at all, often fear judgment and delay seeking help. This contributes to late-stage diagnoses and reduced survival.

• Language influences medical bias, policy, and treatment decisions — The paper showed that stigmatizing language has real consequences in care delivery. People with liver disease often receive worse care, are deprioritized for transplants, and face lower-quality pain management simply due to the perceived behavioral causes of their illness. This bias also extends into health care funding and policy, reinforcing a cycle of neglect.

• Reframing liver disease in human terms helps improve outcomes — Instead of labels like “alcoholic” or “fatty liver,” the authors recommend phrases like “person with steatotic liver disease” or “individual managing MASH.” These terms reduce identity-based judgment and shift the focus toward solutions and support. Just as cancer and mental health advocacy have benefited from reframing language, liver care should follow the same path.

• The researchers called for broad changes in global disease classification systems — According to the paper, global coding systems like the International Classification of Diseases still use outdated and stigmatizing terms, reinforcing harm at every level of care. By updating these systems to reflect person-first, nonjudgmental language, health care providers could help increase early screening, reduce treatment delays, and improve survival rates.

Most People with Liver Damage Don’t Know Until It’s Advanced

A 2023 narrative review published in Cureus similarly focused on the silent progression of chronic liver disease and the urgent need for earlier screening, especially in people with metabolic risk factors.5 The paper highlighted how the liver sustains ongoing damage for years without causing symptoms, making early intervention difficult. As a result, many people only get diagnosed when they develop cirrhosis or complications like fluid retention, confusion, or internal bleeding.

• Patients typically remain undiagnosed until severe symptoms appear — Researchers noted that early signs, like fatigue, mild abdominal discomfort, or bloating, are either too vague or too easily dismissed, both by patients and providers. This is especially dangerous for people with underlying metabolic conditions, such as insulin resistance or obesity, who are already at higher risk.

• Common liver disease triggers were categorized into four main types — The review grouped liver disease into four overlapping causes: alcohol use, hepatitis viruses, fatty liver related to metabolic dysfunction, and autoimmune or genetic disorders. In real life, many of these overlap. A person might have mild alcohol intake and also be overweight or diabetic, which accelerates progression. This complexity is part of why the disease goes undetected — it doesn’t follow one clear path or profile.

• Researchers identified the biggest diagnostic blind spots in clinical care — Despite known risk factors, physicians rarely screen for liver fibrosis unless liver enzymes are elevated or symptoms appear. But, as mentioned, liver enzyme tests are often normal in the early stages, so fibrosis silently continues. The review emphasized that relying on enzymes alone is a flawed approach. Noninvasive imaging and biomarker tests are far better tools for early-stage detection.

• Cutting-edge diagnostics are emerging, but underused — The paper introduced newer testing methods gaining ground in research and clinical practice, including elastography — a type of ultrasound that measures liver stiffness — microRNA markers, and polygenic risk scores. These tools catch liver damage before symptoms arise, especially in people with metabolic dysfunction. However, access and awareness remain low, particularly outside specialist settings.

People with Diabetes Are at the Center of the Liver Disease Epidemic

According to the American Diabetes Association (ADA), about 7 out of 10 people with Type 2 diabetes have some degree of fat buildup in their liver.6 Even more concerning, nearly 1 in 5 already have hidden scarring, which often leads to cirrhosis if left untreated.

• Doctors are being urged to start checking liver health like they check blood sugar — The ADA recommends a simple two-step screening process that starts with a blood test called the fibrosis-4 index (FIB-4). If that’s high, it should be followed by a scan that checks how stiff your liver is. This reveals early signs of liver damage before symptoms ever show up.

• Liver disease in diabetes affects your whole body, not just your liver — When liver damage progresses, it raises your risk for heart disease, kidney problems, cancer, and even early death. People with both diabetes and liver disease are even more likely to die early compared to those without either condition.

• Catching liver issues early gives you the best shot at recovery — The good news is that liver scarring is often reversible — if you catch it in time. Simple lifestyle shifts, like cutting out harmful oils, losing belly fat, and improving your diet, can go a long way toward stopping the damage before it turns into something more serious.7

How to Stop Liver Disease Before It Starts

If you’ve been told your liver enzymes are “a little high,” if you’re dealing with Type 2 diabetes or stubborn belly fat, or if you’re over 50 and have never had your liver checked — now’s the time. The earlier you act, the better your odds of reversing liver scarring and preventing cirrhosis or cancer down the road. Liver disease doesn’t show up on your radar until it’s advanced, but the damage begins years earlier. I want you to be ahead of it. Here’s how:

1. Cut out vegetable oils and alcohol immediately — If you’re eating packaged foods made with soybean oil, canola, corn oil, or anything that says “vegetable oil,” your liver is under attack. These oils are high in linoleic acid (LA), a mitochondrial poison that disrupts cellular energy, promotes fat accumulation in your liver and drives inflammation. Toss out the junk and cook with butter, tallow, ghee, or coconut oil instead.

Cutting back on alcohol is just as important as eliminating vegetable oils. Both alcohol and polyunsaturated fats like LA overwhelm your liver in similar ways. When your body metabolizes vegetable oils, they turn into toxic byproducts called oxidized linoleic acid metabolites, or OXLAMs. These are a type of reactive aldehyde — unstable, highly damaging molecules that disrupt cell membranes and set off chronic inflammation.

Alcohol does something very similar. It’s broken down into acetaldehyde, another reactive aldehyde that harms your mitochondria and accelerates aging at the cellular level. Both types of aldehydes interfere with your liver’s ability to detoxify, regenerate, and store energy. If you already have signs of insulin resistance, belly fat, or elevated liver enzymes, avoiding both vegetable oils and alcohol gives your body the best chance to reverse the damage before it becomes permanent.

2. Add choline-rich foods to help your liver move fat out before it causes damage — Choline is essential for clearing fat from your liver. Without enough of it, fat starts to pile up in your liver cells, eventually leading to inflammation and scarring. Think of choline as the nutrient that keeps your liver’s traffic flowing — without it, everything gets backed up.

The best food source is pastured egg yolks, but be sure to look for low-PUFA eggs. Grass fed beef liver is another option that delivers a highly absorbable form of choline. Choline isn’t optional — it’s required for making phosphatidylcholine, a molecule your liver needs to package and export fats. Without it, those fats get stuck, and that’s when the damage begins.

3. Consider a choline supplement if your diet falls short — If you avoid animal products, getting enough choline becomes a real challenge. Plant-based sources like cruciferous vegetables offer only small amounts, and you’d need to eat unrealistic quantities to meet your needs. In that case, a supplement isn’t just helpful — it’s often necessary to avoid deficiency.

One underrated option is citicoline, a form of choline that’s been largely overlooked because most products use doses that are far too low to have a real effect. But at therapeutic levels — between 500 milligrams (mg) and 2,500 mg per day — citicoline supports your liver’s ability to export fats, while also helping your brain make acetylcholine, a key neurotransmitter. If you’re dealing with liver stress, insulin resistance, or brain fog, this is a smart addition to your routine.

4. Move every day and keep your waist in check — I’m not talking about running marathons. Just take a brisk walk after meals, stretch, and do a bodyweight circuit a few times a week. The goal is to keep insulin low and blood flowing through your liver. If your waist is over 40 inches (men) or 35 inches (women), focus on trimming visceral fat — it’s the type that’s directly tied to liver scarring.

FAQs About Liver Disease

Q: What makes liver fibrosis more dangerous than liver fat?

A: Liver fat is often reversible, but fibrosis — scarring caused by repeated liver injury — is what drives disease progression. It disrupts liver function, impairs detoxification, and raises your risk of cirrhosis, liver failure, and cancer. Fibrosis, not fat, is the key predictor of poor outcomes.

Q: Why do so many people with liver disease go undiagnosed?

A: Liver disease typically causes no symptoms until it’s advanced. Standard blood tests, like ALT and AST, often miss early fibrosis because the cutoff values are outdated. Many people have “normal” labs despite having significant liver scarring. New research calls for noninvasive tests and earlier screening, especially in those over 50 or with Type 2 diabetes.

Q: How are vegetable oils and alcohol connected to liver damage?

A: Both vegetable oils (high in LA) and alcohol create toxic byproducts called reactive aldehydes when metabolized — OXLAMs from vegetable oils and acetaldehyde from alcohol. These compounds damage mitochondria, disrupt detox pathways, and accelerate liver scarring. Eliminating both is key to recovery.

Q: What nutrients help my liver clear out fat?

A: Choline is essential. It helps your liver package and export fat so it doesn’t get trapped and cause inflammation. Pastured, low-PUFA egg yolks and grass fed liver are rich sources. If you’re not eating these foods, citicoline supplements (500 mg to 2,500 mg daily) help restore choline levels and support both liver and brain health.

Q: What’s the best way to start reversing liver scarring?

A: Begin by cutting out vegetable oils and alcohol completely. Add choline-rich foods like pastured egg yolks or supplements, move your body daily to reduce insulin resistance, and trim belly fat. These steps reduce the metabolic stress that drives liver scarring and give your liver the space it needs to heal.

Is your ability to process large amounts of information falling behind these days? Are your reaction times slowing down? If you think that this is just part of aging, you’re wrong. According to newly published research, it’s possible that you’re just not getting enough resistance exercise.

The solution? Making weightlifting a part of your health routine. Based on the findings of a recent study, even a single session is enough to make your brain sharper than before.

Resistance Exercise Spurs You to Think Faster Immediately

A study published in Psychophysiology investigated how a single session of moderate-intensity resistance exercise affects your ability to think quickly and stay mentally sharp. Participants were 121 healthy adults between 18 and 50 years old who had no neurological disorders or major health concerns that would interfere with exercise or cognition.1

After a supervised workout that used common resistance exercises at moderate intensity, the participants completed two computerized tests — one that measured inhibitory control and another that tested working memory. The researchers tested how one workout could already shift both behavior and brain signaling in ways that strengthen executive function, which includes skills like staying focused, resisting distractions, and switching between tasks.

• The findings were immediate — Reaction times improved after the resistance session, while accuracy stayed the same. In other words, the participants’ brains thought faster without making more mistakes. This shows that even a single session is enough to sharpen your thinking for tasks you do the same day.

If you face busy work schedules, intense study sessions, or complex projects, starting your workout session earlier in the day to aid in mental performance afterward can be a viable strategy.

• A detailed look at the data — The researchers reported that reaction time on the inhibitory control test improved with an effect size (the magnitude of the difference between groups2) of 0.37, which they described as a moderate improvement in processing speed. That means the workout didn’t only make people feel more alert — they responded faster when the task required them to ignore irrelevant information or manage competing cues.

The working-memory task showed an even larger improvement in reaction time, with an effect size of 0.46, reinforcing the idea that resistance exercise supports quicker mental operations across different executive skills.

• The study explored changes in brain activity, focusing on a signal called the P3 component — This is an electrical marker your brain produces when it evaluates and updates information. The authors noted that after resistance exercise, P3 latency significantly decreased during the inhibitory-control task.

A shorter P3 latency means the brain completed its information-processing step quicker. Since this shift appeared only after exercise and not after rest, it highlights a clear connection between the workout and faster neural timing.

• How the body’s physical responses influenced mental changes — The researchers measured systolic blood pressure and blood lactate, which are two biomarkers that naturally rise during resistance exercise. Their analysis showed that systolic blood pressure partially mediated the relationship between the workout and faster reaction times.

In other words, the temporary rise in blood pressure helped explain why people processed information faster. But this isn’t a sign that high blood pressure is good — it means the normal, short-term increase during exercise help push more oxygen-rich blood to the brain, enabling quicker thinking when the task demands it.

• Comparisons between the different physiological measures also revealed interesting findings — While both lactate and systolic blood pressure increased after exercise, only systolic blood pressure explained part of the cognitive improvement.

Lactate rose sharply — as expected after resistance training — but did not mediate any cognitive benefits. However, the researchers noted that it serves another purpose, which is fuel. In fact, they noted that it supports “up to 75% of the brain’s oxidative metabolism, and acting as an additional fuel source.”

• Improvements appeared across all healthy participants tested — However, the authors did emphasize that faster processing happened without any drop in accuracy, which matters because many activities in daily life require both speed and precision.

Even the Youth Gain Cognitive Benefits from Resistance Exercise

According to a meta-analysis published in Sports Medicine, resistance training positively affects thought processes and school performance in children and teenagers. The researchers pooled together 53 intervention studies and an additional 43 association studies, giving the authors a broad view of how strengthening the body influences the developing brain.3

Participants were school-aged youth between 5 and 18 years old from diverse backgrounds, school systems, and fitness levels. The exercise programs evaluated in the meta-analysis ranged from basic bodyweight routines to structured weightlifting sessions performed two to three times per week.

• The children gained cognitive benefits from weightlifting — Across the reviewed studies, resistance training consistently supports improvements in thinking skills, on-task classroom behavior, and general academic outcomes. The authors described the overall effect as “a small, positive effect on the combined outcomes of cognition, academic achievement, and on-task behaviour in school-aged youth.”

• The rate of improvement across academic-related outcomes showed up clearly in focused-strength programs — When resistance training was the primary intervention, the effect size increased to 0.26, meaning these programs promoted sharper thinking and better academic behaviors more than mixed exercise programs.

• The review also distinguished what improved most — The clearest gains surfaced in “on-task behavior” category, which reflects how well students stay engaged during lessons rather than drifting off or being distracted.

Even small boosts in on-task behavior translate into more learning absorbed per class period, smoother classroom flow, and less frustration for both students and teachers.

• Benefits are apparent right away — Many of the reviewed studies lasted only a few weeks, yet the authors already found measurable improvements in cognitive and academic outcomes. This means that short programs can already drastically benefit students within school timeframes, provided that educators can reasonably implement them.

• Some groups of participants appeared to gain more than others — Programs that targeted children with lower baseline muscular fitness produced more pronounced improvements in cognitive outcomes. As such, improving muscular strength for kids with school problems allows them to break through both physical and cognitive barriers at the same time.

• Strength training alone is more than enough to create cognitive benefits — The review also compared variables across studies to determine which exercise components mattered most. The authors found that resistance training alone produced clearer benefits than concurrent training, where strength and aerobic exercise were combined.

• The hypothesis stands up even when the research parameters were widened — The researchers also included 43 association studies, which showed that young people with higher muscular fitness scores have better cognitive performance and higher academic achievement overall.

While these studies cannot confirm cause and effect, the pattern was strong enough to support a clear link between stronger bodies and sharper minds.

• The theory behind the benefits — The review did not include an analysis of biological mechanisms, but the researchers did outline a hypothesis. Based on the reviewed literature, resistance training facilitates neurogenesis, resulting in improved executive function.4

Strength Training Tips for Beginners

It’s tempting to go all-out so you can gain the cognitive benefits of resistance training right away. However, this is a mistake that many beginners make, as more isn’t always better, especially when it comes to exercising. In fact, overdoing it actually shortens your lifespan.

• Optimal longevity returns top out at about 40 to 60 minutes of lifting per week — In my interview with Dr. James O’Keefe, a cardiologist with the Mid-America Heart Institute at St. Luke’s Hospital in Kansas City, he showed me his research5 that pushing yourself too hard in the gym can actually work against you, especially when high-intensity training becomes excessive.

O’Keefe’s data reveals a J-shaped relationship between weekly strength training and overall mortality — benefits rise up to roughly 40 to 60 minutes per week, then level off, and eventually start to decline.

• Why excess training shortens your lifespan — Long sessions of strenuous weightlifting put the body under continuous strain. Over time, this contributes to problems like heart stress, overuse injuries, and a greater likelihood of joint or muscle damage. Overtraining also hampers your ability to recover, leading to persistent fatigue, lower performance, and a weakened immune system.

• More than two hours a week cancels out the gains — Strength training for a total of 130 to 140 minutes of each week erases the longevity edge that exercise is supposed to offer. In other words, if you spend three to four hours lifting weekly, your long-term survival outcomes look no better compared to people who do not lift at all.

• Too much lifting may be worse than doing nothing — While vigorous activity is generally healthier than total inactivity, excessive strength training is an exception. For reasons still not fully understood, going overboard with heavy, high-intensity workouts can leave you in a worse position than staying sedentary.

• Stick to 20 minutes twice weekly and don’t overfocus on lifting — The training takeaway here is simple. Keep strength sessions short and spaced out. Aim for about 20 minutes two times per week on nonconsecutive days, or a single 40-minute session. Think of strength work as a supplement to your routine, not its foundation. Moderate activities like walking deliver far broader longevity benefits.

• Even brief weekly sessions support healthy aging — If you’re having a hard time finding a consistent schedule, even lifting weights weekly is enough to boost your health. This modest level of training is consistent with research6 from Brigham Young University, showing that small weekly doses — as little as 10 to 50 minutes — can positively influence telomere length. In other words, just a little, regular strength work can help slow biological aging without exposing you to the risks of overtraining.

To learn more about the benefits of weight training for older adults and how to incorporate it into your workout routine, read “Strength Training Turns Back the Clock on Your Biological Age.”

Experiment by Incorporating Blood Flow Restriction Training

Resistance exercise already does a great deal for your overall health, and you can amplify its effects further with one simple tweak — wrapping bands around your limbs as you work out. This approach, called blood flow restriction (BFR) training — or KAATSU in Japan — involves partially limiting circulation to the arms or legs during exercise.

• How KAATSU works — Cyclical restriction of blood flow during resistance exercise stimulates the release of anti-inflammatory myokines that promote muscle growth. This is especially valuable for older adults who want to maintain strength without lifting heavy weights. Steven Munatones, a leading figure in the KAATSU community, describes the mechanism this way:

“KAATSU cycle is basically a very clever biohack that will allow the muscles to work and allow the vascular tissue to become more elastic. You don’t perceive the pain of heavy lifting, but your vascular tissue and muscle fibers are being worked out just as effectively, and you can do it for a longer period of time.”

• Your bone mineral density also improves — Research published in Frontiers in Physiology7 found that participants who practiced BFR training three times per week over six weeks experienced improvements in bone formation markers, even while using low-intensity movements. “BFR resistance training was effective for stimulating acute bone formation marker and hormone responses,” they emphasized.

Another study8 mirrored these findings, which involved a group of inactive adolescent girls. Results showed that low-intensity BFR produced benefits comparable to high-intensity routines. Notably, it reduced levels of C-terminal telopeptide (CTX), a biomarker linked with bone breakdown.

• KAATSU can also fit into your daily routine — If you’re struggling to set time aside for regular workouts, you can use KAATSU wherever you go. Munatones notes that you can wear the bands while doing simple, daily activities:

“Putting the KAATSU bands on your legs and walking down to the beach, walking your dog or just walking around the neighborhood, standing, cleaning your windows of your house, folding your clothes, banging out emails, all of these things can be done with the KAATSU bands on your arms or legs. You’re getting the benefit of exercise.”

To learn more, check out my previous article, “How to Stay Fit for Life,” in which I review the science behind KAATSU and explain in greater detail how to use it.

The main difference between KAATSU and BFR is the tool you’re using. BFR can be done with restriction bands, but KAATSU uses a device that also provides intermittent and not just constant pressure. The KAATSU set is ideal as it is far easier to dial in to the correct pressures. You also get the benefit of intermittent pressure automatically, without having to adjust the bands yourself.

I recommend the C4 model, because the C-series doesn’t have Bluetooth (which emits harmful electromagnetic fields). For a limited time, you can get 10% off any KAATSU equipment by using the promo code DRM.

> > > > > Click Here

Editor’s Note: This article is a reprint. It was originally published April 14, 2024.

Over the past decade, I’ve written many articles discussing the evidence of biological harm from non-ionizing electromagnetic field (EMF) radiation and radiofrequency radiation (RFR) from wireless technologies.

The video above features an interview I did with Siim Land in February 2020 for his Body Mind Empowerment podcast in which I discuss EMF — what it is, your greatest sources of exposure, how it affects your biology, and how to minimize your exposure. I also review how the telecommunications industry manipulates the truth to keep you unaware of the hazards.

While the wireless industry is built on the premise that the only type of radiation capable of causing harm is ionizing — X-rays being one example — researchers have for a long time warned that even non-ionizing and non-heating radiation can jeopardize your health. This includes not only human health, but also that of plants and animals.

Over time, I became so convinced of the deleterious effects of EMF, I took three years to write “EMF*D” which was published in 2020. In it, I reviewed the overwhelming evidence showing EMFs are a hidden health hazard that simply cannot be ignored any longer.

During the pandemic, we also witnessed the rollout and installation of 5G across the country, which has exponentially increased exposures, as it’s added on top of the already existing wireless infrastructure.

The short video below, published by Investigative Europe in January 2019, gives a quick overview of how 5G differs from previous wireless technology. At the time, little if any research had been done on 5G specifically, but between 2022 and 2024, 10 studies have been published that shed more light on this fifth-generation technology.1

5G Appeals for Moratorium Ignored Despite Evidence

The first of these, published in September 2022 in the journal Reviews on Environmental Health,2 provides a good overview of the hazards 5G poses. The authors pointed out that, since September 2017, over 400 scientists and doctors have collectively submitted six appeals to the European Union, calling for a moratorium on 5G technology. All have been ignored.

The September 2021 appeal included an “extensive cover letter” in which experts argued that the EU’s reliance on guidelines by the International Commission on Non-Ionizing Radiation Protection (ICNIRP) places public health at risk because the guidelines only consider “heating and no other health relevant biological effects from RFR.”

The letter countered the ICNIRP’s guidance with research from European and international expert groups detailing myriad adverse biological effects of RFR on humans and the environment. According to the authors:3

“Evidence to establish this position is drawn from studies showing changes to neurotransmitters and receptors, damage to cells, proteins, DNA, sperm, the immune system, and human health, including cancer.

The 2021 Appeal goes on to warn that 5G signals are likely to additionally alter the behavior of oxygen and water molecules at the quantum level, unfold proteins, damage skin, and cause harm to insects, birds, frogs, plants, and animals.”

Aggregation of Signals Pose Serious Concerns

Under the subhead “Great Plans, Great Promises but False Claims,” the authors go on to highlight the government’s own findings:

“… the potential health and safety risks associated with RFR have been exposed in a recent EU-commissioned review of the currently available scientific evidence, the 2021 European Parliamentary Research Service’s EPRS/STOA Health impact of 5G report.4

The conclusions of the comprehensive review declared sufficient evidence for cancer from RFR in animals, sufficient evidence for adverse effects from RFR on the fertility of men, male rats and mice, and that RFR is probably carcinogenic to humans.

In short, the EPRS/STOA report shows that RFR is harmful for health. The report subsequently calls for measures to incentivize the reduction of RF-EMF exposures (p. 153), such as lowering the limit for allowed exposures and the preferential use of wired connections.

Similarly, the EU’s own (ITRE committee) 2019 in-depth analysis, 5G Deployment: State of Play in Europe, USA, and Asia5 warned that, when added to 2G, 3G, 4G, WiFi, WIMAX, DECT, radar etc., 5G will cumulatively lead to dramatically more total radiation: not only from the use of much higher frequencies in 5G but also from the potential for the aggregation of different signals, their dynamic nature, and the complex interference effects that may result, especially in dense urban areas (p 11).

These concerns are based on the complexity of communications signals and the unknowns of their interactions. Electromagnetic signals transmitted by manmade communication devices are not regular waves; rather, they are a complex combination of ultra-high frequency carrier waves, and modulations that encode the messages using extremely-low and ultra-low frequencies.

In addition, the signals are pulsed at ultra-low frequencies (sent in short on-off bursts). This means that although the RFR carrier waves may sit in the high frequency GHz range, their modulations and pulse rates are much closer to brain-wave frequencies; e.g., the 217 Hz pulsing of a GSM phone signal.

Pulsed or modulated RFR signals have been shown to be more bio-active than simple continuous waves of the same intensity and exposure duration. This is of significant concern in relation to public health and is not limited to just the higher 5G frequencies.

Furthermore, as the report noted, the effects of these new complex beam formed signals have unpredictable propagation patterns that could result in unacceptable levels of human exposure to electromagnetic radiation (p. 6) but are yet to be mapped reliably for real situations, outside the laboratory.”

5G Causes Neurological and Psychiatric Problems

The second study,6 published in November 2022, investigated the effects of 4.9 GHz (one of several 5G frequencies) RFR on the emotional behaviors and spatial memory in adult male mice. The exposure was found to induce “depression-like behavior” caused by “neuronal pyroptosis in the amygdala.”

Pyroptosis is a form of programmed cell death distinct from other forms of apoptosis, characterized by its inflammatory response. It involves the swelling and bursting of the cell, leading to the release of proinflammatory cytokines and intracellular contents that can trigger an immune response in the surrounding tissue.

This process is controlled by gasdermin proteins, which form pores in the cell membrane, and is often initiated in response to infections by pathogens or other signals indicating cellular damage.

5G induces cell death in the amygdala, a region of the brain involved in emotion regulation, memory, and decision-making.

The amygdala is a region of the brain involved in emotion regulation, memory, and decision-making. So, pyroptosis in this area could be indicative of neurological damage or inflammation, affecting emotional regulation, behavior, and cognitive functions.

This could be relevant in the context of neurodegenerative diseases, brain injuries or infections that impact the central nervous system, leading to various neurological and psychiatric implications.

4 Studies Confirm 5G’s Impact on Neurology

Another four studies published in 2023 also show a variety of damage occurring in the brain:

• 5G increases permeability of the blood-brain barrier7 — In the first, RFR from 5G cellphones at 3.5 GHz or 4.9 GHz for one hour per day for 35 days straight was found to increase the permeability of the BBB in the cerebral cortex of mice.

• RFR impairs neurogenesis and causes neuronal DNA damage8 — In the second, continuous RFR from cellphones at 2115 MHz for eight hours was shown to induce higher levels of lipid peroxidation, carbon-centered lipid radicals, and single-strand DNA damage, resulting in impaired neurogenesis in the hippocampal region and neuronal degeneration in the dentate gyrus region.

Translation: Cellphone radiation causes cognitive impairment and deficits, behavioral changes and dysfunctional mood regulation, neurodegenerative disorders (due to the oxidative stress within neurons) and psychiatric conditions such as anxiety and depression.

• Electromagnetic radiation associated with anxiety9 — This study found anxiety-like behavior in male mice exposed to electromagnetic radiation at 2650 MHz for four hours a day for 28 days.

• 5G may promote dementia10 — Lastly, a follow-up study on previous research concluded that RFRs at 1.8 GHz to 3.5 GHz:

◦ Inhibit neurosin, an enzyme that plays a role in brain health, including the breakdown of proteins that, if not properly managed, could lead to conditions like Alzheimer’s disease. This finding suggests that cellphone radiation could interfere with the brain’s ability to prevent the buildup of harmful proteins.

◦ Inhibit the electrical activity of neurons in vitro — Neurons communicate with each other using electrical signals and this activity is crucial for everything your brain does, from processing sensory information to controlling muscle movements. Inhibiting electrical activity means disrupting normal brain cell communication, which could impact brain functions.

5G Affects Brain Development

An October 2023 study11 by Bodin et al. investigated the effects of exposure to 5G during the perinatal period — around the time of birth — on the neurodevelopment of rats. The main goal of this study was to explore how being exposed to 5G EMF around the time of birth affects the brain development of rats as they grow into juveniles and adolescents.

Both male and female rat pups exposed to 5G EMF showed delayed incisor (front teeth) eruption. This indicates that EMF exposure could slow down certain aspects of physical development. The study also found notable differences in behavior based on the sex of the rats.

In adolescent female rats, there was a significant reduction (70%) in stereotyped movements, such as repetitive patterns of behavior, in the open field test. This suggests that exposure may reduce certain repetitive behaviors in females. In contrast, male rats exhibited a 50% increase in stereotyped movements, indicating that the same exposure led to an increase in repetitive behaviors.

In short, the research suggests that exposure to 5G EMF at levels below the regulatory threshold during a critical period of development (perinatal period) has the potential to cause disturbances in neurodevelopment. These effects are seen in juvenile and adolescent descendants and manifest differently in males and females.

While it’s difficult to predict what the human health implications of this might be, it’s worth noting that repetitive behaviors are often associated with neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). In such cases, these behaviors may signal underlying neurological differences and can impact an individual’s social interactions, learning, and daily functioning.

In some instances, repetitive behaviors can also be symptomatic of anxiety, obsessive-compulsive disorder (OCD), stress-related disorders, and self-harming behaviors such as skin picking or hair pulling. For some individuals, repetitive behaviors can interfere with attention and focus, affecting academic performance, workplace productivity, and the ability to complete daily tasks efficiently.

It can also affect an individual’s social interactions and relationships, and can lead to social isolation, bullying, or stigma, particularly in children and adolescents, further impacting emotional well-being and self-esteem. Repetitive behaviors, particularly those associated with anxiety or compulsive disorders, can also disrupt sleep patterns, leading to insomnia or poor sleep quality, which in turn affects overall health and well-being.

RFR Decimates Male Fertility — Melatonin Can Help Restore It

A December 2023 study,12 which explored the negative effects of long-term exposure to 2100 MHz RFR on rat sperm characteristics, brought both good and bad news.

On the downside, male rats exposed to RFR at 2100 MHz for 30 minutes a day had a significantly higher percentage of sperm with abnormal shapes. There was also a significant reduction in the total sperm count among the exposed rats.

At a more detailed level, examining the sperm structure under a microscope (the ultrastructural level), damage was observed in critical parts of the sperm, including the:

Acrosome, a cap-like structure that helps the sperm penetrate an egg
Axoneme, the central shaft of the sperm tail
Mitochondrial sheath, which powers the sperm tail’s movement
Outer dense fibers, which are part of the sperm tail

The good news is that melatonin supplementation was able to prevent these problems. Rats given 10 milligrams of melatonin per kilo of bodyweight via subcutaneous administration had increased sperm counts and the proportion of sperms with normal shapes increased. Moreover, the ultrastructural damage to sperm caused by RF exposure was fully reversed. As reported by the authors:

“The percentages of abnormal sperm morphology were significantly increased with RF exposure, while the total sperm count was significantly decreased … The number of total sperms, sperms with normal morphology increased, and ultrastructural appearance returned to normal by melatonin administration.”

Case Study of an 8-Year-Old Boy

In January 2024, Hardell et al. presented a case study13 of an eight-year-old boy experiencing severe headaches and other symptoms while attending a school located near a mobile phone tower equipped with 5G base stations.

The boy’s school is situated 200 meters away from a mobile phone tower with 5G base stations, with his classroom being 285 meters away. Soon after starting school, he began experiencing headaches, which were initially sporadic, not occurring every day or every week.

By autumn 2023, the boy’s headaches intensified, occurring daily and rated as a 10 on a 10-grade scale, where 0 signifies no discomfort and 10 indicates unbearable pain. He also experienced fatigue (rated 5) and occasional dizziness (rated 7), specifically while at school. At home, he occasionally had mild headaches (rated 2) that subsided relatively quickly.

In the autumn of 2023, he started wearing an RF-protective cap and outerwear at school, both indoors and outside, after which the headaches vanished.

This paper also cites epidemiological studies and laboratory research linking RF radiation exposure to cancer through mechanisms such as oxidative stress, mRNA effects and DNA damage, and argues for classifying RF radiation as a Group 1 human carcinogen, noting that “This classification should have a major impact on prevention measures.”

5G Alters Your Microbiome

Lastly, a February 2024 study14 by Wang et al. examined the impact of 5G RFR on the fecal microbiome and metabolome profiles in mice. The results indicated that the mice exposed to RFR experienced significant alterations in their intestinal microbial compositions, characterized by a decrease in microbial diversity and shifts in the microbial community distribution.

Through metabolomics profiling, the researchers identified 258 metabolites that were significantly differentially abundant in the mice exposed to RF fields compared to controls, which suggests it can have a profound impact on metabolic processes.

The authors concluded that exposure to 4.9 GHz RFR can cause intestinal microbiota dysbiosis in mice and hypothesized that the observed imbalances in gut microbiota and metabolism might be linked to depression-like behaviors in mice seen in so many studies. The imbalance in the metabolic profile may also be associated with changes in immune regulation or inflammation.

5G Will Harm Every Living Being

In September 2019, the Minister for Communications, Hon. Paul Fletcher MP asked the Committee to complete an inquiry into the “deployment, adoption, and application of 5G in Australia.”15 In response, Paul Barratt, on behalf of ElectricSense, submitted a document, available as a download from aph.org, stating, in part:

“5G is dangerous and will harm every living being. Thousands of studies link low-level wireless radio frequency radiation exposures to a long list of adverse biological effects, including:

DNA single and double strand breaks
oxidative damage
disruption of cell metabolism
increased blood brain barrier permeability
melatonin reduction
disruption to brain glucose metabolism
generation of stress proteins

Let’s not also forget that in 2011 the World Health Organization (WHO) classified radio frequency radiation as a possible 2B carcinogen. More recently the $25 million National Toxicology Program concluded that radio frequency radiation of the type currently used by cell phones can cause cancer.

But where does 5G fit into all this? Given that 5G is set to utilize frequencies above and below existing frequency bands 5G sits in the middle of all this. But the tendency (it varies from country to country) is for 5G to utilize the higher frequency bands. Which brings its own particular concerns.”

Barratt goes on to list “11 reasons to be concerned about 5G radiation,” including:

Denser electrosmog
Skin diseases and pain, as “analyses of penetration depth show that more than 90% of the transmitted power is absorbed in the epidermis and dermis layer”16
Eye damage
Effects on the heart, including impacts on heart rate variability and arrhythmias
Reduced immune function
Depressed cell growth rates and alterations in cell properties and cell activity
Increased risk of antibiotic-resistant pathogens
Necrosis in plants, and the possibility that plant foods may become unsuitable for human consumption
Atmospheric effects and fossil fuel depletion
Ecosystem disruptions
Misleading 5G study results, as most do not pulse the waves. As noted by Barratt, “This is important because research on microwaves already tells us how pulsed waves have more profound biological effects on our body compared to non-pulsed waves. Previous studies, for instance, show how pulse rates of the frequencies led to gene toxicity and DNA strand breaks”

Protect Yourself and Your Family from Excessive EMF

There’s no doubt in my mind that RF-EMF exposure is a significant hazard that needs to be addressed if you’re concerned about your health. The rollout of 5G certainly makes remedial action more difficult, but the added hazards are all the more reason to get involved and do what we can to minimize exposure.

Here are several suggestions that will help reduce your EMF exposure and help mitigate damage from unavoidable exposures. For even more do’s and don’ts, see the infographic by the Environmental Health Trust below.

• Identify major sources of EMF, such as your cellphone, cordless phones, Wi-Fi routers, Bluetooth headsets, and other Bluetooth-equipped items, wireless mice, keyboards, smart thermostats, baby monitors, smart meters, and the microwave in your kitchen. Ideally, address each source and determine how you can best limit their use.

Barring a life-threatening emergency, children should not use a cellphone or a wireless device of any type. Children are far more vulnerable to cellphone radiation than adults due to having thinner skull bones.

Research17 also demonstrates that infants under the age of 1 do not effectively learn language from videos, and do not transfer what they learn from the iPad to the real world, so it’s a mistake to think electronic devices provide valuable education.

• Connect your desktop computer to the internet via a wired Ethernet connection and be sure to put your desktop in airplane mode. Also avoid wireless keyboards, trackballs, mice, game systems, printers, and portable house phones. Opt for the wired versions.

• If you need to use Wi-Fi, shut it off when not in use, especially at night when you’re sleeping. Ideally, work toward hardwiring your house so you can eliminate Wi-Fi altogether. If you have a notebook without any Ethernet ports, a USB Ethernet adapter will allow you to connect to the internet with a wired connection.

• Avoid using wireless chargers for your cellphone, as they too will increase EMFs throughout your home. Wireless charging is also far less energy efficient than using a dongle attached to a power plug, as it draws continuous power (and emits EMF) whether you’re using it or not.

• Shut off the electricity to your bedroom at night. This typically works to reduce electrical fields from the wires in your wall unless there is an adjoining room next to your bedroom. If that is the case, you will need to use a meter to determine if you also need to turn off power in the adjacent room.

• Use a battery-powered alarm clock, ideally one without any light.

• If you still use a microwave oven, consider replacing it with a steam convection oven, which will heat your food as quickly and far more safely.

• Avoid using “smart” appliances and thermostats that depend on wireless signaling. This would include all new “smart” TVs. They are called smart because they emit a Wi-Fi signal and, unlike your computer, you cannot shut the Wi-Fi signal off. Consider using a large computer monitor as your TV instead, as they don’t emit Wi-Fi.

• Refuse a smart meter on your home as long as you can, or add a shield to an existing smart meter, some of which have been shown to reduce radiation by 98% to 99%.18

• Consider moving your baby’s bed into your room instead of using a wireless baby monitor. Alternatively, use a hard-wired monitor.

• Replace CFL bulbs with incandescent bulbs. Ideally remove all fluorescent lights from your house. Not only do they emit unhealthy light, but more importantly, they will actually transfer current to your body just being close to the bulbs.

• Avoid carrying your cellphone on your body unless in airplane mode and never sleep with it in your bedroom unless it is in airplane mode. Even in airplane mode it can emit signals, which is why I put my phone in a Faraday bag.19

• When using your cellphone, use the speaker phone and hold the phone at least 3 feet away from you. Seek to radically decrease your time on the cellphone. Instead, use VoIP software phones that you can use while connected to the internet via a wired connection.

• Avoid using your cellphone and other electronic devices at least an hour (preferably several) before bed, as the blue light from the screen and EMFs both inhibit melatonin production.20,21

Research clearly shows that heavy computer and cellphone users are more prone to insomnia.22 For example, one 2008 study23 revealed that people exposed to radiation from their mobile phones for three hours before bedtime had more trouble falling asleep and staying in a deep sleep.

• The effects of EMFs are reduced by calcium-channel blockers, so make sure you’re getting enough magnesium. Most people are deficient in magnesium, which will worsen the impact of EMFs. As previously noted by EMF expert Dr. Martin Pall:

“When you’re deficient in magnesium, you get excessive activity of the VGCCs. You also get excessive calcium influx through the N-methyl-D-aspartate receptor, caused by magnesium deficiency, which is also problematic, so it’s important to allay that deficiency.”

• Pall has also published a paper24 suggesting that raising your level of Nrf2 helps ameliorate EMF damage. One simple way to activate Nrf2 is to consume Nrf2-boosting food compounds. Examples include sulforaphane-containing cruciferous vegetables, foods high in phenolic antioxidants, carotenoids (especially lycopene), sulfur compounds from allium vegetables, isothiocyanates from the cabbage group, and terpenoid-rich foods.

• Molecular hydrogen has been shown to target free radicals produced in response to radiation, such as peroxynitrites. Studies have shown molecular hydrogen can mitigate about 80% of this damage.25,26,27,28,29

Molecular hydrogen will also activate Nrf2, a biological hormetic that upregulates superoxide dismutase, catalase, and all the other beneficial intercellular antioxidants. This in turn lowers inflammation, improves your mitochondrial function and stimulates mitochondrial biogenesis.

> > > > > Click Here

Butyrate is a short-chain fatty acid (SCFA) produced in your gut when beneficial bacteria ferment dietary fiber that your body cannot digest on its own. As the primary energy source for colonocytes (the cells lining your colon), butyrate provides up to 70% of their energy needs.1

Butyrate directly nourishes the L-cells in your intestinal lining — the same cells that release GLP-1 after meals. GLP-1 is a hormone known for its role as a master regulator of metabolic health. It enhances insulin release after meals, suppresses glucagon, slows gastric emptying, and promotes satiety2,3,4,5 — all of which support blood sugar control and appetite regulation.

The butyrate–GLP-1 axis plays a key role in this natural system by fueling the L-cells that produce GLP-1. In addition to supporting GLP-1 signaling, butyrate also enhances energy expenditure by boosting fat oxidation and thermogenesis in brown adipose tissue.6,7 Animal studies reinforce these benefits: in mice fed a high-fat diet, butyrate supplementation significantly improved glucose metabolism and prevented weight gain.8

Pharmaceutical GLP-1 agonists attempt to mimic this effect, but your body already possesses a mechanism to produce GLP-1 on its own — provided L-cells receive sufficient fuel. Butyrate activates free fatty acid receptors on L-cells, which directly stimulate GLP-1 secretion.

Research shows that reduced butyrate availability leads to lower GLP-1 output, impaired insulin sensitivity, increased appetite, and greater fat accumulation.9 In this framework, obesity reflects a breakdown in microbial fuel delivery rather than a failure of calorie control alone. The steps needed to rebuild and support this natural mechanism is the central topic of my new book, “Weight Loss Cure; Melt Fat Naturally With Your Own GLP-1.”

How Butyrate Supports Your Body’s Built-In GLP-1 System for Weight and Mood

When butyrate is abundant, GLP-1 secretion follows the body’s original blueprint without external intervention:

• It slows gastric emptying, so you feel full longer
• It reduces glucagon, which lowers blood sugar
• It enhances insulin sensitivity and helps your body burn fat
• It sends satiety signals to the brain, curbing cravings and emotional eating
• It activates GLP-1 receptors in the brain, where it helps regulate mood, reduce anxiety, and support cognitive health

Butyrate and GLP-1 Are the Natural Design

Importantly, you don’t need a synthetic GLP-1 agonist to access these benefits. You need butyrate. This is how human metabolism was designed to work — not with synthetic shots, but with internal balance.

Your L-cells are engineered to release GLP-1 in response to butyrate. When the gut microbiome is balanced and well-fed with fermentable fiber, GLP-1 production activates after meals to regulate appetite, support insulin release, and promote fat burning — all without a prescription.

This design evolved to work in harmony with ancestral diets rich in whole foods, fiber, and unprocessed carbohydrates. Disruption to this design breaks the microbial fuel line, not the hormonal hardware.

When you restore butyrate production, you remove the blockages and reactivate the normal regulatory feedback loop, which lets your built-in weight regulation system function again, as intended. Whether you’re exploring medication options or want to support your body’s own systems, restoring butyrate production is foundational to how this hormone was designed to work.

How This System Gets Disrupted

Modern lifestyles disrupt this elegant mechanism. Seed oils, which are high in the omega-6 fat linoleic acid (LA), damage your gut lining and deplete butyrate-producing microbes. Low-fiber, high-sugar diets feed the wrong bacteria. Chronic stress and poor sleep reduce microbial diversity. All of this breaks the link between fiber, butyrate, and GLP-1. The result? Your natural weight regulation system goes offline.

Butyrate and GLP-1 Also Support Brain Health

Butyrate also helps regulate how your gut communicates with your brain, supporting the normal stress, immune, and mood responses your body was designed to manage.

As a key signaling molecule in the gut-brain axis, butyrate helps regulate the stress response, increase pain tolerance, and reduce neuroinflammation. It even crosses the blood-brain barrier, where it supports brain-derived neurotrophic factor (BDNF), boosts mitochondrial function, and protects against depression and cognitive decline.

GLP-1 is also more than a metabolic hormone. Like butyrate, it’s a brain-active compound.10 GLP-1 receptors are found in areas of the brain that govern memory, mood, and motivation. Activating them can reduce anxiety, blunt inflammation, and improve neuroplasticity.11,12

Together, butyrate and GLP-1 act as dual messengers — one produced by your gut microbes, the other released in response to it. They work in tandem to support the natural coordination of metabolism, immune function, and mental health, restoring the biological systems your body relies on to stay balanced.

How Butyrate’s and GLP-1 Inhibit Neuroinflammation

Neuroinflammation is widely recognized as a key factor in the development and progression of a wide range of neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis (MS).

A meta-analysis published in Neuroscience Letters,13 reports that butyrate supports brain health through multiple gut-brain mechanisms, particularly by strengthening mitochondrial function in the brain after fiber fermentation.

Butyrate suppresses major inflammatory pathways, most notably nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB),14 a master regulator of inflammation. In experimental models of Parkinson’s disease, beta-hydroxybutyrate reduced inflammation, protected neurons from endotoxin injury, and improved behavioral outcomes. By limiting NF-κB activity, butyrate lowers inflammatory cytokine release, which helps preserve synaptic function.

Butyrate also inhibits histone deacetylases (HDACs),15 which alters gene expression in brain cells. This epigenetic effect reduces pro-inflammatory signaling while increasing anti-inflammatory pathways, further calming neuroinflammation.16 In animal models of Alzheimer’s disease, butyrate lowered amyloid-beta plaque accumulation by up to 40% and supported cognitive performance.17

Butyrate-driven GLP-1 release adds another layer of protection. Preclinical research shows GLP-1 shields dopamine-producing neurons in Parkinson’s disease by lowering oxidative stress and supporting mitochondrial energy production.18 GLP-1 also promotes autophagy,19,20 which clears damaged proteins such as alpha-synuclein, and enhances insulin sensitivity and cellular energy metabolism in the brain,21 which is often impaired in Parkinson’s disease.

Butyrate, Mood, and the Gut-Brain Connection

Butyrate also influences mood and cognition by acting on key neurotransmitters, brain growth factors, and the vagus nerve. It enhances the production of gamma-aminobutyric acid (GABA) and dopamine22 — two crucial messengers that calm the nervous system and promote motivation and emotional balance. Low butyrate levels have been linked to anxiety and depression,23 in part due to disrupted gut-brain signaling.

As mentioned, it also boosts BDNF, a growth factor vital for learning, memory, and neuroplasticity.24,25 By inhibiting HDACs, butyrate increases BDNF in brain regions like the hippocampus, supporting neuron growth and reducing inflammation-driven damage.26 Low BDNF is a common feature in conditions like Alzheimer’s and major depression.27,28

Butyrate further strengthens the gut-brain axis by activating the vagus nerve — a communication superhighway that calms the body, lowers inflammation, and regulates neurotransmitters like serotonin and GABA.29 Increased vagal tone is associated with improved mood, better stress tolerance, and enhanced digestion, making butyrate a central player in emotional and cognitive health.30

How to Restore Butyrate Production in Your Gut

To restore your body’s natural weight management and mood regulation systems, you need to restore and support the bacteria in your gut that produce butyrate and other SCFAs. Here’s how:

1. Start with gut terrain repair — If you’re bloated, constipated, or sensitive to high-fiber foods, you need to calm inflammation before you feed the microbiome. That means:

• Avoiding fermentable fibers at first. When your gut is out of balance, high-fiber foods — even the “healthy” ones — can work against you. Foods like beans, lentils, oats and raw greens ferment quickly when the wrong bacteria are in control. This creates gas, pressure and inflammation, and worsens gut lining damage.
• Eliminating seed oils (such as soybean, corn, canola, sunflower). LA damages the exact gut microbes you’re trying to support. If your diet includes fried foods, processed snacks or sauces made with soybean, corn, sunflower, or canola oil, you’re suffocating your good gut bacteria. Replace those fats with ghee, grass fed butter, or tallow — fats your body actually knows how to use. The goal is to shift your internal terrain so your gut bacteria thrive again.
• Using simple carbs like white rice and ripe fruit to stabilize energy without feeding bad bacteria.

2. Reintroduce fiber in phases — Move on to fiber reintroduction only after you meet this criterion: You tolerate three consecutive days of white rice or ripe fruit with no bloating, abdominal pain, excess gas, or bowel urgency. At that point, introduce one resistant starch source at a time, starting with 1/2 cup cooked-and-cooled white potato once daily.

Once you can consume 1/2 cup cooked-and-cooled potato daily for seven consecutive days with no increase in gas, bloating, stool looseness, or abdominal discomfort, advance to inulin-rich foods such as garlic, onions and leeks. These fibers bypass digestion in your small intestine and head straight to your colon, where they fuel beneficial bacteria that make butyrate.

3. Support with optional tools — Once your gut begins to stabilize, these targeted tools can help accelerate butyrate production and improve results:

• Phase 1 — Akkermansia postbiotics — Postbiotics are non-living bacterial components that still deliver biological signals. Pasteurized forms of Akkermansia muciniphila contain Amuc_1100, a protein shown to tighten the gut barrier and reduce inflammation. Look for postbiotic formulas with enteric coating or microencapsulation to ensure they survive stomach acid and reach the colon intact.

Without that protection, less than 5% of Amuc_1100 reaches your colon. You could try megadosing to compensate, but that’s expensive and inefficient. Prioritize coated formats to support your gut barrier more effectively.
• Phase 2 — Live Akkermansia — Begin Phase 2 probiotics only after all of the following occur:

◦Bloating remains minimal or absent
◦Stool form stays consistent for at least 7 days
◦Fiber tolerance expands without symptom return

In this stage, introduce live probiotic Akkermansia alongside gentle prebiotics — like small amounts of resistant starch — to support the growth of butyrate-producing strains and reestablish a healthy, oxygen-sensitive microbial environment.

• Fermented foods — Raw sauerkraut, kefir, and other traditionally fermented foods can boost microbial diversity and support butyrate-producing strains. Go slowly — start with small amounts to test tolerance, especially if your gut is sensitive.

• Gut testing — A stool analysis can reveal which bacteria are present, whether your gut is inflamed, and how well you’re producing short-chain fatty acids like butyrate. This can guide food choices and supplementation more precisely.

• Resistant starch — Found naturally in cooked-and-cooled potatoes, green bananas, and legumes — or as supplemental powders — resistant starch bypasses digestion in the small intestine and becomes prime fuel for butyrate-producing bacteria in the colon.

4. Adjust your environment — Your gut doesn’t just respond to what you eat. It’s tuned into your entire lifestyle. These daily habits help create the internal rhythm your microbiome needs to thrive:

• Sleep — Align your sleep-wake cycle with natural light exposure. Aim for 7 to 9 hours of high-quality sleep and get morning sun to anchor your circadian rhythm. This helps regulate gut motility and microbial repair.
• Stress — Chronic stress alters your microbiome and shuts down butyrate production. Use daily tools like breathwork, walking outdoors, and nervous system regulation practices to calm your hypothalamic-pituitary-adrenal (HPA) axis and support microbial balance.
• Fasting window — Stop eating at least three hours before bed. This gives your migrating motor complex (MMC) — your gut’s internal clean-up crew — time to sweep out bacteria and food debris overnight, reducing fermentation and inflammation.

Signs Your Gut Is Making More Butyrate

The following improvements reflect rising butyrate levels and gut healing in real time:

• Bowel movements become regular and well-formed — A sign of improved colonic motility and mucosal integrity.
• Fiber tolerance improves — Less bloating, gas, or discomfort after meals rich in fermentable fiber.
• Hunger fades between meals — As GLP-1 and PYY production increases, satiety naturally extends.
• Mood feels more stable and stress less overwhelming — Butyrate supports BDNF and modulates the HPA axis.
• You lose fat without trying to eat less — Improved metabolic signaling leads to spontaneous caloric reduction.
• Reduced post-meal blood sugar spikes — A measurable effect tied to improved insulin sensitivity and GLP-1 response.
• Lower fasting insulin and triglycerides (if tested) — Both improve with SCFA restoration and microbiome balance.
• Fewer cravings for processed carbs and snacks — Satiety hormones rise while inflammation-driven hunger decreases.
• Less urgency or discomfort with bowel movements — Improved stool consistency reflects stronger gut barrier and reduced inflammation.
• Improved breath or reduction in sulfur/gas odors — Indicates better fermentation profile in the colon (fewer sulfur-releasing or proteolytic bacteria).

Track Your Progress: How to Know It’s Working

To track your recovery, keep a simple symptom journal for the first four to six weeks. Each day, jot down quick notes on these four markers:

• Bloating — None, mild, moderate, or severe
• Energy — Steady, sluggish, or crashing
• Mood — Calm, tense, irritable, anxious
• Bowel quality — Bristol stool scale (types 3 to 4 are ideal), frequency, urgency, discomfort

Even just a few words per day can help you see patterns clearly, especially when deciding when to add new foods or supplements. Once you begin reintroducing fermentable fiber, use a 1 to 10 scale each week to rate how well you’re tolerating it. If you’re not at a 7 or above, pause before advancing to the next phase.

• 1 = severe gas, bloating, or pain
• 5 = some symptoms, improving
• 10 = no symptoms, excellent digestion

If you want objective data, run these labs at baseline and again around week 8. These markers, while optional, offer biochemical confirmation that your butyrate–GLP-1 axis is restoring normal metabolic function.

• Fasting insulin — Falling levels suggest better GLP-1 signaling
• Triglycerides — Often improve as inflammation and insulin resistance drop
• Post-meal glucose — Ideally stays under 120 mg/dL at the 1-hour mark

Timeline: What to Expect as Your Gut Rebuilds

Your gut already knows how to help you lose weight — by producing butyrate, which fuels the cells that make GLP-1. This is how human metabolism was designed to function. Restore that system, and your cravings shrink, your blood sugar stabilizes, your inflammation calms down, and your body starts releasing excess weight naturally.

These shifts are clear signs that your body’s metabolic software is running the way it was meant to. Your gut doesn’t need to be perfect to start producing butyrate. But there’s a rhythm to recovery, and markers to know it’s working.

Phase
What Happens
Timeframe
Measurable Indicators

Terrain repair
Gas, bloating, and sensitivity begin to calm
1 to 3 weeks
Less urgency, firmer stools, more predictable digestion

Fiber reintroduction
Butyrate-producing strains begin to increase
2 to 4 weeks
Better tolerance of resistant starch, mood uplift

GLP-1 response
Appetite regulates, energy improves, cravings decrease
4 to 8 weeks
Fewer between-meal snacks, better AM energy

Metabolic reset
Satiety increases, fat loss begins, blood sugar stabilizes
6 to 12 weeks
Tighter waistline, reduced post-meal glucose swings

You can start putting these strategies into practice right now with my new book, “Weight Loss Cure; Melt Fat Naturally With Your Own GLP-1,” which provides a step-by-step plan to rebuild butyrate production, restore natural GLP-1 signaling, and correct the root drivers of weight gain. We’re also preparing a butyrate-support product designed to complement these foundational strategies. You can join the waitlist now, and when it becomes available, you’ll receive a $5 off coupon by email.

A New Series of Health Insights Is on the Way

WAŻNY

A New Series of Health Insights Is on the Way

Our team has been working behind the scenes to prepare new research and practical health
strategies for our readers. While we finish preparing what’s coming next, we invite you to
explore one of the most-read articles from our library below. See exactly what’s changing →

When it comes to vitamins, well-known examples that immediately come to mind include vitamins C and D. While these are certainly important, I believe that other vitamins also deserve their own spotlight, such as vitamin K2.

In this episode of the Wellness by Designs podcast, nutritionist Brad McEwen, Ph.D., explains the role of vitamin K2 in your body, and what happens when you don’t get enough of this nutrient.

How Vascular Calcification Occurs When You’re Deficient in Vitamin K2

One of the most significant benefits of vitamin K2 is its ability to support cardiovascular health. When calcium builds up in your arteries, it leads to stiffening and blockages.

• The importance of vitamin K2 for optimal cardiovascular health — Research shows that it activates biological processes that direct calcium away from your arteries and into your bones and other essential organs, but a deficiency can increase your risk of cardiovascular disease.

McEwen explains further,1 “One of the areas we’ve been looking at is a deficiency of vitamin K2 has been linked to vascular calcification. Not just coronary, but just overall calcification. And if you think of it this way, you got different mineral deposition, particularly calcium, of course, coming from the calcium hydroxyapatite — and we always say from the bones because that’s the main storage site into the vascular system and then going into the vascular wall because it gets trapped.”

• Blockage occurs due to the molecular weight of calcium — McEwen theorizes that the heaviness of calcium contributes to its propensity to cause arterial blockages.

“So, it’s like a big centrifugal force going through the arteries and then it just gets trapped because it’s, I don’t know, heavier? It’s like a big metal going through and then it embeds and over time, as you know, we talk about foam cells, atherosclerosis, etc., and it starts that calcium, you know, process,” he says.

From there, McEwen describes where the calcium actually embeds in your cardiovascular system, increasing your risk for clots that eventually block blood flow:2

“The biochemistry all combines together leading to this complex which, then, sat in the arteries and it can sit in the basement membrane of the artery. It can be on the inner or outer side of that membrane, leading to an inflammatory process and oxidative process, leading to like a firestorm in there.

The body tries to heal it, you know, by laying down fibrin and different connective tissue to protect it — putting a Band-Aid down, I suppose. And then that’s when you get your atherosclerosis, your plaque formation and then your eventual clot in that area.”

Heavy Metals Increase the Risk of Vascular Calcification Further

It’s not just a lack of vitamin K2 that increases your risk for vascular calcification. Even the very environment you live in influences your risk. McEwen recounts a case study related to this observation, wherein he saw a patient whose previous physicians couldn’t figure out what was happening with her despite trying out “every test under the sun.”3

• Heavy metals embed into your tissues — McEwen discovered that it was due to the presence of heavy metals in her childhood neighborhood, which embedded into her tissues. When she moved out of the area, the heavy metals circulated throughout her system, causing bone pain and increasing cardiovascular risk.

• Nutritional deficiencies contribute to vascular calcification via heavy metal exposure — According to McEwen, bone-related nutrient deficiencies do not direct calcium to where it’s needed the most.

“What I found out was due to her childhood, there was different heavy metals in the area, and that’s what deposited into the tissue. And when she moved around, that tissue left — because she didn’t have enough vitamin D, vitamin K, etc. — and then left the bone, so she had bone pain, and then embedded into her vascular system leading to cardiovascular link,” he says.4

Research Surrounding the Benefits of Vitamin K2

The benefits of vitamin K2 regarding cardiovascular health have been well-studied for many years now.

• Vitamin K2 makes your arteries more elastic — McEwen cited a study that involved 244 healthy postmenopausal women. Split into two groups, the test group (120 participants) took 180 micrograms of vitamin K2, and the control group (124 participants) took a placebo for a total of three years. After the study was completed, McEwen noted that the test group had improved arterial flexibility.5

• Increased vitamin K2 consumption helps improve other metabolic health markers — In another study, researchers followed 36,629 participants for 12 years and monitored their vitamin K2 intake. They found that those with a higher intake of vitamin K2 had a 29% lower risk of developing peripheral artery disease. Other improvements were noticed as well, including a 44% reduction in Type 2 diabetes risk, and a 41% reduction in high blood pressure.6

• The benefits of vitamin K2 on mitochondrial function — A study published in Open Heart journal showed that people with higher levels of K2 in their diet tend to have lower levels of arterial calcification and a reduced risk of heart disease.

Higher K2 levels also had a positive impact on mitochondrial health, particularly for cardiac muscles. “The role of vitamin K2 in mitochondrial function is mediated by its production of mitochondrial ATP, which has direct implications for contractile muscles (i.e., cardiac) that are comprised of abundant mitochondria.

Intake of vitamin K2 has been associated with increased cardiac output, stroke volume and heart rate and decreased blood lactate. These effects are consistent with the greater maximal cardiovascular performance seen with oral vitamin K2 supplementation, according to the researchers.”7

How Vitamin K2 Helps Strengthen Your Bones

Vitamin K2 is also essential for maintaining strong and healthy bones. Your bones are constantly breaking down and rebuilding, a process that relies on proper calcium distribution.

• Vitamin K2 activates bone-forming proteins — Research shows vitamin K2 helps promote osteocalcin, which is a protein that binds calcium to your bone matrix. Without enough vitamin K2, your bones will not be as strong as they should be, increasing your risk of fractures and osteoporosis.8

• Osteocalcin serves as the calcium guide — McEwen notes that osteocalcin, a vitamin K-dependent protein, helps promote stronger bones by transporting calcium to where it actually needs to go — your skeleton. Your body needs a constant influx of this all the time because it is always building itself up and removing old, damaged bone cells.9

The Sweet Spot Dosage of Vitamin K2

If you’re considering adding vitamin K2 to your diet, it’s important to get the right amount.

• Vitamin K2 requirements vary for different age groups — According to McEwen, much of the research he has studied had dosages between 90 and 180 micrograms per day, which he believes is the optimal for most adults.10 Youngsters and teenagers (10 to 18 years old) need around 90 micrograms, while children below the age of 10 need 45 micrograms.11

While some studies have explored higher doses, the standard recommendation is based on what has been shown to be effective without unnecessary excess.

• Find the ideal range based on your health needs — While McEwen recommends different ranges, he clarifies further by saying that the dosage will vary from person to person.

McEwen also mentioned another important precaution — taking excessively high doses of vitamin K2 won’t be good for your health because your body won’t be able to use it all:12

“One thing I always want to say when we do podcasts, and everything is it’s always the person in front of you. ‘What is the best dose for that person?’ And if they need 500 IUs of vitamin D and 90 micrograms of vitamin K2 from your determination, that’s the dosage that they need.

If they need a higher dose of, you know, 1,000 IUs of vitamin D3 and 180 micrograms of K2, that’s the dose regimen … [G]oing hard and fast is not always the best way to do it because, to me, it’s trying to push too much through all the time.

We get excited, some studies are very, very high dose and they seem to have the negative impact because, I believe, the regulatory pathways are not able to function effectively to make sure we get the best out of what it is.”

From McEwen’s statement above, you’re thinking, “What does vitamin D have to do with this entire process?” Well, vitamin D has been shown to play a role in calcium absorption. If you’re deficient in this important nutrient, your risk for rickets, a disease marked by skeletal deformities, increases.13 With enough vitamin D and vitamin K2, the calcium you get from your diet will go to the right organs.

Strategies to Ensure Your Body Gets Enough Vitamin K2

Based on McEwen’s findings, it’s clear that vitamin K2 has an important role in your body as it influences a wide range of functions, such as cardiovascular and skeletal health. The good news is that boosting your vitamin K2 levels is inexpensive and practical to implement. Here are my recommendations:

1. Add more K2-rich foods into your diet — The best way to get more vitamin K2 is through your diet, and they’re found in many foods. Nutritious choices include fermented foods like natto, aged cheeses (especially gouda and brie), egg yolks, and grass fed dairy products. Beef ideally organic and grass fed, also contains vitamin K2.14

2. Support your gut health for better vitamin K2 production — Your gut bacteria actually produce some of the vitamin K2 your body uses, but they need the right environment to thrive. If your digestion isn’t working well, or if you’ve been on antibiotics recently, you might not be making enough K2 on your own.

To support your gut, eat more fermented foods like sauerkraut, kimchi, and kefir, which provide the right bacteria to help your gut naturally produce K2. Also, make sure you’re eating plenty of fiber from vegetables and whole fruits to nourish the gut bacteria already active in your gut.

3. Pair K2 with vitamin D — As noted by McEwen, vitamin K2 and vitamin D work together to control the flow of calcium in your body — vitamin D helps boost absorption, while K2 makes sure it goes to the right places.

If you’re taking a vitamin D supplement but not getting enough K2, you’re increasing your calcium levels without giving your body the ability to direct it properly. If you’re already supplementing with D3, make sure you’re also getting enough K2, either through food or supplements to maintain proper homeostasis.

4. Stay active to keep your bones strong — Movement is key for keeping your bones in good shape. Weight-bearing exercises like walking, strength training, and bodyweight exercises help signal your body to send calcium into your bones where it belongs.

As noted by McEwen, sitting for long periods without movement also changes your bone mineral density, and all the vitamins K2 and D you’ve been taking will be for nothing.15 If you spend a lot of time sitting, I encourage you to go for a walk outside to boost your fitness levels.

5. Take a high-quality vitamin K2 supplement if needed — If you’re not getting enough K2 from your food, adding a supplement is a viable way to ensure you’re covered. Look for a supplement that contains MK7, as this form stays in your body longer and is more effective than other types. For best results, take it with a meal that contains healthy fat, as K2 is a fat-soluble vitamin.

FAQ — Common Questions About Vitamin K2

Q: What is vitamin K2 and why is it important?

A: Vitamin K2 plays a crucial role in calcium metabolism. It helps prevent vascular calcification by directing calcium away from arteries and into bones, reducing the risk of heart disease and arterial stiffness. Additionally, it supports bone health by strengthening bone density and reducing the risk of fractures and osteoporosis.

Q: How does vitamin K2 benefit cardiovascular health?

A: Vitamin K2 activates proteins that prevent calcium buildup in the arteries, reducing the risk of vascular calcification, atherosclerosis, and blood clots. Research shows that people with higher vitamin K2 intake have a 29% lower risk of peripheral artery disease, a 44% reduction in Type 2 diabetes risk, and a 41% reduction in hypertension.16

Q: What are the best dietary sources of vitamin K2?

A: Good sources of vitamin K2 include fermented foods (like natto and aged cheeses), pastured egg yolks, grass fed dairy products, and organic, grass fed beef. Your very own gut bacteria also produce some vitamin K2, which is further supported by consuming probiotics and fiber-rich foods.

Q: What is the recommended daily intake of vitamin K2?

A: The general range for adults is 90 to 180 micrograms per day, while the range for children 10 to 18 years old is 90 micrograms per day. For children up to 10 years old, the dosage is 45 micrograms per day.

Q: How can I ensure optimal vitamin K2 levels?

A: To maintain adequate vitamin K2 levels, support your gut health with fermented foods and fiber and pair it with vitamin D for better calcium absorption. Take a high-quality supplement if dietary intake is insufficient.

Obesity continues to be a problem in America. According to the U.S. Centers for Disease Control and Prevention (CDC), 73.6% of adults 20 years and older are overweight and obese.1 This staggering number is putting serious strain on the economy, leading to a whopping $1.4 trillion in annual health expenses.2 Having excess body fat causes an assortment of health complications to arise, including high blood pressure, heart disease, stroke, metabolic syndrome, fatty liver disease, and Type 2 diabetes.3

While these complications have been extensively studied within the context of obesity, they are metabolic in nature. Another part that’s rarely discussed is the impact of obesity on infectious disease — complications caused by microbes. Now, a study published in The Lancet attempts to answer this mystery.

Obesity Drives a Measurable Rise in Severe Infection Risk

The researchers explored how obesity affects your risk of mortality. The rationale for following this line of research was because the metabolic effects of obesity have already been extensively covered, but much less is known about its impact across different types of infectious diseases.4

For the analysis, the researchers selected 67,766 adults from two Finnish cohort studies and 479,498 adults from the United Kingdom (U.K.) Biobank. The participants’ body mass index (BMI) was tracked at baseline — 1998 to 2002 for the Finnish population and 2006 to 2010 for the U.K. population. Infection-related mortality risk due to obesity was analyzed until 2018, 2021, and 2023 — before, during, and after the COVID-19 pandemic.

• Mortality risk steadily climbed as BMI increased — People in the highest obesity class had a 2.75 times higher risk for severe nonfatal infections in the Finnish cohorts and 3.07 in the U.K. Biobank, meaning triple the risk compared to adults at a healthy weight.

For fatal infections, the danger was even higher. The risk reached 3.06 times in Finland and 3.54 times in the U.K., underscoring the magnitude of this problem.

• About 1 in 10 deaths from infectious disease are caused by obesity — After modeling the global impact, the researchers reported that 8.6% of all infection-related deaths in 2018 were attributable to obesity, rising to 15.0% during 2021 and settling at 10.8% (0.6 million out of 5.4 million) in 2023 as global conditions shifted due to the COVID-19 pandemic.

Another striking detail lies in how consistent the findings were across measurement methods. When the researchers evaluated obesity using waist circumference, waist-to-hip ratio, and body fat percentage, the risk remained almost identical — 1.7 times for severe infection across metrics. In short, excess fat, no matter how it’s measured, puts your health at risk.

• Infection severity was closely linked to obesity — The analyses included long follow-up periods, and captured infection events before, during, and after the COVID pandemic. Across all eras, the pattern held. Even when the COVID-19 pandemic entered the picture, the underlying risk landscape hardly budged.

Some groups experienced even steeper risk elevations than others. While the study reports strong effects across nearly everyone with obesity, individuals with class III obesity faced the largest surge in both hospitalizations and deaths.

• For context, obesity is currently broken down into three classes — Class I is a BMI of 30 to 34.9, and class II is a BMI of 35.0 to 39.9. Lastly, class III refers to a BMI of 40 or higher.5 Moving from overweight (BMI between 25 and 29.9) to class I obesity created a measurable rise in risk. However, advancing to class II and class III amplified the danger sharply.

• Excess fat tissue upsets metabolic health by keeping your body in a constant low-grade inflammatory state — As a result, immune function is also affected. According to the researchers, these include “[r]educed T-cell and NK-cell function, neutrophil dysfunction, dysregulated complement and adiponectin signalling, and diminished mucus clearance and lymphatic flow.”

A Deeper Look at How Obesity Affects Your Risk for Infectious Disease

In the previous study, researchers analyzed the risk that obesity poses to your health when it comes to infectious disease. Now, it’s time to look at the biological mechanisms involved. In another study published in the International Journal of Obesity, researchers outlined different ways excess body fat reshapes your immune function and becomes vulnerable to infections.6

• Higher body fat percentage equals higher infectious disease risk — The study reported the same pattern seen in The Lancet study — infections did not just simply occur more often in individuals with obesity; they progressed more aggressively.

According to the authors, “obesity has substantial effects on the immune system,” meaning the body’s internal security system struggles to respond effectively once pathogens enter when excess body fat gets in the way. The image below provides a summary of their theories:

Source: International Journal of Obesity volume 46, pages 449 to 465 (2022)

• Excess adipose tissues (body fat) behave like an active endocrine organ — They release inflammatory hormones and chemical signals that disrupt communication between immune cells. In plain terms, the immune system loses coordination. When you live with this imbalance, you face a slower response to viruses and bacteria, which allows these microbes to multiply more easily.

• Obesity alters the architecture and function of the respiratory system — The authors explained that excess fat around the chest wall reduces lung expansion and lowers lung volumes, creating a mechanical disadvantage when the body tries to clear mucus or maintain airflow during an infection.

If you’ve ever felt out of breath walking up a short flight of stairs, this is the same limitation playing out at a microscopic level during a bout of respiratory illness. Bacteria and viruses take advantage of that reduced airflow, settling deeper into lung tissues.

• Inflammation persists for years in many obese individuals — Over time, this constant inflammatory pressure exhausts their immune cells. The review highlights that macrophages — the immune cells responsible for engulfing and clearing pathogens — switch into a less effective mode of activity under the influence of obesity-related inflammation. Instead of clearing invaders quickly, macrophages operate sluggishly, which prolongs infections and increases tissue damage.

• Respiratory infections often worsen the fastest, but skin issues aren’t far behind — Altered circulation reduces the body’s ability to deliver immune cells to the site of injury. However, changes in the skin also slow down wound-healing, allowing bacteria to enter your system faster.

• Excess skin due to obesity increases risk for topical infections — As body fat begins to increase, the skin compensates accordingly and causes more skin folds. The researchers noted that these are factors that increase the risk of fungal and bacterial skin infections.

• Obese individuals usually have existing nutrient deficiencies, which worsen the problem further — For example, vitamin D deficiency is far more common in adults with obesity. This nutrient plays an important role in immune function, especially in controlling inflammation in the respiratory tract.

• Adipose tissue in obesity recruits immune cells into fat stores, diverting them from circulation — This means that your body’s main protectors are pulled away from where infections unfold. As a result, when a pathogen enters through the lungs, skin, or gut, fewer active immune cells are available to meet the threat. Your body ends up fighting with a depleted army:7

“In obesity, visceral adipose tissue produces an excess of cytokines such as tumour necrosis factor α (TNFα) and interleukin (IL)-6 and 1β that could weaken the response of immune cells during an infectious stimulus,” the researchers explained.

“In addition, in a state of excess weight, a condition of hyperleptinemia is observed that can contribute to immune imbalance.”

How to Restore Your Healthy Metabolism and Stop Fat Storage

As noted in the findings, excess body fat won’t do your health any good, and the best time to start getting rid of it is today. If you’ve been having difficulty losing weight despite your best efforts — be it exercising or modifying your diet — the problem is in your cellular energy function.

When your cells are saturated with polyunsaturated fats (PUFs) like linoleic acid (LA), your body lowers its metabolic rate, shifting into storing fat instead of burning it. Thus, the foundational step isn’t running countless miles because you can’t outrun a bad diet. The answer lies in fixing how your body burns fuel through corrective action by way of eating properly.

1. Remove vegetable oils from your diet — Every time you eat ultraprocessed foods or food cooked in soybean, canola, corn, safflower, or sunflower oil, you push more LA into your tissues, slowing down your cellular energy production and nudging your body toward metabolic hibernation.

Once you reduce and eliminate these unhealthy oils from your diet, your cells stop fighting the inflammatory load and start burning fuel with far less strain. As this shift settles in, you feel more stable because your mitochondria burn energy cleanly.

I recommend keeping your LA intake under 3 grams a day. This amount aligns with the intake that our ancestors had before the rise of industrially made vegetable oils. To help you with accurate monitoring, sign up for the Mercola Health Coach app once it becomes available. It will contain a feature called a Seed Oil Sleuth, which will compile your daily LA intake to a tenth of a gram.

2. Choose stable fats to keep energy steady — Continuing the point above, when you trade out seed oils for healthier saturated fats like grass fed butter, coconut oil, ghee, and beef tallow, you give your metabolism a major advantage. These fats burn cleanly, support oxygen use, and help your cells stay switched on instead of drifting into storage mode. It’s the difference between running your engine on premium fuel versus watered-down gasoline.

3. Choose healthy carbs to maintain metabolic flexibility — Don’t be tempted to cut out carbs in an effort to lose weight because this forces your body into a low-oxygen, low-energy environment. When chosen carefully, carbs, especially healthy ones, protect your metabolism. That means choosing whole fruits, white rice, and root vegetables — foods that help promote proper cellular energy. Don’t choose refined and ultraprocessed carb sources.

4. Dial down stress — Feeling tense, overstimulated, or wired, especially at night, usually means that your cortisol and estrogen are running too high, pushing your system toward fat storage and suppress healthy energy production.

To lower your stress levels, remember to get daily sunlight and restful sleep, and minimize back on alcohol (or remove it entirely). As those stress signals drop, your metabolism burns energy better instead of hoarding it.

5. Teach your body to switch metabolic fuels through exercise — Staying inactive teaches your mitochondria to conserve rather than produce. Doing gentle strength training, daily walking, and light resistance exercise can wake them back up.

Movement tells your cells how to use both fat and carbs for energy, instead of locking into one inefficient mode. You don’t need extreme exercise — you only need consistent motion that challenges your muscles and keeps energy flowing.

Frequently Asked Questions About Obesity-Related Infectious Disease Mortality

Q: How does obesity increase the risk of infectious disease?
A: Obesity creates chronic inflammation that impairs T-cells, NK-cells, and macrophages. Excess fat diverts immune cells into fat stores, while insulin resistance raises blood sugar, helping microbes spread.

Q: How much does obesity raise the risk of severe or fatal infections?
A: Research shows that people in the highest obesity class face up to 3.54 times the risk of fatal infections. Globally, about 1 in 10 infectious disease deaths are attributable to obesity.

Q: Why are respiratory infections especially dangerous for people with obesity?
A: Excess chest fat restricts lung expansion and airflow, making it harder to clear mucus. This allows bacteria and viruses to settle deeper into lung tissue and progress more aggressively.

Q: Does the type of obesity measurement matter when assessing infection risk?
A: No. Whether using BMI, waist circumference, waist-to-hip ratio, or body fat percentage, infection risk remained nearly identical — about 1.7 times higher across all metrics.

Q: What steps can reduce infection risk related to obesity?
A: Eliminating vegetable oils high in linoleic acid (LA), choosing stable fats and healthy carbohydrates, managing stress, and incorporating consistent gentle exercise to restore metabolic function all work together to help reduce excess body fat and protect your health.