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A New Series of Health Insights Is on the Way

VIKTIG

A New Series of Health Insights Is on the Way
Our team has been working behind the scenes to prepare new research and practical health strategies for our readers. While we finish preparing what’s coming next, we invite you to explore one of the most-read articles from our library below. See exactly what’s changing →

In a world built around desks, cars, and screens, it’s easy to spend hours without moving. But this daily routine — something as ordinary as staying seated too long — quietly sets the stage for serious cardiovascular problems. In fact, too much sitting has become a significant threat to heart health.

If you’re like most people, you might think regular workouts are enough to stay in good shape. You could even believe that hitting the gym or getting your steps in at the end of the day offsets everything else. But even regular exercise isn’t enough to overcome the damage caused by too much time spent sitting still.

What you do throughout the day, including how often you shift, stand, and break up your sedentary time, matters. Even if you consider yourself active, the hours spent sitting at your desk, in your car or on your couch could still be damaging your heart in ways you don’t feel yet. In addition to cutting down on the time you spend sitting, regular movement throughout the day — not just scheduled workouts — is essential for protecting your cardiovascular health.

Too Much Sitting Raises Your Heart Risks Even if You Exercise

In a study published in the Journal of the American College of Cardiology, researchers analyzed data from 89,530 middle-aged and older adults in the UK Biobank cohort.1

The goal was to measure how sedentary behavior, meaning hours spent sitting or lying down during waking hours, impacted the risk of developing cardiovascular conditions like heart failure, irregular heartbeat, heart attacks, and death from heart-related causes. What set this study apart was its use of objective data from wrist-based activity trackers rather than self-reporting, which is often inaccurate.

• The population was mostly healthy, but age and gender varied — Participants were, on average, 62 years old, and 56% were women. All wore the wrist-based activity tracker continuously for one week to get precise daily movement data.
After that, they were followed for about eight years to track the development of heart-related events.2 The study excluded those with missing data or extreme sedentary hours (more than 18 hours per day), ensuring the focus remained on realistic activity patterns.

• Sitting over 10.6 hours a day raised heart failure risk by 45% — When researchers compared different levels of sedentary time, they found a clear tipping point. People sitting more than 10.6 hours a day had a 45% higher risk of heart failure and a 62% higher risk of dying from cardiovascular causes compared to those sitting less than 9.4 hours.

• Even active people weren’t protected from the risks of too much sitting — Those who exercised for 150 minutes per week of moderate to vigorous activity were still at increased risk if they sat for long periods. In other words, going to the gym in the morning doesn’t undo the damage of sitting all day. This is key if you think of movement as a one-time task rather than a rhythm throughout your day.

• Just 30 minutes less sitting a day made a measurable difference — Reallocating only 30 minutes of daily sitting time to light or moderate activity lowered the risk of heart failure by 7%. Even in participants who already met the minimum activity guidelines, this shift still led to benefits. It suggests that breaking up sitting time with short walks or standing breaks throughout your day has real, immediate health payoffs.

Why Sitting Too Long Damages Your Heart and Metabolism

While irregular heartbeat and heart attacks showed smaller increases in risk (11% and 15%, respectively) with prolonged sitting, the relationship was linear. This means the more sedentary time recorded, the higher the risk across the board. For heart failure and cardiovascular death, however, the risk jumped dramatically once you crossed the 10.6-hour threshold. This inflection point marks a key behavioral target for preventing future disease.

• This damage happens because of the way prolonged sitting affects blood circulation — Sitting too long causes blood flow to slow down, especially in your legs. This impairs endothelial function — the ability of blood vessels to dilate and constrict properly.

Over time, that increases blood pressure and stiffens arteries, creating more work for your heart. Sluggish blood flow also increases the risk of clot formation, inflammation, and poor oxygen delivery to tissues.

• Physical inactivity also triggers changes in key metabolic hormones — The longer you sit, the less muscle activity you have. That lack of contraction lowers your body’s sensitivity to insulin, promoting blood sugar instability and fat accumulation, particularly around the organs.

This can lead to metabolic syndrome, a cluster of conditions including high blood pressure, high blood sugar, and abnormal cholesterol levels, all of which are closely tied to cardiovascular disease.

• Mitochondrial activity slows during sedentary time, lowering energy production — When muscles aren’t being used, their mitochondria — the energy factories of the cell — go into a low-power state. This reduces fat burning and oxygen use, leading to oxidative stress and chronic inflammation over time.

These processes are central to the development of heart failure and other cardiovascular conditions. Simply standing up activates more muscle fibers and reengages your metabolism in ways that sitting does not.

Break the Heart-Harming Habit of Sitting Too Long

If you’re like most people, you’re sitting too much without realizing just how much it’s costing you. It doesn’t matter if you hit the gym a few times a week. If you’re spending 10 or more hours a day sitting, you’re stacking the odds against your heart. Your risk of heart failure, irregular heartbeat and cardiovascular death all rise when you’re glued to a chair.

That’s the hard truth from the data. But here’s the good news: you don’t need a gym membership or a drastic lifestyle overhaul to reverse it. You just need to be strategic and consistent with movement throughout your day. Here are five simple but powerful steps to reduce your sitting-related cardiovascular risks:

1. Avoid long periods of sitting — This is the most important step. If you track one thing from now on, let it be your total sedentary time. The danger zone in the study started at 10.6 hours, but for optimal health limit sitting to three hours a day or less.

If you sit at a desk for work or school, start timing your sedentary blocks. Use an app, a fitness tracker or even a kitchen timer. Break up your day. If you’re stuck in meetings or at a computer, stand during calls, pace while thinking or switch positions regularly.

2. Stand for 10 minutes every hour — Even if you’re on a deadline or deep into a show, you’ve got to break the pattern. Standing up for just 10 minutes every hour activates muscles, restores circulation, and restarts your metabolism. This interrupts the biological damage caused by long sedentary stretches.

A standing desk is a smart investment if you work from home. If you’re in an office, create a habit of standing during routine tasks — like checking emails or reading.

3. Replace 30 minutes of sitting with walking each day — According to the research, just a half-hour swap from sitting to walking cut heart failure risk by 7% — and that was true even for people already meeting exercise guidelines. So, if you’re walking at lunch or pacing while on the phone, you’re already helping to protect your heart.
For extra impact, walk outside after meals. It helps digestion, balances blood sugar and counts as light-intensity movement that your heart will thank you for. Even when you’re in the office, a walking pad is a simple way to work in more movement.

4. Build movement into your daily routine — not just workouts — Structured workouts are great, but they don’t undo eight hours of sitting. Movement throughout the day is what matters most.

Turn meetings into walking meetings. Always take the stairs. Park farther away. If you’re a parent, play on the floor with your kids. If you’re older or have limited mobility, even gentle standing stretches or household tasks help keep your body out of the sedentary danger zone. Don’t underestimate small movements — they add up fast.

5. Challenge yourself to walk more than you think you need — Try to challenge yourself to walk as much as possible, even if it’s just around your home or yard. Use a step tracker to gamify it, set a daily goal, then beat it. When you turn movement into a challenge, you boost motivation and make the process enjoyable. This helps break the habit of being still.

Remember, you don’t need perfection. You just need momentum. The data shows that even modest, consistent shifts away from sitting will start to rebuild your metabolic resilience and protect your heart for the long run.

FAQs About Excessive Sitting and Heart Health

Q: How many hours of sitting is considered dangerous for heart health?
A: The study found sitting for more than 10.6 hours per day significantly increases your risk of heart failure and cardiovascular death. This is the threshold where the risk begins to spike, even if you’re physically active the rest of the day. However, for optimal health strive to limit sitting to three hours a day or less.

Q: Does exercising cancel out the risks of sitting too long?
A: No. Even if you exercise regularly, excessive sitting still raises your risk of heart disease. The damage caused by prolonged sitting accumulates throughout the day and isn’t reversed by a single workout.

Q: What heart problems are linked to too much sitting?
A: The study found higher rates of heart failure, irregular heartbeat, heart attacks and cardiovascular death in people who spent too much time sitting. Heart failure risk rose by 45% and cardiovascular death risk jumped by 62%.

Q: What’s the easiest way to reduce heart risks from sitting?
A: Start by standing for at least 10 minutes every hour. Also replace 30 minutes of sitting time with walking each day. These small changes dramatically lower your cardiovascular risk, even if you’re already active.

Q: Do I need a gym or special equipment to protect my heart?
A: Not at all. Simple changes like walking during phone calls, using a standing desk or taking the stairs make a difference in protecting your heart. The key is to move regularly throughout the day, not just during workouts.

For years, vaping was marketed as the cleaner alternative, a way to keep the ritual of smoking without the tar, the smell, or the serious health consequences. That framing is collapsing. A growing body of research now points in the opposite direction, and the latest analysis lands with unusual force: scientists are no longer hedging about whether e-cigarettes cause cancer. They’re explaining how.

What makes this finding so difficult to dismiss is that the evidence converges from multiple independent directions. Evidence from human biomarkers, laboratory experiments, and animal research is pointing to the same conclusion from different angles.

The signals follow the same pattern that played out with cigarettes in the mid-20th century, when independent lines of evidence pointed toward cancer for years before the medical establishment, and the tobacco industry, were willing to act on them. If you picked up vaping believing it was a safer landing pad, consider this: researchers found measurable DNA damage in the mouth and lung tissue of vapers who had never smoked a single cigarette.

The damage was already underway. It begins at the cellular level, quietly, long before a cough or a tight chest ever shows up. The real question is no longer whether vaping carries cancer risk; it’s how the exposure drives those changes inside your body, and what you can do to stop them.

Multiple Lines of Evidence Link Vaping Directly to Cancer Development

A large-scale scientific review published in Carcinogenesis examined a wide body of research to determine whether e-cigarettes cause cancer on their own, independent of conventional smoking.1 This type of qualitative risk assessment pulls together different kinds of data to reach a conclusion faster, especially when public health is at stake. The goal was to determine whether the biological damage from vaping follows the same patterns already known to lead to cancer.

• Real-world users show clear signs of cellular damage — The researchers focused heavily on biomarkers, which are measurable signs inside your body that show harm is happening at a microscopic level. In people who vape, these markers revealed DNA damage, oxidative stress, and inflammation in tissues like the mouth and lungs.
DNA damage means your cells lose the ability to copy themselves correctly. Oxidative stress occurs when unstable molecules called free radicals overwhelm your body’s built-in antioxidant defenses.
Your cells have a limited capacity to neutralize these molecules, and every puff of vapor pushes you closer to that limit. Inflammation means your immune system stays activated, which creates an environment where abnormal cells grow instead of being removed. These changes lined up directly with the early stages of tumor development.
• Vape aerosol contains a mix of known carcinogens — The study identified several harmful substances in e-cigarette vapor that explain why this damage occurs. These include nicotine-derived nitrosamines, which are among the most well-established cancer-causing chemicals in tobacco research.
Volatile organic compounds — reactive gases like formaldehyde and acrolein that are released when e-liquid is heated — also showed up, along with flavoring agents that break down into toxic byproducts.
Even the device itself contributes risk. Heating coils release trace metals into the aerosol, adding another layer of exposure. You’re not inhaling harmless water vapor. You’re inhaling a complex chemical mixture that directly interferes with normal cell function.
• Animal experiments confirm tumor formation — To move beyond correlation, researchers examined rodent studies where exposure could be tightly controlled. In these experiments, mice inhaled e-cigarette aerosol over time.
The result was the development of lung adenocarcinomas, a type of cancer that forms in glandular tissue in the lungs. This shows a cause-and-effect relationship. When exposure increases, tumors appear. That pattern strengthens the argument that vaping doesn’t just coincide with cancer risk; it drives it.
• The risk increases when vaping combines with smoking — Another critical finding involves people who both vape and smoke conventional cigarettes. This pattern, often called dual use, creates a compounding effect rather than reducing harm.
Epidemiological data show that individuals in this category face up to a fourfold higher risk of lung cancer compared to those who avoid both habits. That means switching to vaping without fully quitting smoking doesn’t reduce danger. It multiplies it. Many users get stuck in this cycle, unable to eliminate either habit.

How Vaping Drives Cancer Step by Step

The previous section showed what researchers found — damage markers in human tissue, carcinogens in the aerosol, tumors in animals, and compounding risk in dual users. Now let’s walk through how that damage unfolds inside your body, step by step, from the first puff to tumor formation.
Earlier research on e-cigarettes often called for more data before drawing conclusions. That has changed. Between 2017 and 2025, the tone of scientific reviews moved steadily toward warning about carcinogenicity.
According to study co-author Freddy Sitas, associate professor at the University of New South Wales in Australia, “The evidence was remarkably consistent across fields,” leading to what they describe as an “unequivocal finding” of increased cancer risk.2 In plain terms, the scientific community no longer treats this as an open question. The pattern of harm is established.

• Cancer development follows a step-by-step biological process — The mechanisms described in the paper explain how vaping pushes your body toward disease. It starts with genotoxic effects, meaning direct damage to your DNA. Once your genetic material is altered, cells begin to behave abnormally. They divide when they should not. They fail to repair themselves. Over time, these errors accumulate and form the foundation for tumors.
• Oxidative stress accelerates the damage inside your cells — The study highlights oxidative stress as a central driver of harm. When your body produces too many reactive molecules and can’t neutralize them, they attack proteins, lipids, and DNA. Think of it as internal rust forming inside your cells. This damage weakens your natural defenses and speeds up the transition from normal tissue to diseased tissue.
• Chronic inflammation creates the perfect environment for cancer growth — The final piece involves inflammation that doesn’t shut off. Instead of shutting down after the threat passes, your immune system stays locked in an activated state, releasing chemical signals that inadvertently protect damaged cells and encourage them to keep dividing.
Over time, that allows mutated cells to expand and form tumors. When you connect these steps — DNA damage, oxidative stress, and inflammation — you see a clear pathway from vaping exposure to cancer development.
It’s also worth noting that the carcinogens in e-cigarette aerosol don’t stay confined to the user’s lungs. Secondhand vapor contains measurable levels of nicotine, particulate matter, and volatile organic compounds, meaning bystanders — including children and nonsmoking partners — are exposed to the same class of chemicals, albeit at lower concentrations.

Cut Your Cancer Risk from Vaping at the Source

Once you understand that vaping drives cancer through three interconnected mechanisms — DNA damage, oxidative stress, and chronic inflammation — the strategy for reducing your risk becomes straightforward. You need to eliminate the source of exposure, then support each of those three defense systems directly. Every recommendation that follows targets one or more of these specific pathways.

1. Remove the exposure completely, not halfway — If you’re still vaping, the first step is simple and direct: stop the exposure that’s driving the damage. Cutting back doesn’t solve the problem because even low levels of repeated exposure continue to trigger DNA damage, oxidative stress, and inflammation. If you’re both smoking and vaping, you’re stacking risks on top of each other. You need to break that cycle fully. That is the single most important move you can make.
That said, quitting nicotine cold turkey isn’t realistic for everyone. If you need support, evidence-based options include behavioral counseling, electrical brain stimulation with exercise, and structured vaping and smoking cessation programs. The key point is committing to a quit date and a plan, not just an intention.
2. Avoid the dual-use trap that multiplies your risk — If you switched to vaping thinking it would replace smoking, but you still do both, you are in the highest-risk category described in the research. That pattern drives a fourfold increase in lung cancer risk. If this applies to you, your priority is not “reducing” cigarettes. Your priority is eliminating both sources. Partial substitution keeps the biological damage active.
3. Support your body’s repair systems with real fuel — It’s easier to quit vaping and smoking if you’re healthy. Your cells repair DNA and control inflammation using energy. If your metabolism is weak, your ability to recover from damage drops. You need adequate carbohydrates — around 250 grams daily for most adults — to support mitochondrial function, which is your cell’s energy system.
You also need enough protein, roughly 0.8 grams per pound of lean body mass per day, or 1.76 grams per kilogram, with one-third coming from collagen to support tissue repair. This directly affects how well your body handles cellular injury.
4. Lower oxidative stress by removing modern triggers — Vaping adds to a broader problem: oxidative stress from modern exposures. You want to reduce the total burden. That means eliminating ultraprocessed foods and seed oils, such as soybean, corn, canola, and sunflower oil, which are high in linoleic acid. Replace them with stable fats like grass fed butter, ghee, and tallow.
These changes reduce the background stress on your cells so they’re not constantly under attack from multiple directions at once.
5. Use movement to break the addiction cycle and restore control — If you’re trying to quit, structured movement is a powerful tool. Regular exercise reduces cravings, stabilizes your mood, and gives your brain a replacement reward signal that doesn’t rely on nicotine. Even 10 to 15 minutes of brisk walking or a few sets of bodyweight exercises, like pushups, squats, or climbing a flight of stairs, helps disrupt cravings in real time.
Aim for at least 20 to 30 minutes of moderate movement daily, working your way up to one hour of walking daily. Increase movement gradually as your lung capacity recovers. The goal is to give your brain a reliable alternative to nicotine every time the urge hits.
Over time, this also builds confidence. Each time you ride out a craving without reaching for a vape, you’re rewriting the pattern. That accumulated evidence — proof that you can tolerate discomfort — is what makes long-term freedom from the habit possible.

FAQs About Vaping and Cancer

Q: What does the latest research say about vaping and cancer?
A: A major 2026 review found that e-cigarettes are “likely to cause lung cancer and oral cancer,” based on consistent evidence from human biomarkers, lab studies, and animal research.3 This marks a shift from earlier uncertainty to a clear scientific concern.

Q: How does vaping damage my body at the cellular level?
A: Vaping exposes your body to chemicals that cause DNA damage, oxidative stress, and chronic inflammation. These three processes work together to disrupt normal cell function, allowing damaged cells to grow uncontrollably and form tumors.

Q: What harmful substances are found in vape aerosol?
A: E-cigarette vapor contains nicotine-derived nitrosamines, volatile organic compounds, toxic flavoring byproducts, and metals from heating coils. These substances are known to interfere with cell health and are directly linked to cancer development.

Q: Is vaping safer than smoking cigarettes?
A: The evidence doesn’t support that assumption. While vaping was marketed as a safer alternative, research now shows it follows similar biological pathways that lead to cancer. Using both vaping and smoking together raises lung cancer risk even more.

Q: What is the most effective way to reduce your risk?
A: The most important step is to eliminate exposure completely. Continuing to vape, even at lower levels, maintains the cycle of cellular damage. Supporting your body with proper nutrition, reducing oxidative stress, and using exercise to break nicotine dependence strengthens your ability to recover and stay free of the habit.

Test Your Knowledge with Today’s Quiz!
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Which protein links gut health to Alzheimer’s disease progression?

Dopamine
Insulin
Serotonin
Amyloid-beta
Amyloid-beta builds up in the gut, disrupts nerve signaling, and can spread to the brain, contributing to cognitive decline. Learn more.

A New Series of Health Insights Is on the Way

VIKTIG

A New Series of Health Insights Is on the Way
Our team has been working behind the scenes to prepare new research and practical health strategies for our readers. While we finish preparing what’s coming next, we invite you to explore one of the most-read articles from our library below. See exactly what’s changing →

Pelvic discomfort, bladder leaks, and chronic constipation are signs your body is asking for help. Yet millions of women brush these symptoms aside, assuming they’re just part of aging or the aftermath of childbirth. That silence creates a major gap in care, leaving many to suffer needlessly for years without realizing there’s a name for what they’re experiencing — and more importantly, that there are effective solutions.

The truth is, pelvic floor dysfunction affects far more women than most realize, but it’s rarely discussed openly. Whether you’re 25 or 75, these symptoms appear slowly or suddenly, triggered by physical strain, muscle imbalance, or changes in hormones and weight. And once they start interfering with your daily life, the impact is exhausting emotionally, socially, and physically.

You don’t have to accept it as your new normal. With the right strategies and support, you can retrain your body, restore function, and feel confident in your own skin again. To get there, you need to understand what’s really going on beneath the surface and how the latest research is finally shining a light on just how common and treatable these disorders truly are.

Pelvic Floor Disorders Are Far More Common Than Most Doctors Realize

A study published in Scientific Reports examined 25,425 adult women seen in family and internal medicine clinics to determine how many had pelvic floor disorders (PFDs), a group of conditions involving bladder leaks, bowel dysfunction, and organ prolapse.1 The average woman in the study was middle-aged, with a body mass index (BMI) of 29.4, which falls just under the obesity threshold.

The goal was to see how these issues correlate with age, weight, race, and number of childbirths. Rather than relying on questionnaires or specialist clinics, this study used real-world data from primary care visits to get a clearer picture of how common PFDs are in everyday life.

• One in three women had a pelvic floor disorder but most had no idea what was causing their symptoms — In this primary care sample, 32% of women had at least one PFD. Bowel dysfunction affected 24.6%, urinary incontinence 11.1%, and pelvic organ prolapse 4.4%. Even more revealing: 6.5% of women had more than one type of PFD, meaning these conditions often go hand in hand.

• Older age and higher BMI both dramatically raised the odds of having one or more pelvic disorders — The older you are, the higher your chances of a PFD. For every 10 years of age, your risk climbs by about 24%. Among women over 65, 29.6% had at least one disorder, compared to just 12.2% of those under 30. BMI also mattered: each one-point increase in BMI raised the odds of urinary issues by 3.8%. These statistics highlight that both age and weight are strong drivers of pelvic floor dysfunction.

• Women with difficult bowel movements were the largest and most overlooked group in the study — Bowel dysfunction, especially difficulty passing stool, was far more common than prolapse or urinary issues. In all, 15.8% had chronic straining or incomplete emptying, which raises the risk of hemorrhoids, pain, and long-term damage to the rectum. Doctors often ignore or miss these symptoms, especially if women don’t bring them up directly.

• Many women live with multiple pelvic disorders, yet never connect the dots or get referred for help — In the group studied, 1 in 15 had two or more types of pelvic issues, yet most weren’t seeing a specialist. Since family doctors don’t always ask about these symptoms, women go undiagnosed for years, especially when they assume things like leaking during exercise or straining to go to the bathroom are “just part of getting older.”

• Most cases of pelvic floor disorders are missed in general practice, even though the signs are easy to spot — The data shows that women most at risk — those who are older or have a higher BMI — are showing up in primary care with PFD symptoms but often leave without answers. That’s a missed opportunity. Screening tools and simple questions about bladder and bowel control could help identify these problems earlier, before they spiral into chronic pain or social withdrawal.

Most Pelvic Disorders Don’t Require Surgery, but You Do Need to Speak Up

According to UCLA Health, most women assume these symptoms are part of aging or something they’re supposed to tolerate. But that’s false. “PFDs are not a normal part of aging,” they state directly.2 Even though they become more common as women get older, that doesn’t mean they’re untreatable or something you have to live with forever.

• You have options; surgery is not your only path to healing — Women often fear that the only fix for pelvic issues is surgery. But UCLA Health outlines several non-surgical treatments that work, depending on your symptoms and preferences. These include pelvic floor physical therapy, medications, nerve stimulation (including tibial nerve therapy), and medical devices like pessaries that support your organs from within the vaginal canal.

• Strengthening your pelvic floor muscles could help prevent or reverse symptoms — Strengthening exercises like Kegels are one of the most effective tools to use on your own. These exercises target the muscles that control urination and bowel movements, and improve both control and comfort. UCLA Health encourages this kind of self-care, as these strategies often help delay or avoid more invasive treatments, especially when caught early.

• Lifestyle changes matter; your weight, diet, and bathroom habits all play a role — Simple adjustments in daily life dramatically lower your risk of developing or worsening pelvic disorders. If your gut is healthy, eat a high-fiber diet to avoid constipation, cut back on caffeine and alcohol to reduce bladder irritation, and maintain a healthy weight to reduce pressure on pelvic organs. Avoiding heavy lifting and managing how often you go to the bathroom also make a difference.

• Doctors don’t always bring this up, so you’ll need to advocate for yourself — Many women don’t get asked about their pelvic symptoms during routine checkups. And because PFDs aren’t life-threatening, they often get pushed aside. But ignoring them only leads to more disruption down the road. UCLA Health recommends asking for a referral to a urogynecologist, an expert who focuses solely on these issues, to guide you through your best options.

Pelvic floor treatment often works best when different experts work together. Your primary care provider might team up with a gynecologist, urologist, or pelvic floor physical therapist to get a complete picture of what’s going on. This team-based model allows you to stay in control while exploring the least invasive options first.

• Many women wait years to seek help, but the earlier you act, the better your outcome — While mild prolapse is often monitored without immediate treatment, some cases of incontinence, or bowel control issues don’t improve on their own. Doing nothing often allows the problem to worsen. That’s why it’s important to seek early evaluation and tailored intervention before symptoms become too disruptive or irreversible.

Most Women Have No Idea Their Symptoms Are Treatable with the Right Therapy

In an interview by KTAL News, physical therapist Mary Watts Lazarone explained how pelvic floor issues are often hidden in plain sight.3 She shared that women routinely dismiss signs like bladder leaks during laughter, pelvic pressure, pain with intimacy, or difficulty going to the bathroom as “just part of being a woman.” But those symptoms often point to deeper problems, and they’re treatable with targeted therapy.

• The pelvic floor isn’t just one muscle; it’s an entire support system for your body’s core — Your pelvic floor is made up of a group of muscles that support your bladder, bowel, and reproductive organs. These muscles are essential for stability, bladder control, and sexual function. When they’re too weak or too tight, you start to experience problems like leaking urine, painful intercourse, or constipation.

• Pelvic floor therapy isn’t just about doing Kegels; it’s highly personalized and often hands-on — One of the biggest myths is the idea that pelvic floor issues are fixed with Kegel exercises alone.

“People think it’s just about doing Kegels,” Lazarone said, “but in many cases, the issue is actually too much tension.” Instead, pelvic floor therapy often includes manual therapy (hands-on muscle work), biofeedback, breathing exercises, posture correction, and core strengthening. Sessions are customized, one-on-one and designed around your body’s specific needs.

• Results usually come fast; many women notice a difference in just a few weeks — According to Lazarone, patients tend to improve within four to six weeks. “These are small muscles,” she explained. “Once we get the coordination back, we usually see results pretty quickly.” This kind of progress helps you rebuild confidence, reduce pain, and regain control over your bladder or bowels without medications or surgery.

• Postpartum recovery is one of the most overlooked aspects of pelvic health — For women who’ve recently had a baby, especially after a C-section or with abdominal separation known as diastasis recti — pelvic floor therapy plays a key role in recovery. Therapists guide patients through restoring strength, balance, and coordination across the core, hips, and back. This helps reduce long-term pain and improves posture, bladder control, and sexual comfort after birth.

How to Start Fixing the Root Cause

If you’re dealing with leaks when you laugh, pelvic pressure when you stand or digestive issues that don’t seem to resolve, it’s time to look at what’s actually causing the problem. Pelvic floor dysfunction doesn’t happen randomly; it’s the result of muscle imbalance, pressure overload, poor coordination, or in some cases, past trauma like childbirth or surgery.

But the good news is this: most of the time, you don’t need pills or surgery to fix it. You need to retrain the muscles, reduce the triggers, and start supporting your body in smarter ways. Here are five things I recommend you start doing right away if you want to begin healing from the inside out:

1. Rebuild pelvic coordination with a personalized therapy plan — If you’re leaking urine, having trouble with bowel movements or feeling pressure in your pelvis, it’s a sign that the muscles in your core are out of sync.

Kegels are useful but won’t cut it alone. What you actually need is a tailored pelvic floor therapy program that targets both weakness and tension. Manual therapy, biofeedback, and coordination training will help you relearn how to engage your pelvic muscles properly. Most women feel real progress in as little as four to six weeks.

2. Take pressure off your pelvic floor by managing your weight — If you’re overweight, you’re putting extra downward pressure on your bladder, bowel, and reproductive organs every single day. That weight weakens muscle support and accelerates prolapse and leakage. Start small by walking daily, reducing processed foods and eliminating vegetable oils that damage metabolic health. Lowering excess body weight is one of the most effective ways to reduce the strain on your pelvic floor.

3. Stop straining and fix your bathroom posture — If you’re pushing hard to poop or feel like you never fully empty your bowels, you’re likely aggravating the very muscles that should be helping you. Sit with your knees above your hips using a squat stool, breathe slowly to relax your core and give your body time.

4. Protect your pelvic muscles from tension overload — High-impact exercise, chronic stress, or even overdoing “core” workouts like crunches create excessive pelvic tension. If you’re always clenching your glutes or sucking in your stomach, you could be forcing your pelvic floor to overwork. Try switching to restorative movement like deep squats, slow breathing, and walking in nature. Letting go of constant muscle bracing is a powerful way to break the pain-tightness cycle.

5. Know when to get real support; don’t wait years like many women do — If you’ve had a baby, experienced pelvic trauma or simply feel like “things aren’t right down there,” don’t brush it off. Pelvic therapists see women from ages 15 to 80 and design treatments just for you. In many places, you don’t need a referral.

Book an evaluation, even if it’s just to ask questions. Getting assessed by someone who specializes in holistic pelvic health is one of the fastest ways to understand what’s going wrong and exactly how to fix it.

FAQs About Pelvic Floor Issues

Q: What are PFDs, and how common are they?
A: PFDs include bladder leaks, bowel control problems, and pelvic organ prolapse — when organs like the bladder or uterus shift out of place. According to research, 1 in 3 women seen in primary care has at least one of these conditions, with bowel dysfunction being the most common.4

Q: What causes pelvic floor dysfunction?
A: The most common drivers are aging, excess body weight, and vaginal childbirth. Other factors include chronic straining, past surgeries, hormonal shifts like menopause and even overactive pelvic muscles. These issues disrupt how your pelvic muscles contract, relax, and coordinate, leading to symptoms like leaking, pressure, or pain.

Q: Do I need surgery to fix a pelvic floor problem?
A: No. In most cases, surgery isn’t the first or best step. Non-surgical options including pelvic floor therapy, medications, nerve stimulation, and supportive devices like pessaries. Many women get significant relief with the right therapy plan and lifestyle changes.

Q: How do I know if I need pelvic floor therapy?
A: If you’re leaking urine during activities, feeling heaviness or bulging in your pelvic area, having trouble with bowel movements or experiencing pelvic pain, especially during sex, you could benefit from therapy. Pelvic floor physical therapy is tailored to your needs and leads to results within four to six weeks.

Q: What are the best things to do at home to start healing?
A: Start by addressing the root causes of pelvic floor dysfunction. Use a squat stool when using the bathroom to reduce strain during bowel movements. Avoid high-impact exercise if it seems to trigger or worsen your symptoms. Begin incorporating breathing and posture work into your daily routine to help relax overactive or tense pelvic muscles.

Walking each day is also a simple way to reduce inflammation and ease the downward pressure on your pelvic organs. Finally, consider seeking out a pelvic floor specialist. These steps support long-term recovery and help restore pelvic function without needing medications or surgery.

A New Series of Health Insights Is on the Way

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A New Series of Health Insights Is on the Way
Our team has been working behind the scenes to prepare new research and practical health strategies for our readers. While we finish preparing what’s coming next, we invite you to explore one of the most-read articles from our library below. See exactly what’s changing →

Your liver handles over 500 functions, from filtering blood and neutralizing toxins to regulating hormones and producing bile. If it’s constantly overburdened, which is increasingly the case in a world saturated with environmental toxins, medications, and ultraprocessed food, its health can suffer, and you’ll feel the effects all over your body.

In light of this, protecting your liver is important. While it can heal itself from damage,1 the chronic assaults will eventually take a toll, and before you know it, scarring has already occurred. Fortunately, there are several alternatives to protect liver function, and they come in the form of herbs.

7 Herbs to Help Support Your Liver

Taking a natural approach to promoting optimal liver function is ideal because you don’t have to rely on expensive pharmaceuticals. That said, The Hearty Soul shares seven herbs that have a long history of enhancing liver health:2

1. Milk thistle — One of the most famous herbs for liver health, milk thistle has a long history of use, dating back to over 2,000 years. According to an article published in StatPearls:3

“Milk thistle exhibits its hepatoprotective properties by 3 major mechanisms: an antioxidant, an anti-inflammatory, and an antifibrotic substance. The anti-inflammatory properties of milk thistle are attributable to its ability to regulate cytokines responsible for inducing inflammation. Milk thistle has been shown to down-regulate and inhibit the expression of COX-2, a key mediator of inflammatory pathways.”

2. Turmeric — An ingredient essential to making curry, this powerful spice contains curcumin, which research shows to possess antioxidants and anti-inflammatories.

While turmeric is easy to incorporate in most dishes, here’s a handy tip to improve its bioavailability — pair it with black pepper. It contains a bioactive ingredient called piperine, which synergizes with curcumin.

3. Barberry — While not a popular herb, The Hearty Soul notes that it’s one of the most powerful options for liver support. It contains a polyphenol called berberine, which “helps shield liver cells from oxidative damage and inflammation.”4 A meta-analysis5 in the Journal of Translational Medicine supports this hypothesis.

4. Dandelion root — Despite being classified as a backyard weed, this herb also contains antioxidants and other compounds that promote bile production. According to a study published in the Asian Pacific Journal of Tropical Medicine:6

“The anti-inflammatory effects of dandelion, the prebiotic effects of its oligofructans, inhibitory effects against the release of lipopolysaccharides and fasting induced adipose factor, digestive enzymes, and enhancing effects of lipogenesis, reduce lipid accumulation and liver inflammation, which directly or indirectly improve the liver functions.”

5. Ginger — One of the most diverse herbs used in cooking, ginger also has therapeutic qualities that benefit liver health. In a 12-week randomized clinical trial, researchers noted that ginger benefited patients diagnosed with fatty liver disease.7

6. Green tea — Research shows that this popular drink is rich in catechins that help lower liver fat levels. In a 12-week study performed by researchers, they noted that participants had better liver lipid profiles in addition to a reduction in body fat.8

7. Panax ginseng — Best known as an adaptogen, this herb also has hepatoprotective properties. In a 2023 meta-analysis, the researchers noted that bioactive compounds in panax ginseng reduced inflammation responses in the participants, which led to lower fat production. The gut microbiome also benefited from panax ginseng, which led to better liver fat metabolism.9

Additional Scientific Evidence Supports Herbal Solutions

Going deeper into science behind the different herbs that protect your liver, a meta-analysis published in Hepatology Forum analyzed their clinical effects on liver diseases, including fatty liver disease, hepatitis B, and alcoholic liver damage.10

• The standout herb was green tea — Again, green tea was noted for its catechins content. In one clinical trial reviewed, patients with nonalcoholic fatty liver disease (NAFLD) who took 1,080 milligrams (mg) of green tea catechins every day had a 42.1% drop in alanine aminotransferase (ALT), a well-known biomarker liver inflammation.

Alongside that, patients had a 31% reduction in urine 8-isoprostane, which is a chemical byproduct of oxidative stress that damages liver cells. These results didn’t take months or years to appear. The changes in liver enzymes and oxidative stress markers happened within 12 weeks.

• Milk thistle is another top performer — Silymarin, the active extract from milk thistle, was praised by the researchers. Multiple randomized controlled trials showed that silymarin improved liver enzymes like ALT and AST, while also reducing levels of malondialdehyde, another marker of oxidative stress.

In patients with alcoholic liver disease, milk thistle helped stabilize enzyme levels and reduced the rate of liver cell damage. This is especially relevant for people recovering from alcohol use or prescription medication overload, since both are known liver stressors.

• Berberine manages fat buildup in the liver — This herb was shown to not only improve liver enzymes but also regulate fat metabolism. In patients with metabolic syndrome or fatty liver, berberine helped normalize triglyceride levels and reduced liver fat buildup.

Berberine also activates an enzyme called adenosine monophosphate-activated protein kinase (AMPK), which acts like a metabolic switch. When AMPK is turned on, your cells burn fat more efficiently and reduce the accumulation of triglycerides in the liver. This helps reverse fatty liver from the inside out, rather than just masking symptoms.

• A multifaceted approach maximizes benefits — Each of the mentioned herbs affects a different pathway, which means they complement each other. For example, green tea scavenges free radicals before they can do harm, while milk thistle reinforces the liver’s cellular walls and promotes regeneration. Berberine targets the root of fat-related liver damage by balancing glucose and lipid metabolism.

Additional Strategies to Protect Your Liver

If you think you’ve been neglecting your liver health, there’s still time to turn things around. The earlier you get tested, the better your chances of repairing liver damage that can become permanent down the road. Hepatic problems are often silent, creeping only when the situation turns dire. To protect your liver, I recommend you follow these tips, in addition to incorporating the herbs mentioned earlier:

1. Eliminate vegetable oils and alcohol — These two are the top toxins that harm your liver. In light of this, if you’re still using anything labeled “vegetable oil” or eating ultraprocessed foods that contain soybean oil, corn oil, or canola oil on the label, you’re fueling a direct attack on your liver.

Vegetable oils are loaded with linoleic acid (LA), a polyunsaturated fat (PUF) that interferes with your cellular function and encourages fat buildup in liver tissue. The result? Chronic inflammation and a sluggish metabolism. It’s important that you swap them out right away in favor of healthy meals cooked in healthy fat, such as beef tallow, ghee, or grass fed butter.

Now, even if you’re eating a healthy diet, understand that LA is ubiquitous in the modern food supply. To protect your health, minimize your LA intake to less than 5 grams per day from all sources. If you can get it down to less than 2 grams per day, that’s even better for your health. I encourage you to download the upcoming Mercola Health Coach App, as it has a feature called the Seed Oil Sleuth — it will help you calculate the LA in your food up to a tenth of a gram.

Similarly, avoiding alcoholic beverages is paramount because it wreaks havoc through a process like LA. When your body tries to break down either alcohol or vegetable oils, it ends up creating destructive byproducts — acetaldehyde from alcohol and oxidized linoleic acid metabolites (OXLAMs) from LA. These are aldehydes, a class of unstable molecules that damage your cells, trigger inflammation, and disrupt liver regeneration.

If your bloodwork shows elevated liver enzymes or you carry noticeable weight around the midsection, cutting out both alcohol and industrial vegetable oils immediately gives your liver the breathing room it needs to recover.

2. Eat more choline-rich foods — Choline directs fat out of your liver. Without enough of it, fat doesn’t get packaged and sent to other places in your body that need fat and ends up accumulating in the liver. That buildup triggers inflammation and can eventually lead to fibrosis or even cirrhosis. The good news? You can turn this around with the right foods.

Egg yolks from pasture-raised chickens are one of the best sources of choline. Grass fed liver is another choline powerhouse, delivering a form your body absorbs efficiently. For context, choline is what your liver uses to create phosphatidylcholine — a compound required for exporting fat from liver cells.

3. Take a supplement if you’re not getting enough choline — If you’re limiting animal products due to health reasons, your choline intake is likely too low. Cruciferous vegetables offer some choline, but you’d have to eat plenty of them to get what your liver needs. In these cases, supplementing becomes a helpful adjunct to avoid fat accumulation.

While there are several types of choline supplements available, I recommend citicoline. Based on my research, it is one of the most overlooked forms of choline, mainly because previous supplements use ineffective dosages. But used at the right level — between 500 mg and 2,500 mg per day — it does far more than just cover a nutrient gap.

Citicoline helps your liver clear out fat more efficiently and boosts acetylcholine production, which your brain depends on for focus and memory. If you’re experiencing insulin resistance, mental fog, or liver dysfunction, this supplement supports detox and brain performance at the same time.

4. Stay active to shrink your waistline — You don’t need an intense workout routine to improve your liver health. Just move your body every day. Take a walk, do some stretching, or run through a basic bodyweight routine a few times per week. Movement helps lower insulin, increases blood flow to the liver, and supports overall metabolic health.

If your waist size is over 40 inches for men or 35 inches for women, that’s a sign that visceral fat — the dangerous kind that surrounds your organs — is accumulating. Incidentally, this type of fat is also tied to liver scarring and progression toward fatty liver disease.

Frequently Asked Questions (FAQs) About Herbs for Liver Health

Q: What are the best herbs to support liver health naturally?
A: Several herbs have been shown to support liver function through antioxidant, anti-inflammatory, and fat-regulating actions. Top choices include milk thistle, turmeric, barberry, dandelion root, ginger, green tea, and panax ginseng.

Milk thistle helps regenerate liver cells and lower enzyme levels. Green tea catechins reduce liver fat and inflammation. Barberry, which is rich in berberine, activates fat-burning pathways and lowers liver fat. Dandelion and turmeric also assist with bile production and reduce oxidative stress.

Q: Can herbs reverse liver damage from fatty liver or alcohol?
A: Yes. For example, green tea catechins reduced alanine aminotransferase — a liver enzyme linked to inflammation — by over 42% in just 12 weeks. Berberine has been shown to regulate fat metabolism and reduce liver triglycerides, helping reverse fatty liver. Milk thistle’s silymarin has helped stabilize liver enzymes and protect against further alcohol-related damage.

Q: What lifestyle habits worsen liver health and need to be stopped immediately?
A: Two of the most damaging habits are consuming vegetable oils (like soybean, corn, and canola oils) and drinking alcohol. Both produce harmful byproducts — OXLAMs from vegetable oils and acetaldehyde from alcohol — that directly damage liver cells, disrupt detox pathways, and accelerate aging. These compounds lead to fat buildup, inflammation, and eventually scarring.

If your waistline is expanding, your enzymes are elevated, or you’re feeling sluggish, removing both from your life is one of the fastest ways to let your liver recover.

Q: Why is choline important for liver function, and where can I get it?
A: Choline is required for your liver to package and export fat to cells throughout your body. Without enough choline, fat accumulates in the liver and can lead to inflammation, scarring, and fatty liver disease.

Egg yolks from pasture-raised chickens and grass fed beef liver are excellent natural sources. If your diet lacks animal products, you likely aren’t getting enough choline. In that case, supplementation, particularly with citicoline, will help restore fat metabolism and even improve cognitive function.

Q: How does exercise impact liver health, and what type is best?
A: You don’t need intense workouts — daily movement is enough to improve liver function. Walking, light stretching, or a few strength routines per week can lower insulin, improve circulation to the liver, and reduce dangerous visceral fat.

By the time memory loss appears, Alzheimer’s disease has already been developing for 20 years or more, and the earliest warning signs show up not in your brain, but in your gut. New research suggests that constipation, bloating, and digestive irregularity aren’t separate from cognitive decline. They may be the first chapter of the same story.

This timeline changes everything. If the disease starts decades before the first missed word or forgotten name, then waiting for memory symptoms is forfeiting your best window to act. The opportunity to intervene exists much earlier, in a system most people don’t associate with brain health at all: the gut.

This shift in understanding comes from research examining how Alzheimer’s actually unfolds over time — not just where the disease ends up, but where it begins and how it travels. What the findings reveal is that digestive changes, nerve signaling in your gut, and the balance of bacteria living inside you are not separate issues from brain health. They are part of the same story.

At the center of this story is butyrate, a short-chain fatty acid (SCFA) produced when friendly gut bacteria ferment certain fibers you eat. Your body is built to generate butyrate on its own, provided your gut bacteria have what they need to produce it. New research suggests butyrate plays a much larger role in brain protection than scientists understood even a few years ago.

When your gut produces enough of it, the downstream cascade that leads to cognitive decline slows. When production falters, which happens easily with modern diets and lifestyles, that protection disappears. To understand how this unfolds step by step, and what you can do to shift the trajectory in your favor, it helps to look closely at what researchers uncovered about where Alzheimer’s begins and how it spreads.

Your Gut Is Where Alzheimer’s Damage Quietly Begins

To understand how early gut changes set the stage for what happens decades later in the brain, researchers turned to a model that could track the disease from its very first whispers. The study, published in Molecular Psychiatry, investigated how amyloid-beta, a sticky protein fragment that builds up between brain cells, accumulates outside the brain and affects both gut and brain function over time.1
Scientists used a well-established Alzheimer’s mouse model to follow disease progression from early stages. Instead of starting with memory loss, they focused on what happens in the digestive system first. Researchers set out to identify whether stopping damage early in the gut changes what happens later in the brain. Keep in mind these findings are from laboratory and animal research and may not directly apply to human health.

• Early gut damage showed up before any memory decline — The animals in this study developed clear gut problems long before they showed signs of cognitive decline. These included slowed digestion and disrupted nerve signaling in the gut.
• Amyloid buildup damaged the gut’s nerve network — Amyloid-beta actively broke down communication between nerve cells. It reduced key proteins that allow nerve cells to “talk” to each other. When those signals break down, the gut loses coordination. That’s when symptoms like constipation and irregular digestion begin to show up.
• The imbalance between production and cleanup drove the problem — Researchers identified two shifts happening at the same time. First, enzymes that create amyloid-beta became more active. Second, enzymes responsible for clearing it out became less effective. Think of this like a sink where the faucet is turned on full blast while the drain is clogged. The buildup becomes unavoidable, and over time, it spreads beyond the original location.
• Amyloid traveled beyond the gut and reached the brain — One of the most important findings showed that amyloid-beta moved from the gut into the bloodstream and then into the brain. This explains how a digestive issue turns into a neurological one. When this transfer occurred, it was followed by inflammation and measurable memory decline in the animals.
• Butyrate stopped the process at multiple stages in the mouse model — When researchers introduced butyrate, it reduced amyloid levels in the gut, blood, and brain at the same time. It also preserved the structure of the gut’s nerve network and prevented the digestive slowdown seen in untreated animals. This suggests addressing the gut early changes the trajectory of the disease.
Butyrate reduced neuroinflammation, which is the immune system’s overreaction inside the brain. Lower inflammation meant less damage to brain cells and better preservation of memory function. That means the brain stayed more stable because the initial trigger in the gut was controlled. The compound also reduced the activity of enzymes that generate amyloid-beta while supporting those that break it down.
On a biological level, butyrate helped maintain the proteins that support nerve communication. It prevented the breakdown of synaptic connections, which are the links that allow nerve cells to send signals. When those connections remain intact, both gut function and brain signaling stay stable.
This is the crux of the whole picture. For decades, Alzheimer’s research assumed the disease originated and stayed in the brain. This finding reframes it entirely. The brain may be the destination, but your gut appears to be the starting line.

Butyrate Strengthens the Gut Barrier and Calms Brain Inflammation

While the first study traced how the damage starts and spreads, a second line of research reveals why butyrate is so effective at stopping it. The study, published in Nutrients, analyzed how butyrate influences inflammation, gut integrity, and brain health.2
Instead of focusing only on amyloid buildup, this research looked at how the environment surrounding your cells changes when butyrate levels rise. The goal was to understand how this compound helps stabilize systems that break down during neurodegenerative disease.

• The findings showed stronger gut protection and lower inflammation — Individuals or models with higher butyrate levels had better gut barrier integrity and reduced inflammatory signaling. In simple terms, the gut lining stayed tighter and more controlled. That matters because a weakened gut barrier allows harmful substances to leak into circulation, which adds stress to your brain and accelerates damage.
• Butyrate improved the physical structure of the gut lining — Butyrate acts as a primary fuel source for the cells lining your colon. When these cells receive enough energy, they stay intact and function properly. This leads to tighter junctions between cells, meaning fewer gaps where toxins or inflammatory molecules can pass through.
• Inflammatory signals dropped at both local and systemic levels — The researchers observed a clear reduction in pro-inflammatory markers, which are chemical signals that drive immune overreaction. Lower levels of these markers reduce stress not just in your gut, but throughout your entire body. That includes the brain, where inflammation directly interferes with normal cell communication and function.
Improvements in gut integrity and inflammation occurred alongside sustained exposure to butyrate, showing that consistent levels matter. The benefits build over time as your gut environment stabilizes. That means long-term habits that support butyrate production lead to steady protection rather than short bursts of improvement.
• Butyrate directly influenced communication between the gut and brain — On a deeper level, the research explained that butyrate interacts with signaling pathways that connect your gut to your central nervous system. These pathways regulate how information travels between your digestive system and your brain. When butyrate is present, those signals stay balanced and less inflammatory.
It also supported the blood-brain barrier, which acts like a filter that controls what enters your brain from circulation. The study showed that butyrate helps maintain this barrier, keeping harmful substances out while allowing nutrients through. When this barrier stays intact, brain cells operate in a more stable environment with less external stress.

• Cell-level protection came from energy and signaling support — Mechanistically, butyrate works by fueling cells and activating pathways that reduce inflammation and oxidative stress, damage from unstable molecules called free radicals that corrode cell structures over time — the cellular equivalent of rust. By lowering this stress and improving energy production, butyrate creates conditions where cells maintain function instead of breaking down.

5 Shifts That Rebuild Your Gut’s Brain-Protective Capacity

The damage linked to memory loss doesn’t start in your brain; it starts in your gut, long before you notice anything is wrong. What you’re dealing with is a slow chain reaction. It starts with a disrupted gut environment, progresses through inflammation and nerve damage, and then shows up as cognitive decline.
When you shift your focus to restoring your gut, you’re stepping in early enough to break that chain before it reaches your brain. If your gut isn’t producing enough butyrate, you’re missing one of the most powerful built-in systems your body uses to regulate inflammation, protect nerve signaling, and support metabolic stability.
My paper, “SCFAs Modulate Gut-Brain Axis Function,” explains that SCFAs like butyrate act as direct messengers between your gut and brain, helping coordinate immune balance, inflammation control, and neurological function. When this system breaks down, which happens with modern diets low in supportive nutrients and high in inflammatory fats like linoleic acid (LA), that communication collapses, and chronic inflammation takes over.

1. Assess your gut health before you change anything — Start by getting honest about your current baseline. If you struggle with bloating after meals, frequent constipation, loose stools, or a long list of foods you can’t tolerate, your gut is already under strain. If three or more of those apply to you, your system needs a reset, not more complexity. Knowing where you stand helps you avoid pushing too hard too fast, which only makes symptoms worse.
2. Simplify your diet to calm your gut before rebuilding it — Counterintuitively, piling on fiber when your gut is already inflamed often makes things worse. Beans, raw vegetables, and whole grains ferment rapidly in an imbalanced gut, feeding the wrong bacteria and generating gas, pressure, and more irritation.
Instead, focus on simple, easy-to-digest foods like fruit and white rice. These give your body steady fuel without feeding the imbalance. As your symptoms improve, gradually expand from there in a controlled way.
3. Reintroduce the right fibers slowly to rebuild butyrate production — Once your gut stabilizes, begin feeding the bacteria that produce butyrate. Start small. Cooked and cooled potatoes or green bananas provide resistant starch, which reaches your colon intact and fuels beneficial microbes.
From there, layer in foods like onions, garlic, and leeks. These act as targeted fuel for bacteria that generate SCFAs. If tolerated, fermented foods like sauerkraut or kefir help increase diversity, which strengthens your entire system and restores that gut-brain signaling loop described in the research.
4. Eliminate vegetable oils that damage your gut bacteria — If your meals include soybean, corn, canola, or sunflower oil — or the processed foods that contain them — you’re actively working against your gut recovery. These fats, rich in LA, disrupt the microbial balance required for butyrate production and amplify inflammation. Replace them with stable fats like grass fed butter, ghee, or tallow. This shift changes your internal environment in a way that supports bacterial balance instead of destroying it.
5. Use daily habits to reinforce a gut environment that produces butyrate — Your gut responds to more than food. Morning sunlight helps regulate your internal clock, which directly influences gut function and microbial rhythms. Stopping food intake at least three hours before bed gives your digestive system time to reset.
Managing stress through simple actions like walking or controlled breathing supports your nervous system, which in turn supports your gut microbes. When these daily inputs align, your body restores its ability to produce butyrate and maintain a stable gut-brain connection.

FAQs About Butyrate and Your Brain

Q: How is my gut connected to Alzheimer’s disease?
A: Your gut and brain are directly linked through what researchers call the gut-brain axis. Research shows that amyloid-beta, the protein tied to Alzheimer’s, builds up in your gut before it appears in your brain. This buildup damages the nerve network that controls digestion and then spreads through your bloodstream, eventually reaching your brain and contributing to memory decline.

Q: What is butyrate and why does it matter for my brain?
A: Butyrate is a SCFA your gut bacteria produce when they’re properly fed. It acts like a fuel source for your gut lining and a signaling molecule between your gut and brain. When your body produces enough butyrate, it helps reduce inflammation, protect nerve connections, and maintain stable communication between your digestive system and your brain.

Q: What happens when my body doesn’t produce enough butyrate?
A: When butyrate production drops, your gut barrier weakens and allows harmful compounds to enter your bloodstream. This increases inflammation throughout your body, including your brain. Over time, this creates the conditions that drive nerve damage, disrupt communication between cells, and accelerate cognitive decline.

Q: What are early warning signs my gut is affecting my brain?
A: Digestive symptoms often appear long before memory problems. Common signs include constipation, bloating, irregular bowel movements, and difficulty tolerating certain foods. These symptoms reflect changes in your gut’s nerve signaling and microbial balance, which are directly tied to the same processes that later impact brain function.

Q: What is the most effective way to increase butyrate naturally?
A: The most effective strategy is to rebuild your gut environment so your bacteria can produce butyrate on their own. That includes simplifying your diet if your gut is inflamed, gradually reintroducing fermentable fibers like resistant starch, eliminating vegetable oils that disrupt microbial balance, and supporting daily habits like consistent meals, sunlight exposure, and stress management.
Done consistently, these steps may help support the entire internal environment your brain depends on for decades of stable function.

This article is for informational purposes only and does not constitute medical advice. Consult a qualified healthcare provider before making changes to your health regimen.

Test Your Knowledge with Today’s Quiz!
Take today’s quiz to see how much you’ve learned from yesterday’s Mercola.com article.

Where is cytochrome c oxidase (CCO) located in the cell?

Inside the nucleus
In the mitochondria
Cytochrome c oxidase (CCO) is found in the mitochondria, where it helps produce energy and supports antioxidant defense pathways. Learn more.
In the cell membrane
In the cytoplasm

1 Slower weight gain is mainly caused by what effect of semaglutide and salcaprozate sodium (SNAC)?

Faster metabolism increasing calorie burn
Reduced appetite leading to lower food intake
Semaglutide and salcaprozate sodium (SNAC) reduce appetite, leading to lower food intake, which slows weight gain rather than increasing calorie burn. Learn more.

Increased muscle growth raising body weight
Improved digestion absorbing fewer calories

2 Which of the following is not a typical symptom of long COVID?

Persistent fatigue and poor sleep
Shortness of breath and brain fog
Low-grade fever every 3 days
Long COVID commonly includes fatigue, brain fog, and breathing issues. A recurring fever every few days is not a typical or defining symptom. Learn more.

Muscle weakness and reduced stamina

3 How long can antibiotics affect your gut microbiome?

Up to 8 years
Antibiotics can alter your gut bacteria for up to eight years, with long-term effects on digestion, metabolism, and immune function. Learn more.

More than 6 months
Close to a year
Varies from two to three years

4 What is the chain reaction that destroys immune cell membranes?

Ferroptosis
Ferroptosis is a form of cell death driven by fat oxidation, which damages cell membranes and weakens immune cells. Learn more.

Glycolysis
Oxidation
Lipogenesis

5 Which of the following is not a main driver of liver fibrosis?

Excess abdominal fat
Poor blood sugar control
Multiple metabolic risk factors
High water intake
Liver fibrosis is driven by metabolic stress like excess fat and poor blood sugar control. High water intake does not contribute to liver scarring. Learn more.

6 Which one is a real symptom of an enlarged prostate (BPH)?

Sharp chest pain during breathing
Frequent urination, especially at night
Benign prostatic hyperplasia (BPH) commonly causes frequent urination, urgency, weak flow, and nighttime bathroom trips due to pressure on the bladder. Learn more.

Sudden vision loss in one eye
Persistent coughing throughout the day

7 What makes the brain especially vulnerable to oxidative damage?

It stores large amounts of fat for energy that eventually oxidize
It has very low energy and a very thin blood-brain barrier
It contains mostly water with few active cells
It uses about 20% of the body’s oxygen and energy
The brain uses about 20% of the body’s oxygen and energy, producing more oxidative byproducts that increase the risk of cellular damage. Learn more.

Test Your Knowledge with
The Master Level Quiz

1 Which group of bacteria is linked to increased inflammation in the gut?

DesulfovibrionaceaeDesulfovibrionaceae produce hydrogen sulfide, which irritates the gut lining and weakens its protective barrier, promoting inflammation. Learn more.
Lactobacillus
Bifidobacterium
Akkermansia

2 What level of radiofrequency radiation (RFR) has been linked to gut microbiome changes?

2.4 GHz RFR
3.5 GHz RFR
4.9 GHz RFRExposure to 4.9 GHz radiofrequency radiation altered gut bacteria, reduced diversity, and changed metabolic profiles. Learn more.
6.0 GHz RFR

3 By how much did butyrate levels drop with salcaprozate sodium (SNAC)?

About 30%
By almost 80%SNAC reduced butyrate levels by about 77%, nearly an 80% drop, weakening gut lining integrity and reducing fuel supply for colon cells. Learn more.
Less than 50%
By over 90%

4 How does hydrogen help restore energy and strength at the cellular level?

It works as a selective antioxidantHydrogen acts as a selective antioxidant, neutralizing harmful free radicals like hydroxyl radicals while preserving beneficial ones needed for normal cell function. Learn more.
It increases all free radicals in the body
It boosts carbon dioxide production in cells
It helps metabolize lipids more efficiently

5 Which neurotransmitter acts as the brain’s main “brake pedal,” calming nerve activity?

Corticotropin-releasing factor (CRF)
5-hydroxytryptamine (5-HT)
N-Acetylaspartylglutamate (NAAG)
Gamma-aminobutyric acid (GABA)Gamma-aminobutyric acid (GABA) slows excessive brain activity, helping regulate mood, sleep, and stress. Low levels are linked to anxiety, poor sleep, and neurological issues. Learn more.

6 How does honey help relieve throat inflammation?

It increases mucus production in the throat
It dries out the throat to reduce irritation
It coats the throat and suppresses coughingHoney coats the throat and acts as a natural cough suppressant, helping reduce inflammation and irritation, especially at night. Learn more.
It blocks all bacteria instantly in the airway

7 What type of foods may help rebuild the gut after antibiotic use?

Highly processed foods and refined sugars
Simple whole foods, including complex carbohydratesSimple whole foods with complex carbohydrates help restore gut bacteria, support the gut lining, and improve overall microbial balance after antibiotics. Learn more.
High-fat foods that follow the principles of the ketogenic diet
Artificial sweeteners and packaged snacks

8 How many Americans are affected by arthritis?

53.2 millionAbout 53.2 million Americans live with arthritis, making it one of the most common causes of joint pain, stiffness, and reduced mobility. Learn more.
10.8 million
23.1 million
80.9 million

9 Why may fruits help protect against tinnitus?

They increase blood sugar for energy
They improve digestion in the stomach
They add more calories to the diet
They provide antioxidants that protect ear cellsFruits are rich in antioxidants like vitamin C and polyphenols, which help reduce oxidative stress and protect the inner ear from damage linked to tinnitus. Learn more.

10 Which of the following is a source of unhealthy fats in modern diets?

Organic fruits
Pastured eggs
Restaurant mealsRestaurant meals and packaged chips are often cooked in seed oils high in unhealthy fats. Organic fruits contain little to no fat, making them an unlikely source. Learn more.
Home-cooked whole foods

11 How much creatine does the body naturally produce each day?

1 to 2 gramsThe body produces about 1 to 2 grams of creatine daily from amino acids, helping support cellular energy and overall function. Learn more.
5 to 10 grams
10 to 15 grams
0.5 grams

12 What is the active ingredient in Benadryl?

DiphenhydramineBenadryl contains diphenhydramine, an older antihistamine that can cause sedation and other side effects, with newer alternatives now considered safer. Learn more.
Loratadine
Cetirizine
Fexofenadine

13 What type of fat is stored deep around your organs and drives inflammation?

Subcutaneous fat
Brown fat
Intramuscular fat
Visceral fatVisceral fat surrounds organs and releases inflammatory signals, disrupting blood sugar control and increasing the risk of liver damage over time. Learn more.

14 What is the most common cause of tight hips?

Drinking too much water
Sleeping too many hours
Prolonged sittingSitting for prolonged periods keeps hip flexors shortened and weakens glutes, reducing blood flow and leading to stiffness and poor movement control. Learn more.
Eating a high-protein diet

15 What process triggered by intermittent fasting contributes to hair loss?

LipolysisIntermittent fasting increases lipolysis, releasing fatty acids that create oxidative stress, which can damage hair follicle stem cells and disrupt hair growth. Learn more.
Glycolysis
Protein synthesis
Cell hydration

16 What is the main function of fibroblasts in the body?

They produce hormones that regulate metabolism
They break down damaged cells in tissues
They transport oxygen through the bloodstream
They produce collagen to build connective tissueFibroblasts are repair cells that produce collagen, helping form and maintain connective tissue, but excess activity can lead to tissue thickening. Learn more.

17 How much protein is recommended after a workout?

About 20 to 40 gramsConsuming 20 to 40 grams of protein after exercise supports muscle repair and recovery when muscles are most ready to absorb nutrients. Learn more.
About 5 to 10 grams
About 50 to 70 grams
No protein is needed

18 Which of the following does not cause exercise headaches?

Increased blood flow to the head
Rapid rise in workout intensity
Pressure buildup inside the skull
Adequate hydration levelsExercise headaches are linked to increased blood flow and pressure in the head. Proper hydration helps prevent them and is not a cause. Learn more.

19 Which statement about near-infrared (NIR) light is not true?

It is absorbed by mitochondria to support cellular energy
It only works through vitamin D production in the skinNear-infrared light acts on mitochondria, not through vitamin D. This pathway supports energy production and antioxidant defense independently. Learn more.
It helps trigger local melatonin production in cells
It supports antioxidant protection in the brain

20 What are the two most common underlying causes of chronic illness?

Cold weather and inactivity
Lack of sleep and dehydration
Low protein and low fat intake
Toxicity and poor gut healthChronic illness often stems from cellular dysfunction driven by toxicity and poor gut health, which disrupt normal body processes over time. Learn more.

21 What happens when the body doesn’t have enough iron?

Red blood cell production decreasesIron is essential for making red blood cells. Without enough iron, production drops, reducing the body’s ability to carry oxygen efficiently. Learn more.
Red blood cells increase rapidly
Blood becomes thicker and clots more
Oxygen levels rise in the blood

Editor’s Note: This article is a reprint. It was originally published May 1, 2022.

Dr. David Minkoff is a pioneer in natural medicine with an active practice in Clearwater, Florida. In this interview, we dive deep into some of his best strategies to optimize your health and resolve common health challenges that conventional medicine is incapable of resolving.

Like me, he’s passionate about exercise and has been an avid athlete since his youth. He has completed numerous Ironman competitions over the course of his athletic career.

“Most of my practice is chronically ill people, but I have worked with some very high-end athletes, and I can really help them because I understand what kind of metabolism you need to do to be able to perform consistently at a high level,” he says. “I’ve sort of been in the laboratory myself, and that’s been very helpful.”

Minkoff’s Journey

Minkoff has had a rather eclectic medical training, including adult and pediatric infectious disease. In 1995, his wife, a registered nurse, took him to a series of Jeffrey Bland lectures, a pioneer in nutritional biochemistry, and the rest, as they say, is history.

“My lights just went on,” Minkoff says. “It was just like, ‘Holy smokes, this guy is smart, and it makes sense, and I want to learn this.’ So, I started going to courses. I went to ACAM [American College for Advancement in Medicine] and learned how to do chelation.”

After that, he trained with Dr. Dietrich Klinghardt, a pioneering physician in alternative medicine and Lyme disease specialist; Dr. Yoshiaki Omura, a general practitioner, cardiologist, and president of the International College of Acupuncture and Electro-Therapeutics; and Dr. Thomas Rau, a Swiss doctor specializing in biological medicine.

“As I got into it, I just sought out the best people that I could find to help me learn how I could do this better,” Minkoff says. “That’s been 25 years. So, I left the emergency room in 2002, and we’ve been going gang busters since then.

We have a very big practice now, and it’s so much fun because there are so many new ways to help people get better that actually solve the problem with their bodies.

… If you have a chronic illness — high blood pressure, high cholesterol, rheumatoid arthritis, Parkinson’s disease — the repertoire of standard medicine is not very good. They might help you with symptoms, which is fine for a while, but you are headed toward an endpoint, which isn’t going to be what you want.

We have seven hyperbaric chambers. We’ve been doing it for years. It’s a wonderful treatment … We’ve been doing methylene blue for about five years … Then, I learned about intranasal NAD — fascinating. The field is exploding with amazing people who are coming up with things that help people and have practically zero downside.”

2 Key Root Causes

Chronic illness is typically caused by some underlying cellular dysfunction, and two of the primary reasons for that are toxicity and/or poor gut health. Minkoff explains:

“Half the problem is things in the body that shouldn’t be there, and the other half is things missing from the body that should be there. In some cases, there’s mechanical stuff.

We need chiropractors, acupuncturists, massage therapists or things like this because there’s a joint out of place, or their cervical vertebrae are out of place. Sometimes they might even need surgical intervention.

But the big two are, you’re toxic and you’re depleted. My approach to people then is: What are those things, and then, what is the priority or the order of dealing with those things?”

When it comes to detoxification, many things can go wrong, so it needs to be done under the supervision of a skilled practitioner. The use of DMPS, for example, can be very rough on your kidneys, and if your body is not capable of excreting the toxins, releasing them from the tissues where they’re trapped will make you far worse rather than better.

Making a Diagnosis

When Minkoff sees a new patient, he has them fill out an extensive and detailed medical history, including dental history. Then, he performs a detailed physical exam, followed by autonomic response testing, which allows him to identify various triggers, such as toxins and infections.

“The body is so sophisticated that it will give you a sort of readout of ‘Here’s my priority levels. Do the root canals first. Handle the cavitations. Oh, yes, there’s a parasite there. There’s autoimmune there. I’ve got chronic Epstein Barr virus or herpes Type 6,’” Minkoff explains.

Autonomic response testing will also identify specific pathogens that are causing problems. In the interview, Minkoff gives a number of examples of patients whose health problems were resolved once the specific pathogen was identified and treated.

With oxygen, you can stimulate a body to heal. You can stimulate a joint cartilage to grow. You can stimulate a tendon to strengthen and you can stimulate an immune system to get stronger. You can kill off bugs, Lyme, and put viruses at bay. It’s just a massive game changer. ~ Dr. David Minkoff

Oftentimes, an infected root canal is found to be the offender. Minkoff has a biological dentist nearby. If a dental problem is suspected, he’ll send the patient there for a three-dimensional cone beam CT scan, which can clearly identify any problem areas that aren’t visible using a two-dimensional X-ray. Another really helpful diagnostic is darkfield blood analysis (aka, live-cell microscopy), which Minkoff learned to use under Rau.

“I find that it’s very helpful because sick people have bad-looking blood,” he says. “Their physical examination is often fine, their reflexes are fine, their heart sounds fine and their liver and kidney are fine [but they feel terrible] … We throw the blood up on there and look at it and we’re like, ‘Holy smokes.’ There are bio-films all over, there’s fibrin deposits and there’s organisms …

Two months later, ‘Hey, look at this blood. This blood’s looking better.’ And two months later, ‘This blood is really looking normal’ … That’s a complete picture where we are restoring healthy physiology to this person and that’s what health is.”

Available Treatment Modalities

When it comes to treatment, Minkoff has a number of interesting modalities at his disposal, including prolotherapy, ozone therapy, prolozone (a combination of prolotherapy and ozone), hyperbarics, chelation, UVBI (ultraviolet blood irradiation), EBOO (extracorporeal blood oxygenation), photobiomodulation, and much more.

Minkoff also offers VSELs [very small embryonic like] stem cell treatment, and it too has potent effects. Minkoff uses it himself and attributes gaining 7 pounds of lean body mass without change in his training to VSELs. He was trained in the use of VSELs by Dr. Todd Ovokaitys in San Diego.

Dr. Frank Shallenberger is the physician who trained him in ozone administration. Minkoff and I have both spoken at Dr. Shallenberger’s ozone certification courses. If you know any clinicians interested in this modality, encourage them to look into his training programs, which are designed for medical professionals.

Benefits of Extra Corporeal Oxygen and Ozone (EBOO) Therapy

EBOO is a potent way to administer ozone. It is even more effective than 10 pass ozone, but most people have to start slowly and work their way up to it. After becoming fascinated with this treatment, I encouraged Tom Lowe to make the units available commercially in the U.S. Minkoff explains:

“EBOO is a way to deliver oxygen and ozone to the body in a setup that’s like dialysis. One IV goes into one arm, it goes through a machine that has a pump, so it can pull the blood out of the body. It goes through a system where the blood is exposed to oxygen in very high concentrations and ozone in low concentrations, and then it’s recycled back to the body.

Some of the new machines also expose the blood to ultraviolet light. For about an hour, the blood circulates through this machine and is highly oxygenated. It isn’t really filtered like dialysis would be, but it’s exposed to this high oxygen concentration.

And — I don’t exactly understand how it happens — but there is a runoff container where if you are really sick and toxic, you get a lot of this runoff collected in this container. Sometimes it’s foamy and yellow. Our record is 2,000 CCs of this foamy liquid in a really sick person …”

Sauna therapy is another excellent intervention with powerful therapeutic benefits. We didn’t get a chance to dive deep into sauna treatment but I have published an in-depth deep dive on saunas with specific recommendations on how to identify and/or build one of the best saunas in the world — a therapy I believe most people can benefit from.

How to Raise NAD Naturally

If you don’t have access to IV NAD treatment or can’t afford it, there are three ways to raise your NAD level naturally: calorie restriction (or time-restricted eating, which achieves the same thing, but is safer), aggressive exercise, and sauna therapy.

If you do those three things, you’ll activate NAMPT, which is a precursor to NAD. You could then use low-dose niacinamide (not niacin). An ideal dose is around 50 mg, three times a day. This will give you the raw material your body needs to produce NAMPT. I did an excellent interview with molecular biologist Nichola Conlon on this topic which you can find on my Substack.

“I put a lot of people with mitochondrial issues on [niacinamide], and I found that it’s helpful,” Minkoff says. Niacinamide is also extremely cost-effective. It’ll run you about 25 cents a month, whereas other NAD precursors such as NMN can cost you $100 a month or more.

Plasmalogen and Iron Testing

Minkoff also uses a lipid test developed by lipid biochemist Dayan Goodenowe, author of “Breaking Alzheimer’s.” “I’ve learned a ton from him, and we do his test on everybody,” Minkoff says.

“He’s got a lab now that can measure levels of plasmalogens. They’re very integral pieces of cell membranes, and he’s got some very nice data about people with APOE4 on a track of memory loss.”

Patients with low plasmalogen levels can be given supplements such as fossil lipids to prevent further deterioration of their neurological function. Minkoff also measures ferritin and iron binding on all patients, and if their hemoglobin is high, he prescribes blood donation to lower their stored iron. Stored iron is incredibly destructive, as it causes oxidative stress, and is a commonly overlooked factor in deteriorating health.

Basic Health Guidance

While getting a full workup is the best way forward if you have a chronic health problem, three basic recommendations that can improve your health include:

• Cleaning up your diet — Focus on whole organic foods, and avoid any and all processed foods, including restaurant fare.

• Optimize your sleep — A sleep tracker can be very useful to ensure you’re getting good sleep.

• Getting regular exercise — While cardio is important, strength training should be at the top of your list, especially as you get older, as having muscle mass optimizes you for longevity and reduces your risk of insulin resistance and diabetes.

Editor’s Note: This article is a reprint. It was originally published March 10, 2024.

In this interview, Christy Sutton, D.C., reviews the dangers of excessive iron. While most doctors look for iron deficiency, few ever pay attention to elevated iron. Sutton is the author of two books, “Genetic Testing: Defining Your Path to a Personalized Health Plan: An Integrative Approach to Optimize Health,” and “The Iron Curse: Is Your Doctor Letting High Iron Destroy Your Health?”

Iron plays an important role in health, especially for children and young adults. Without sufficient iron, you’re not going to be able to form red blood cells and certain proteins in your mitochondria that are responsible for producing energy. On the flip-side, an excess of iron can cause significant damage.

A Silent Epidemic

Sutton’s interest in iron has been “lifelong” she says, as she struggled with low iron while her husband has a genetic anomaly that causes him to have elevated iron levels. So, she has personal experience with both ends of the spectrum.

“I have Crohn’s [disease], celiac, and lost part of my small intestine due to Crohn’s when I was 16,” she says. “Because of that, I have to take a bile sequestrant. Then, being [a] menstruating female who’s had a child, low iron has been something that I have been watched very closely for and I had to take iron a lot.

Like a lot of clinicians, when I came into practice, I seemed to be more hyper-focused on people’s problems that were my own problems. I dealt with iron issues. So, I wanted to watch my patients’ iron levels closely. Then I realized, ‘Oh, not everybody is low. A lot of people actually have high iron.’

It wasn’t until I was writing my first book, ‘Genetic Testing: Defining Your Path to a Personalized Health Plan,’ that I discovered the hemochromatosis genes. I realized that my husband had a hemochromatosis gene, and I realized that that was why I kept telling him to donate blood.

His doctor would order iron labs, ferritin, CBC, and he would get elevated iron often, high ferritin. He was developing high liver enzymes and his red blood cells were getting high as well, which is a common issue with people that have too much iron …

He went to a gastroenterologist, because he was trying to figure out why his liver enzymes were high. I thought it was the high iron, but that was presented to the gastroenterologist and dismissed. So, they went down this rabbit hole of misdiagnosing him with autoimmune hepatitis.

Later we went to a hematologist where we figured out he had hereditary hemochromatosis. So, it’s not something that’s particularly difficult to treat. Removing blood, diet supplements, things like that can help.

But once I got really savvy about looking for the genes and the labs combined, I realized that this is a silent epidemic that is not really being talked about. I would tell people, ‘You have a problem with high iron,’ and then they would often go and get a second opinion.

Their second opinion would say, ‘You’re fine. Don’t worry about it,’ which is a common issue where people are getting high iron labs that should warrant more investigation and then they’re just getting dismissed.”

How to Lower Your Iron Level

I have beta thalassemia, a hemolytic anemia that results in a high turnover of red blood cells. My red blood cells only live about two months, rather than the normal three months. As a result, my iron tends to accumulate because of the rapid turnover. So, while I do not have the hemochromatosis gene, it results in similar problems. I inherited it from my father, who had a ferritin level close to 1,000 by the time he was diagnosed. Ideally, it should be below 40.

One of the supplements he tried was inositol, also referred to as hexaphosphate or IP-6, but it did nothing. I rapidly came to the conclusion that the supplements typically recommended for high iron are useless and in some cases even dangerous, because they prevent you from doing what is really helpful, which is to remove iron through regular phlebotomies.

The most effective way to lower your iron is to donate blood two to four times a year. If losing 10% of your blood in one sitting is problematic for you, then you can remove blood in smaller amounts once a month on the schedule I have listed below. If you have congestive heart failure or severe COPD, you should discuss this with your doctor, but otherwise this is a fairly appropriate recommendation for most.

Men
Postmenopausal Women
Premenopausal Women

150 ml
100 ml
50 ml

As it turns out, Sutton did not include IP-6 in her book, as she couldn’t find any research to back up the claims. She doesn’t dismiss all supplements, however. One of the most helpful, in her view, is curcumin.

“Clinically, I have seen curcumin’s ability to lower iron almost to a fault,” she says. “It’s annoying to me, because I can’t take curcumin for inflammation because it makes me low in iron. But for people that are high in iron or even inflamed with high iron, high ferritin, that’s a great place to start, because curcumin binds to iron.

It also has all of these other wonderful health promoting properties. It’s so good for your brain — it actually helps remove excess iron from the brain and other organs, the heart, liver, spleen.

So, unlike other iron chelators that might be used pharmaceutically, it doesn’t have all these possible negative side effects, but it works very effectively. I mean, I’ve seen it be used in hereditary hemochromatosis patients to lower iron without blood removal … Now, people that have really high iron might need 3 grams a day, which can create diarrhea. So, you have to look at other potentially limiting factors.”

She also recommends taking curcumin with an iron-rich meal, such as shellfish or red meat, to inhibit iron uptake. Other supplements that help bind iron include silymarin (an extract from milk thistle). It is also very good for hemochromatosis patients because it lowers iron and helps protect and repair the liver. Another thing that binds to and lowers iron is alpha-lipoic acid. It’s also great for protecting nerves and lowering blood sugar.

“I don’t think silymarin lowers iron quite as much as curcumin, but it’s still a significant way to lower iron,” she says. “The best way to take these — to lower iron — is take them with iron-rich meals. If you want to take them just for medicinal properties but not to lower iron, take them away from iron-rich meals.”

Health Risks Associated with High Iron

The health risks of high iron are manifold and include an elevated risk of skin infections and skin cancer. I suspect high iron may actually be a catalyst when it comes to skin cancer, along with high linoleic acid (LA) intake. LA is oxidized by iron, creating something called lipofuscin, which is basically iron attached to oxidized LA.

A more common term for lipofuscin is liver spots. So, liver spots are a dermal representation of oxidative damage to LA by high iron. Similarly, skin cancer is likely driven by a combination of high LA and high iron. Ancestral LA levels were below 2%. Today, the average is around 25%. If you had normal ancestral levels, you could have higher iron yet not get as much damage.

Understanding Hemochromatosis

There are several potential diagnoses related to iron, including iron-deficient anemia, copper-deficient anemia, iron overload, and hereditary hemochromatosis, and getting to the correct diagnosis can be tricky.

“The nice thing is that you can always fall back on labs,” Sutton says. “You don’t want to just use symptoms to guide you, because if you’re using symptoms, then this person is well far down a pathological path that you could have potentially stopped years ago, if not decades before.”

Starting with hereditary hemochromatosis, this is when you have inherited one of three hemochromatosis genes, which causes increased iron absorption by decreasing hepcidin, a liver protein. If you have the hemochromatosis gene, you don’t make as much hepcidin, causing you to absorb more iron.

That can become pathological, because over time, you just keep absorbing more and more iron, until your body finally runs out of places to put it. The first place that gets overloaded is your liver. After that, your body will store the iron in other organs, such as your heart, pancreas, brain, pituitary gland, gonads, ovaries, testes, and skin.

Eventually, the iron will go everywhere because the human body has evolved to hold onto as much iron as possible. The only way, really, to lose iron is through blood loss. This is why menstruating women have a lower risk for high iron and a higher risk for low iron.

“Having said that, when you start looking at the hemochromatosis genes, all bets are off, because you’ll see females that have these hemochromatosis genes that develop high iron … you will even see children with the hemochromatosis genes that develop high iron,” Sutton says.

“I discovered that in my colleague’s 5-year-old, where predatory hemochromatosis was causing her to have severe neurological problems. That was a very difficult thing to get through because the hematologist didn’t really want to deal with it.

When you look at labs, hereditary hemochromatosis can look very similar to non-hereditary hemochromatosis, which is where you have high iron but you don’t have one of those hemochromatosis genes.

So, for you, you have more of a non-hereditary secondary hemochromatosis, because you have that thalassemia issue where your red blood cells are breaking and letting all this iron out and then you develop high iron with potentially low red blood cells.

That’s common with thalassemia. Some people, they don’t have a thalassemia gene and they develop high iron without hemochromatosis gene, because they’re just eating a lot of iron-rich foods and they’re not losing iron through menstruation. This is usually men.”

How to Diagnose Hemochromatosis

When it comes to lab work, Sutton recommends starting with a full iron panel, a complete blood count (CBC) test, gamma-glutamyl transferase (GGT), and a comprehensive metabolic panel to ensure you have sufficient liver enzymes. Measuring your copper and ceruloplasmin levels can also be helpful.

“The full iron panel has the ferritin, the TIBC [total iron-binding capacity], the UIBC [unsaturated iron-binding capacity], the serum iron and the iron saturation. With hereditary hemochromatosis, you develop high ferritin with a high iron saturation. That combination is hereditary hemochromatosis. So, over 45% iron saturation and high ferritin …

With hereditary hemochromatosis, you’ll see high iron, you’ll see the TIBC go low, the UIBC go low. The serum iron often goes high, and then that ferritin will go high. You’ll often see the liver enzymes go high and it’s common to see the red blood cells, hemoglobin, hematocrit go high.

But that doesn’t always happen. These days, so many are taking testosterone. So, you have to always ask, ‘Are you on testosterone?’ Because that can cause red blood cells, hemoglobin, hematocrit to go high as well …

I always get the GGT as a part of the labs that I order. Occasionally, I will see a high GGT when the AST and ALT, which are the other two liver enzymes, are normal. More often than not, I’ll see a high ALT or high AST. Usually, if they’re not drinking alcohol and they just have high iron, you’re going to see that high ALT.”

What’s the Ideal Ferritin Level?

Sutton recommends keeping ferritin below 100. Ferritin above 100 means you’re either inflamed, have high iron, or both. Studies referenced in her book suggest that anything over 200 is pathological. The higher your ferritin level, the shorter your lifespan. You’re also more likely to die of a heart attack and cancer.

Iron status does not follow a straight-line relationship with health. Instead, it follows a U-shaped curve, meaning both deficiency and overload increase risk. While iron-deficiency anemia impairs oxygen delivery and neurological development, iron excess drives oxidative stress, metabolic dysfunction and organ damage. The goal is not simply to avoid deficiency, but to stay within a narrow physiologic window.

Figure 1. U-Shaped Risk Curve for Iron Status. This illustration shows how health risk increases at both extremes of iron balance. Ferritin levels below approximately 25 ng/mL reflect iron deficiency, which raises risks for anemia, impaired cognitive development and infection susceptibility. The lowest overall risk appears in the middle range — roughly 60 to 75 ng/mL — where iron supports oxygen transport and mitochondrial energy production without generating excessive oxidative stress. Once ferritin rises above 100 to 150 ng/mL, cardiometabolic risk begins to increase. Levels above 300 ng/mL are associated with substantially higher risks of liver fibrosis, diabetes and other chronic diseases.

This U-shaped pattern explains why iron remains one of the most misunderstood nutrients in medicine. For decades, clinical practice focused almost exclusively on preventing deficiency. But modern data show that excess iron — particularly in men and postmenopausal women who lack a natural mechanism for iron removal — quietly accumulates over time.

Elevated ferritin and transferrin saturation signal biochemical overload long before symptoms appear. As described in precision-based iron research, maintaining ferritin within a moderate physiologic range helps avoid both oxygen deprivation at the low end and oxidative injury at the high end.

“I feel like 100 is high enough that I’m not swooping everybody in, but low enough that I’m not leaving stragglers out,” she says. “Now, if somebody has a ferritin over 100 with an iron saturation that is in the 40s or higher, then I’m highly suspicious of a hemochromatosis gene and I immediately want to get those hemochromatosis genes tested.

If they have a hemochromatosis gene, then we know why they’re high on iron and we know where this story is going — and it’s not going to be a pretty picture most likely. Then it’s time to refer to a hematologist … and talk to them about how to get iron lower …

The key is, if you don’t have a hemochromatosis gene, then you need to figure out ‘Why does this person have high iron? Do they have a thalassemia gene? Are they just eating a lot of iron?’ And then, ‘Do they have hemolysis for some unknown reason?’ That’s a non-hereditary hemochromatosis situation.

The treatment is basically the same, other than you want to use more of the supplements, go really heavy on the supplements to lower iron. If you have plenty of red blood cells and hemoglobin, then therapeutic phlebotomy is a wonderful place to start.

A lot of times people don’t because they either have a thalassemia issue where their red blood cells are getting chewed up too quickly, or they have lost so much blood so quickly because their doctors are just trying to get the iron down that they become low in hemoglobin or red blood cells. Rather than waiting for months for that to recover, you could be doing the supplements to lower the iron.”

The Link Between High Iron and Cushing’s Disease

Sutton’s husband also developed a pituitary tumor that was causing him to have high cortisol (Cushing’s disease). “Ultimately, I think the high iron created a lot of oxidative stress on his pituitary gland,” Sutton says. The only reason he was diagnosed early enough to save him was that they’d been checking his cortisol and DHEA on a regular basis.

“Periodically, they would jump up and then go back down. Then when the hemochromatosis got properly treated and the DHEA was still high, we were like, ‘Why is this happening?’ So we went to the endocrinologist and I said, ‘I’m worried my husband has Cushing’s.’ She was like, ‘He doesn’t have Cushing’s. He doesn’t look like somebody with Cushing’s. His hemoglobin A1C is normal.’

Five months later, he’s having surgery to remove the pituitary tumor. The reason I say that is because for years, he was told, ‘You just need to exercise and lose weight.’ His problem was not exercise. He had a pituitary tumor and hemochromatosis. Hemochromatosis was destroying his liver and his brain and his heart and everything else, and the pituitary tumor was causing him to have high cortisol, which made him look overweight.”

I believe progesterone may be one of the best ways to treat Cushing’s disease, as it very effectively blocks cortisol. Other natural substances that will inhibit cortisol include aspirin, DHEA, pregnenolone, emodin, vitamins A and D, gelatin or glycine, and niacinamide.1

The normal dose for progesterone is 25 to 50 milligrams. For Cushing’s, I would recommend about 300 mg. It’s virtually impossible to overdose on progesterone and there are no downsides to it. One caveat is that you need to administer it correctly to gain the optimal effects.

Avoid creams, pills and suppositories. Instead, mix pharmaceutical grade progesterone with the contents of one natural vitamin E capsule. Mix it with a paperclip or tiny spoon until all the powder is dissolved, then rub it on your gums. Vitamin E is the only natural compound that dissolves progesterone completely. For guidance on how to pick a good vitamin E supplement, see “The Four Hormones Most Adults Need More Of.”

Understanding Iron-Deficient Anemia

As explained by Sutton, iron-deficient anemia is a serious issue. Children born of women with iron-deficient anemia have significantly higher risk of low IQ, ADD, ADHD, and other neurological issues that often do not go away with age.

“Many kids suffer from low iron, because they eat a lot of calcium rich foods. Calcium binds to iron, and then you get low in the iron. Maybe they’re picky eaters, they’re growing rapidly. So many kids are not being checked for their iron levels and they’re being diagnosed with ADHD when their problem is actually just low iron, because if you don’t have enough iron, you can’t make dopamine. So, low iron is a serious issue.”

People with iron-deficient anemia will typically have high TIBC and UIBC, as their bodies are trying to mobilize more iron. Serum iron and iron saturation will be low and ferritin will typically be below 30.

“Now, iron-deficient anemia is more complicated in many ways because the question is, why are you low in iron?” Sutton says. “There’s so many reasons that you can be low in iron. Are you just not eating enough? Are you not absorbing it? I think the most common reasons that people develop low iron is because they have a GI bleed. They have intestinal malabsorption issues, maybe undiagnosed celiac disease.

There is a gene that can cause you to be more likely to have low iron. I have that gene and that gene actually causes you to make more hepcidin. With iron-deficient anemia you’ll also see low red blood cells sometimes, low hemoglobin, and low hematocrit. MCH [mean corpuscular hemoglobin] might get low, MCV [mean corpuscular volume] might get low.”

Copper Deficiency Can Cause Both Low and High Iron

One common cause for iron-deficient anemia is a deficiency in copper. Paradoxically, lack of copper is also a common cause for iron overload. Sutton explains:

“The reason for that is because copper is necessary for two key enzymes. The first one is called hephaestin and the second one is called ceruloplasmin. Hephaestin is in the lining of the gut, the intestinal lining. Copper is necessary for iron to be absorbed in the gut lining. So, without copper, you will not absorb iron and you will develop iron-deficient anemia.

Once iron has been absorbed in the gut lining by hephaestin, it passes it off to ceruloplasmin, which is the second copper-rich enzyme. Ceruloplasmin basically then allows that copper to transfer in and then move throughout the body. So, without ceruloplasmin, iron gets stuck in the tissues. It’ll get stuck in the digestive system, it’ll get stuck in the retina, it’ll get stuck in the brain, it’ll get stuck in the liver.

So, you develop iron overload in the tissues. But eventually, if you’re low in copper long enough, you might then become low in iron, and then you don’t end up with all this extra iron in the tissues. The solution is take copper to fix that problem. That’s the way you solve copper-deficient anemia.

Copper-deficient anemia looks very similar to iron-deficient anemia if you’re looking at the iron panel. You’ll have a high TIBC, high UIBC, low serum iron, low iron saturation, low ferritin. You’ll also potentially see low neutrophils and low white blood cells, because you need copper to have normal immune function as well. So, you might be more at risk for infections.

Then of course you can look at the ceruloplasmin. I don’t find ceruloplasmin to be the easiest lab to look at, because it’s an inflammatory marker … If you’re taking hormones like estrogen or birth control or you’re pregnant or you’re just inflamed or have an infection, ceruloplasmin can jump around and go high.

If you have a low or low-normal ceruloplasmin, and then you take copper and ceruloplasmin goes up, that’s a good sign that you didn’t have enough copper.”

How to Get More Iron Into Your Diet

The best way to get iron is through your diet. Shellfish and beef are iron-rich foods with highly absorbable iron. That’s key, because there are two types of iron — heme iron and non-heme iron, the latter of which is not very absorbable. Heme iron is found in animal products while non-heme iron is found in vegetables such as spinach.

“If you’re not eating iron-rich foods like red meat, then you’re more likely to get low in iron if that is something that you struggle with,” Sutton says. “If you struggle with being high in iron, maybe you don’t want to eat as many of those things or maybe you just want to remove blood and supplement accordingly, so that you continue to eat those things.

The form that I like if I’m going to go to a supplement is ferrous peptonate, which I found to be the gentlest on my gut but also get the iron levels up. I really don’t like ferrous sulfate, which is the most common given iron. I don’t think it works very well, and it tends to create a lot of stomach pain. I always have to take my iron with food and sometimes I’ll add copper or vitamin C to it. If I don’t take it with food, it’s really going to upset my stomach.”

More Information

To learn more, check out Sutton’s books, “Genetic Testing: Defining Your Path to a Personalized Health Plan: An Integrative Approach to Optimize Health,” and “The Iron Curse: Is Your Doctor Letting High Iron Destroy Your Health?”

In the past, I’ve written about the benefits of near-infrared (NIR) light and its role in activating photobiomodulation, which is a therapy wherein exposure to specific light wavelengths stimulate beneficial processes in your tissues. For example, it can promote collagen production,1 which can help rejuvenate skin health. Moreover, it has anti-inflammatory and wound-healing properties, making it useful for faster tissue repair and recovery from injuries.2 But that’s not all NIR light can offer.

Recently, I’ve been doing a deep dive into the published literature involving NIR light, mitochondrial melatonin, and its related biological processes. In my paper, “Optimizing Brain Biology Through Near-Infrared-Induced Mitochondrial Melatonin Synthesis,” now published in the journal Cureus, I examine how NIR can be used to activate mitochondrial melatonin synthesis to create an antioxidant cascade that offers neuroprotective benefits. You can view the published study below.

> > > > > Click Here

A New Series of Health Insights Is on the Way

VIKTIG

A New Series of Health Insights Is on the Way
Our team has been working behind the scenes to prepare new research and practical health strategies for our readers. While we finish preparing what’s coming next, we invite you to explore one of the most-read articles from our library below. See exactly what’s changing →

It’s common to be perfectly hydrated and still get hit with a brutal headache right after a workout. For some, it starts as a subtle throb on both sides of the head. For others, it’s a sudden pounding that stops them in their tracks. These are known as exercise-induced headaches, which some describe as “the worst headache of my life.” They affect up to 26% of adults, depending on the study.1

While exercise headaches don’t always mean something is seriously wrong, they’re also not something to brush off. When your brain sends up a signal like that, it’s worth listening. What’s frustrating is how unpredictable they often feel. You drink water, fuel properly, get enough sleep and still end up sidelined by pain. So, what’s actually going on?

The answer has less to do with how hydrated you are and more to do with how your body regulates pressure and blood flow under stress. You don’t need to give up your workouts to stop the cycle. You just need to understand what’s driving these headaches in the first place. That’s where the science comes in.

Exercise Headaches Happen When Your Brain Gets Too Hot

An article in The Conversation explored why some people develop exertion headaches despite staying hydrated and exercising regularly.2 It examined current theories and findings to help explain what’s actually going on inside your body when these headaches strike.

• Exercise headaches affect people differently based on how fit they are — These headaches are more common in people new to intense workouts or those who ramp up too fast. They usually happen after a physically demanding session. But what’s considered “strenuous” really depends on your current fitness level, so even moderate effort could trigger them if you’re not yet adapted.

• The pain lasts from a few minutes to two full days — However, they sometimes go away in time. The article notes that some people stop getting these headaches after a few months of consistent training. That’s because your cardiovascular system slowly becomes better at handling physical stress and regulating blood flow to your brain.

• A key cause appears to be how your brain handles heat — Unlike the rest of your body, your brain doesn’t sweat. To cool down, it redirects more blood flow to your head during exercise. This creates higher pressure in your skull, which triggers pain.

Further, during exercise, your arteries and veins widen to deliver more blood and oxygen to your muscles and organs. The same thing happens in your brain, but in a confined space, this creates extra pressure, especially when you’re already hot or dehydrated. When it’s hot outside, your body sends even more blood to your brain in an attempt to cool it down. This overcompensation results in increased intracranial pressure and worsens the headache.

• Dehydration compounds the problem, but isn’t always the main trigger — While many people assume they’re getting these headaches from not drinking enough water, hydration alone isn’t the whole story. However, dehydration puts extra stress on your cardiovascular system, which could make your brain’s cooling response more aggressive — and more painful.

• Gradual fitness improvements reduce headache risk over time — People who build up slowly tend to report fewer and milder exercise headaches, likely because their blood vessels become more efficient at dilating and contracting with less pressure buildup.

Vision Problems and Nausea Are Red Flags You Shouldn’t Ignore

Although most exercise headaches are harmless, some are tied to dangerous conditions like brain hemorrhages, infections, or elevated brain pressure.3 If you’re experiencing these headaches for the first time, or if they’re sudden and severe, you should get evaluated. The Cleveland Clinic also broke down how exertion headaches differ from typical head pain.4

• Some symptoms mimic migraines and need to be taken seriously — While throbbing pain on both sides of the head is common, the Cleveland Clinic highlights more serious symptoms like vision changes, nausea and vomiting. If you’re seeing blind spots, getting dizzy or feeling sick to your stomach after workouts, that’s not something to push through.

• Unlike general tension headaches, exertion headaches often feel like a strong pulsing sensation — This typically builds quickly during or after physical activity. They also sometimes feel like a thunderclap — sudden and explosive. These details matter because understanding your symptoms helps you communicate more clearly with your doctor if you need to seek help. Underlying conditions are rare but important to rule out.

• If you’ve never had one before, don’t brush it off — First-time exertion headaches, especially if severe or paired with other neurological symptoms, should be evaluated by a medical professional. Confusion, fainting, extreme drowsiness or a headache that lasts more than two days are all red flags.

Once you understand what’s triggering your symptoms and get the green light from your doctor, you’ll be more confident about pushing forward with your workouts without worrying about the next headache hitting out of nowhere.

Why Pushing Too Hard Too Soon Sets You Up for Headaches

According to Dr. Ashhar Ali, a neurologist at Henry Ford Health, starting a workout program too aggressively runs the risk of causing your brain and body to react negatively.5 If your system isn’t yet conditioned for exertion, the added pressure from overexertion could show up as a headache. The fix is simple but requires patience: start slow and give your body time to adapt.

• Dehydration is a major driver of head pain — While it’s possible to get an exercise headache even if you drink plenty of water, Ali emphasizes the systemic impact of dehydration on your brain. It doesn’t just leave you tired, it alters fluid balance, increases body strain and heightens the chances of blood vessel dilation in your head, triggering that pounding sensation. “Headaches are another side effect of not drinking enough water,” he warns.6

• Heat overload during workouts makes things worse — Exercising in hot environments, whether outdoors in direct sun or indoors with poor airflow, is another trigger. What’s more, your clothing choice matters. Heavy fabrics, dark colors, or non-breathable materials trap heat and force your body to work harder to cool down. That extra burden increases pressure in the brain, leading to pain.

• Altitude training isn’t for everyone, and it’s a problem if you’re not used to it — Working out at higher elevations, especially while traveling, is a serious headache trigger. The oxygen is thinner at higher altitudes, and your brain has to work harder to compensate.

For people not acclimated to these conditions, the change in oxygen pressure often results in sharp, exertion-related headaches. Ideally, take a few days to adjust before attempting intense exercise in these conditions.

• These headaches are often mistaken for something else — People frequently misattribute these headaches to stress or muscle tension, when in fact, it’s the training environment and pace that’s to blame. This misdirection leads many to overlook simple fixes like resting, hydrating, staying cool, or adjusting their workout intensity.

How to Stop Headaches from Derailing Your Workouts

If you’re dealing with headaches after a strength-training session, or even just an intense walk, it’s not in your head, at least not the way you think. The problem isn’t always hydration or a poor night’s sleep. Often, it’s how your brain responds to overheating, overexertion or sudden pressure changes.

The good news? You don’t have to live with it, and you don’t have to quit your workouts either. These are direct ways to fix the root of the issue and keep your head clear while you train. Here’s what I recommend if you’re trying to avoid exercise-induced headaches:

1. Start with a slow warm-up and build intensity over time — You wouldn’t go from zero to sprint in five seconds, and your brain doesn’t like it either. Give your blood vessels time to adapt by easing into your workout. Start with gentle movements, low weights, or a light walk. If you’ve been sedentary or are just getting back into fitness, your body needs time to relearn how to regulate pressure and blood flow.

2. Fix your hydration before, during and after training — If you’re even slightly dehydrated, your body has to work harder to pump blood, especially to your brain. That raises your risk for pain. Don’t just sip water once your headache starts, get ahead of it. Drink throughout the day, not just right before or during your session.

If you sweat a lot or train outside, you’ll want to consider a mineral-rich hydration option like coconut water or a homemade mix of water, sea salt, and fruit juice to replenish what you lose. Overall, just listen to your thirst. A good rule of thumb is to check your urine. It should be a pale yellow color — if it’s dark, you’re dehydrated.

3. Control your workout environment — If you’re exercising in a hot, stuffy room or wearing heavy or dark-colored clothes, you’re setting yourself up for overheating. Switch to natural breathable fabrics and avoid workouts in extreme heat. If you’re indoors, use a fan or open a window. Your brain doesn’t cool itself like your skin, so anything that prevents heat buildup helps protect you.

4. Adjust your workouts at high altitude or during travel — If you’re in the mountains or somewhere with thinner air, your brain is working overtime just to get enough oxygen. It’s easy to push too hard without realizing it. If you’re not used to high elevations, avoid intense training the first few days. Focus on lower-impact options like walking, yoga or light bodyweight exercises while your body adjusts.

FAQs About Exercise Headaches

Q: Why do I get a headache after working out, even when I drink water?
A: Exercise headaches aren’t always caused by dehydration alone. Your brain can’t cool down by sweating like the rest of your body, so it sends more blood to your head to regulate temperature. That increases pressure inside your skull, which triggers pain, especially if you ramp up intensity too fast.

Q: Are exercise-induced headaches dangerous?
A: Most of the time, no. They usually fade within a few hours to two days and tend to improve over time as your cardiovascular system adapts. However, if it’s your first headache, or if the pain is sudden and severe, lasts longer than two days or comes with symptoms like nausea, vision changes, or confusion, you should get checked to rule out more serious conditions.

Q: Who is most likely to get these headaches?
A: People who are new to intense workouts, pushing too hard too fast, training in high heat or altitude, or wearing heat-trapping clothes are more likely to experience exercise headaches. Dehydration and poor conditioning are also major contributors.

Q: How do I stop these headaches from happening again?
A: Start with a slow warm-up, stay hydrated throughout the day, train in a cool environment and avoid high-intensity workouts in extreme heat or thin air.

Q: What symptoms should I look out for?
A: Red flags include a thunderclap headache (sudden and extreme pain), fainting, stiff neck, confusion, vomiting or vision issues. If any of these show up, or if the headache lasts more than 48 hours, it’s important to get evaluated for more serious conditions like vascular spasms or brain bleeds.

Benign prostatic hyperplasia (BPH), commonly known as enlarged prostate, affects millions of aging men and steadily interferes with everyday life. This condition means the prostate gland enlarges and presses against the urethra, the tube that carries urine out of your body. Once that narrowing begins, urination becomes difficult.

Common symptoms include frequent urination, urgency, waking repeatedly at night to urinate, weak urine flow, and a persistent feeling that your bladder never fully empties. When left untreated, the pressure can damage your bladder, increase infection risk, and strain your kidneys. Researchers have long known that inflammation, obesity, and metabolic syndrome contribute to prostate tissue growth.

But a key question remained — do the foods you eat every day actually drive that inflammatory process enough to change your prostate? A recent study combined population data, genetic analysis, and animal experiments to find out, and the results point clearly toward your plate as a major factor in whether your prostate stays healthy or begins to enlarge.1

Inflammatory Diets Are Linked to Prostate Enlargement

A study published in the journal Frontiers in Nutrition examined whether diets that promote inflammation increase the risk of an enlarged prostate.2 The researchers analyzed health data from a large U.S. survey called the National Health and Nutrition Examination Survey (NHANES), studied genetic data, and ran laboratory experiments in rats to see how different diets affect prostate tissue.

The results showed a clear pattern: men with higher scores — meaning more inflammatory diets — had a greater chance of having an enlarged prostate. Even after researchers accounted for factors such as age, body weight, smoking, alcohol use, and metabolic disease, the link stayed strong. In fact, every one-point increase in the inflammatory diet score was associated with approximately 7% higher BPH risk.

• Risk increased steadily as diets became more inflammatory — As dietary inflammation increased, the likelihood of prostate enlargement also increased. This dose-response pattern suggests the body may respond gradually to dietary inflammation rather than reaching a sudden tipping point.
The analysis showed that genetic markers associated with healthier dietary patterns were linked to a lower risk of BPH. Overall, these results indicated that healthier diets were associated with about a 20% lower risk of prostate enlargement.
Researchers also looked at whether factors like age, income, smoking, or health conditions changed the relationship between diet and prostate enlargement. The connection stayed similar across most groups. For example:

◦ Men with and without metabolic syndrome showed the same diet-related risk pattern.
◦ Smokers and nonsmokers both showed higher BPH risk with inflammatory diets.
◦ Men with heart disease or high blood pressure still showed the same trend. This suggests that inflammatory diets affect prostate health broadly rather than only affecting certain types of people.

• Animal experiments confirmed that diet changes the prostate — The researchers then tested the idea in a laboratory using rats. The animals were fed different diets for 12 weeks:

◦ A normal, balanced diet
◦ A pro-inflammatory diet high in fat and sugar
◦ An anti-inflammatory diet designed to reduce inflammation

Rats eating the inflammatory diet developed noticeably larger prostates than those eating the other diets. Blood tests also showed that rats on inflammatory diets had much higher levels of inflammatory chemicals called cytokines. These included substances the immune system releases during inflammation.
Higher levels of these signals appeared both in the blood and inside prostate tissue. Researchers also saw increased levels of a marker that indicates rapid cell growth. When this marker rises in the prostate, it means the cells in the gland are multiplying faster than normal.

• Inflammatory diets changed the structure of the prostate — When researchers looked at the prostate tissue under a microscope, they saw clear physical changes in the animals eating inflammatory diets. The prostate glands showed abnormal layers of growing cells and distorted gland structures.

The tissue also contained excess collagen, which indicates thickening and scarring caused by chronic inflammation. Collagen is normally a healthy structural protein, but when too much accumulates inside organs, it forms stiff scar tissue that thickens and enlarges the gland. In contrast, rats eating the anti-inflammatory diet kept a normal prostate structure with very little tissue thickening.

• Inflammatory diets set off a chain reaction inside the body — The researchers noted that inflammatory diets are associated with increased oxidative stress — a buildup of harmful molecules called reactive oxygen species (ROS).

In animal models, these molecules were found to activate inflammatory pathways linked to growth signals in prostate tissue. This process appears to encourage fibroblasts — cells that produce connective tissue — to produce excess collagen, which has been linked to thickening and enlargement of the prostate.

Fibroblasts are repair cells that produce collagen, the structural protein in connective tissue. Normally, they help maintain healthy organs, but chronic inflammation may put them into overdrive, contributing to collagen accumulation linked to prostate stiffening.

• Changes in gut bacteria also play a role — The study also showed that inflammatory diets affect the gut microbiome — the community of bacteria living in your digestive system. Diets that promote inflammation were associated with lower levels of beneficial bacteria and higher levels of bacteria linked to disease.

These shifts weaken the intestinal barrier — sometimes called “leaky gut” — allowing bacterial toxins to slip into your bloodstream and trigger immune reactions far from your digestive tract. Once these toxins circulate through your body, they trigger inflammatory signals in many organs, including the prostate. This gut-driven inflammation forms a link between diet, whole-body inflammation, and prostate enlargement.

Note that these findings include data from laboratory or animal research and may not directly apply to human health.

Reduce Dietary Inflammation to Protect Your Prostate

Prostate enlargement doesn’t appear overnight. It grows out of years of chronic inflammation, metabolic stress, and dietary patterns that constantly trigger immune signals inside your body. Inflammatory diets may contribute to prostate tissue growth, collagen buildup, and immune activation. When that cycle continues long enough, the prostate may expand and begin to press against the urethra.

That means the most powerful strategy focuses on removing the triggers that keep inflammation active. Lowering dietary inflammation, improving metabolic health, and supporting cellular energy production may help reduce conditions associated with prostate tissue overgrowth. If you already struggle with urinary symptoms, these steps help reduce the biological pressure driving that enlargement.

1. Remove inflammatory foods that drive chronic immune activation — Your first move involves removing the foods that push your body into an inflammatory state.
Highly processed foods, seed oils, ultraprocessed snacks, and restaurant foods cooked in vegetable oils deliver large amounts of linoleic acid (LA), a polyunsaturated fat that disrupts mitochondrial energy production when consumed in excess. These fats accumulate in your tissues and trigger inflammatory signaling throughout your body.
Replace seed oils, including canola, corn, soybean, safflower, sunflower, and grapeseed oils, with stable fats such as grass fed butter, ghee, and tallow. If you frequently eat packaged snacks, granola bars, vegetable chips, or premade frozen meals, begin eliminating them because those products almost always contain inflammatory seed oils that worsen metabolic stress.

2. Increase carbohydrate intake to restore cellular energy production — Your cells rely on carbohydrates to generate energy efficiently. When carbohydrate intake stays too low for long periods, your body enters reductive stress, a state where mitochondrial energy production slows — like an engine starved of the right octane — and inflammatory signaling increases.
Most adults perform best with 250 grams of carbohydrates per day, though highly active individuals often need more. Start with easily digested carbs like fruit and white rice, especially if your gut health is compromised. Then, gradually add in root vegetables, non-starchy vegetables, starchy vegetables like squash or sweet potatoes, beans and legumes, and finally minimally processed whole grains — only if your gut can handle them.

3. Support a healthy gut microbiome to reduce inflammatory toxins — The research highlighted a powerful connection between the gut and the prostate. When your microbiome becomes imbalanced, harmful bacteria release endotoxins — toxic fragments from bacterial cell walls — that leak into circulation and trigger immune responses throughout your body, including inside the prostate. Improving gut health reduces those inflammatory signals.
Begin by prioritizing whole foods, gradually increasing fiber as your digestive system tolerates it, and avoiding ultraprocessed foods that damage your microbiome. Seed oils and ultraprocessed foods disrupt the thin protective layer inside your gut and increase oxidative stress. Your gut lining is made of tightly connected cells that act like a security wall.
When those connections loosen, bacterial toxins slip into your bloodstream and trigger inflammation throughout your body. Focus on giving your intestinal cells the energy they need to repair themselves by consuming easily digested carbohydrates. These foods provide glucose, which supports mitochondrial energy production inside gut cells and helps maintain the barrier that keeps harmful substances out of circulation.
Finally, support the bacteria that help maintain that barrier. Certain beneficial microbes produce compounds called short-chain fatty acids, including butyrate. Butyrate serves as the main fuel for the cells lining your colon and helps tighten the junctions between them.
As your digestion improves, slowly introducing small amounts of tolerable fiber encourages these bacteria to produce butyrate. That process may help strengthen your gut lining from the inside and reduce the inflammatory signals linked to prostate enlargement.

4. Build metabolic strength with daily movement and muscle maintenance — Your metabolic health strongly influences inflammation and prostate disease risk. Regular movement improves mitochondrial function, increases insulin sensitivity, and supports energy production throughout the body.
Work your way up to one-hour daily walks and two resistance sessions per week to preserve muscle mass. Muscle is your body’s largest metabolic organ — it pulls glucose out of your bloodstream, stabilizes blood sugar, and helps keep inflammatory signaling in check. If you spend long hours sitting during the day, break that pattern by standing, stretching, and walking regularly.

5. Prioritize high-quality protein and collagen to stabilize metabolism — Your body relies on adequate protein intake to maintain muscle mass, regulate metabolism, and support tissue repair. Protein deficiency weakens metabolic resilience and worsens inflammatory signaling throughout the body.
Aim for 0.6 to 0.8 grams of protein per pound of ideal body weight (approximately 1.32 to 1.76 grams per kilogram) — and make one-third from collagen-rich sources like bone broth, slow-cooked meats with connective tissue, or a quality collagen supplement.
Unlike the excess collagen that inflammation forces into prostate tissue — causing stiffness and swelling — the collagen you eat is broken down into amino acids that your body uses to maintain healthy connective tissue wherever it’s needed, without selectively building up in any one organ. This balance supports connective tissue health and helps maintain the metabolic stability that keeps inflammatory pathways under control.

FAQs About Prostate Enlargement and Inflammatory Diet

Q: What is BPH?
A: BPH is a noncancerous enlargement of the prostate gland. The prostate surrounds the urethra, the tube that carries urine out of your body. When the gland grows larger, it presses on the urethra and makes urination difficult. Common symptoms include frequent urination, weak urine flow, urgency, and waking at night to urinate.

Q: How does diet affect prostate enlargement?
A: Research suggests diets that promote inflammation are linked to an increased risk of prostate enlargement. Scientists measure this using the Dietary Inflammatory Index, which scores how strongly individual foods are associated with inflammatory markers in the body. Higher scores — meaning more inflammatory diets — are linked to greater risk of BPH.

Q: What did the study find about inflammatory diets and prostate health?
A: Researchers found that every increase in the inflammatory diet score was associated with a higher risk of prostate enlargement. Men who consumed more inflammatory foods had significantly higher odds of developing BPH. The relationship followed a steady pattern, meaning the risk increased as the diet became more inflammatory.

Q: What happens inside the body when diets trigger inflammation?
A: Inflammatory diets are associated with elevated immune signals and oxidative stress. In animal studies, these changes were linked to increased cell growth, excess collagen buildup, and tissue thickening inside the prostate. Over time, these processes may cause the gland to enlarge and interfere with normal urination.

Q: What lifestyle changes help lower the risk of prostate enlargement?
A: Helpful strategies focus on reducing chronic inflammation and improving metabolic health. This includes removing processed foods and seed oils, eating enough carbohydrates from whole foods such as fruit and cooked white rice, supporting gut health, and staying physically active to improve cellular energy production. These steps help reduce the inflammatory signals associated with prostate growth.

This article is for informational purposes only and does not constitute medical advice. Consult a qualified healthcare provider before making changes to your health regimen.

Test Your Knowledge with Today’s Quiz!
Take today’s quiz to see how much you’ve learned from yesterday’s Mercola.com article.

At what age did women in the study show increased risk factors of liver fibrosis?

Early 30s
Late 30s
Late 40s
The average age was in the late 40s, and women showed a sharper rise in liver fibrosis risk when metabolic issues were present at this stage. Learn more.
Early 60s

A New Series of Health Insights Is on the Way

VIKTIG

A New Series of Health Insights Is on the Way
Our team has been working behind the scenes to prepare new research and practical health strategies for our readers. While we finish preparing what’s coming next, we invite you to explore one of the most-read articles from our library below. See exactly what’s changing →

Proteins work around the clock to keep your body running. These vital molecules handle the building and repair of your tissues, from your muscles to your organs. They also play an essential role in keeping your enzymes, hormones, and immune system functioning as they should. They’re made up of smaller components called amino acids, and your body can’t manufacture all of them.1

The ones you can’t produce, known as essential amino acids, need to come from what you eat, which is why consuming a range of protein-rich foods like meat, eggs, and dairy products matters. However, getting the most from this macronutrient goes beyond just choosing the right foods and meeting your daily intake. The best time to eat protein is another factor worth considering.2

Is Morning the Best Time to Eat Protein?

Let’s make one thing clear — your body benefits most when protein is spread evenly throughout the day, not packed into a single meal. Still, certain times offer unique advantages because of how your body processes and uses nutrients.

Breakfast is a prime example. It’s often the meal with the least protein, even though it’s your first opportunity to replenish amino acids after an overnight fast. Starting the day with enough protein helps rebuild that supply and sets the pace for steady metabolism and balanced hormone activity in the hours ahead.

• Protein has a unique thermic effect — This is the amount of energy your body spends digesting and processing food. Of all macronutrients, it requires the most energy to metabolize.3 Eating protein early in the day takes advantage of that effect, creating a small but meaningful rise in calorie expenditure and contributing to a healthier metabolic function.

• Morning protein also helps regulate hunger hormones — Research shows that ghrelin, the hormone that signals hunger, drops more sharply after a high-protein breakfast. Meanwhile, hormones like peptide YY and GLP-1, which promote satiety, rise significantly. This combination helps you feel full for longer stretches, reducing the urge to snack before lunch.4,5

• Clinical research supports these effects — In one study involving obese Chinese adolescents, replacing a grain-based breakfast with an egg-based meal led to a greater reduction in body weight after three months. According to the authors, this effect occurs “possibly through its regulation of satiety, subsequent food intake, and appetite hormones.”6

Another trial compared an egg breakfast to a bagel breakfast with the same calorie content among adults following a weight-loss program. After eight weeks, the egg group showed a 61% greater drop in body mass index (BMI), 65% more weight loss overall, and a 34% larger reduction in waist circumference. The only difference was that one meal provided higher amounts of morning protein.7

These findings make a strong case for eating protein at breakfast. A nourishing morning plate might include low-LA eggs cooked in butter or ghee, paired with fruit and a small serving of cheese made from A2 milk. If you enjoy something warm and comforting, bone broth with sourdough toast and scrambled eggs are good options.

Do I Really Need Protein Right After a Workout?

Physical training deliberately challenges your muscles, creating microscopic damage that signals them to adapt and grow stronger. Every workout, whether it emphasizes strength, stamina, or flexibility, produces this controlled stress. Your body then relies on protein afterward to supply the amino acids needed to rebuild and reinforce those fibers.8

• Muscle protein synthesis drives repair and growth — After exercise, your body activates muscle protein synthesis, the process that rebuilds and strengthens fibers. This process depends on an adequate supply of amino acids, and the hours immediately after training are when your muscles use them most efficiently. This period is often called the post-exercise anabolic window, when your muscles are more sensitive to protein intake and more responsive to rebuilding signals.

• Protein intake during the anabolic window improves recovery — Research published in Nutrients9 recommends consuming around 0.3 to 0.4 grams of protein per kilogram of body weight within two hours of finishing exercise. For most adults, this translates to 20 to 40 grams per meal, depending on body size. Older adults, who experience reduced anabolic sensitivity, tend to benefit from the higher end of this range.

• Leucine triggers the anabolic response — Among amino acids, leucine plays the key role in switching on muscle-building pathways. A post-workout meal that provides 2 to 3 grams of leucine is generally enough to maximize this response.

Animal proteins, especially whey, beef, poultry, and eggs, contain enough leucine per serving to meet this threshold. In contrast, plant proteins usually contain lower levels of leucine and may need to be consumed in higher quantities to match the same anabolic response.

• Animal protein outperforms plant protein for post-exercise recovery — A controlled trial at Texas A&M University10 tested how protein type influences recovery. Participants completed high-intensity military-style exercises and were given either pork-based or plant-based meals ready-to-eat (MRE) with equal protein content.

Those who ate the animal-based meals experienced less soreness, lower inflammation, and healthier hormone balance afterward. Researchers attributed this to the higher amino acid density and the presence of creatine in animal protein, both of which support energy production and muscle repair.

• Protein timing matters, but precision isn’t everything — The anabolic window doesn’t require eating immediately after training. It simply means your body is especially receptive to protein for about two hours post-exercise. Eating within this period helps maximize repair and growth, ensuring your workout yields the greatest return.

Learn more about the benefits of post-workout protein intake in “Eating Animal Protein After Training Improves Recovery, According to Study.”

Is It Good to Eat Protein Before Bed?

Your body doesn’t stop repairing and rebuilding when you go to sleep. In fact, many of the tissue repair processes initiated during the day begin to take place more actively overnight. Protein intake before bedtime supports this repair phase by supplying amino acids to the bloodstream during sleep, when no additional food is being consumed.11,12

• Overnight fasting limits amino acid availability — The hours between dinner and breakfast create a long fasting window. Without a late protein source, the body may run low on circulating amino acids, tipping muscle balance toward breakdown rather than repair. Pre-sleep protein intake offsets this by maintaining a positive protein balance throughout the night, keeping muscle protein synthesis active.

• Casein supports sustained amino acid release — Casein, a milk-derived protein, digests more slowly than other sources and provides a steady amino acid supply for several hours. Studies show that consuming 30 to 40 grams of casein before sleep increases overnight muscle protein synthesis, especially if you’ve exercised earlier in the day and your body is still in a state of heightened repair.

For older adults, this approach is especially helpful. As you age, your muscles become less responsive to the normal signals that trigger protein synthesis, a process known as anabolic resistance. Providing a steady flow of amino acids during sleep helps overcome that reduced sensitivity.

• Whole-food sources offer practical options — While casein powders are often used in studies, whole foods provide an equally effective, nutrient-rich alternative. Greek yogurt or cottage cheese delivers both casein and additional micronutrients that support muscle and metabolic health. They are easy to digest and fit into most evening routines.

Remember that pre-sleep protein intake doesn’t replace the importance of total daily intake, but it provides a practical way to extend support into the overnight hours when your body’s needs continue.

How Much Protein Do You Need to Eat Daily?

Your daily protein needs aren’t defined by your current weight alone. Instead, you need to calculate it based on your ideal body weight — the weight most appropriate for your height, gender, and age. This distinction matters because using current weight, especially if you’re overweight or underweight, can lead to misleading protein targets that either overshoot or underserve your actual physiological needs.

• Determining the right amount of protein for your body — As a rule, protein should make up about 15% of your daily calories. More specifically, most adults need about 0.8 grams of protein per pound of ideal body weight, or about 1.76 grams per kilogram for those using metric measurements.

Approximately one-third of this protein, or about 5% of your daily protein total, should be collagen. Some good sources include bone broth and connective tissue-rich cuts like oxtail and shank.

• How to get your ideal bodyweight — First, you need to figure out your ideal weight. There are several ideal body weight calculators online that are easy to use. Just plug in your age, gender, and height and the calculator will give you a range based on commonly used formulas.

Multiply your ideal weight by 0.8 to get your daily goal. For example, if you weigh 160 pounds but your ideal weight is 128 pounds (the equivalent of having 20% body fat), you’d multiply 128 by 0.8, giving you a daily protein target of 102.4 grams. This same principle applies across ages and body types, including seniors, who benefit from the higher end of the range due to reduced anabolic sensitivity.

• Distribute protein evenly across meals — Meeting your target is easier when intake is spread out. If you eat three meals a day and need about 100 grams, aim for roughly 33 grams per meal. Someone whose ideal weight is 135 pounds would need about 108 grams total. That’s around 54 grams per meal if eating twice daily. For reference, each ounce of steak provides about 7 grams of high-quality protein, so a 5-ounce portion delivers about 35 grams.

• Protein needs vary with age and activity — Children generally need 5 to 10 grams per meal, while young adults maintain balance with about 20 grams. Most normal-weight adults require at least 30 grams per meal to build muscles effectively. Those who are older, more active, or recovering from illness may need more. Your personal sweet spot depends on your metabolic health, training intensity, and recovery demands.

• Does total protein matter more than timing? While both factors play a role, total intake carries more weight. Timing simply enhances how efficiently protein is used. Even when you distribute it well across meals, your body can’t perform optimally if your overall intake falls short. But once your total need is met, spreading it evenly throughout the day supports steadier amino acid availability.

• Balance your intake; more isn’t always better — Protein is vital, but consistently eating far beyond your needs can create strain on your metabolism, liver, and kidneys.13 It can also lead to amino acid imbalances if collagen sources are neglected. Staying close to your calculated range and maintaining a mix of lean and collagen-rich proteins ensures that your intake supports long-term health rather than overtaxing your system.

Rich Protein Sources to Add to Your Meals

Protein doesn’t have to be complicated or time-consuming to add to your diet. Whether you’re cooking from scratch, assembling leftovers, or reaching for something quick, there are plenty of nutrient-dense options that make it easy to hit your daily target.

• Animal-based proteins — Animal proteins provide the full spectrum of amino acids in the ratios your body can use immediately. They’re the most efficient way to meet your daily target, meal by meal. Some good sources include lean, grass fed beef, organic, pastured eggs, wild-caught fish, and grass fed dairy.

• Plant-based protein — Soy is often promoted as a healthy protein source, but unfermented soy products are linked to a range of health concerns. The only soy I recommend is natto, which is a fermented soy product. Just be aware that it’s
high in linoleic acid — upwards of 40-50% — so eat it sparingly. Fermentation neutralizes many of soy’s antinutrients, improves digestibility, and increases nutrient absorption. Read “Soybean Oil Linked to Genetic and Neurological Damage” to learn more.

• When to consider protein powder — Protein powders are helpful when meeting your daily protein goal through whole foods isn’t practical. They’re useful if you train regularly, travel often, or have limited time to prepare full meals. They also help maintain steady intake during recovery, illness, or aging, when digestion or appetite may slow.

Find out what to look for in a protein powder and how to incorporate it into your routine in “Protein Powders: A Complete Guide for Better Health.”

No matter which sources you rely on, the goal is to build your meals around high-quality protein without sidelining other essentials. Pair your protein with healthy fats, clean carbohydrates, and whole fruits and vegetables. When protein becomes a consistent part of a well-rounded plate, it not only meets your daily needs — it supports long-term health.

Frequently Asked Questions (FAQs) About the Timing of Your Protein Intake

Q: Is morning a good time to eat protein?
A: Yes. Morning is a strategic time to include protein into your meal because it replenishes amino acids after an overnight fast and helps set the tone for balanced metabolism and hormone activity through the day. It also keeps you full longer by lowering ghrelin and raising satiety hormones like GLP-1 and peptide YY.

Q: Do I need protein right after a workout?
A: Yes. After training, your muscles are primed to absorb amino acids and begin the repair process. Aim to eat a protein-rich meal within about two hours of finishing exercise. Most adults benefit from 20 to 40 grams, depending on body size and activity level.

Q: Is protein before bed good or bad?
A: It’s good. Eating a slow-digesting protein like casein before bed provides a steady flow of amino acids overnight, helping maintain muscle and support tissue repair. Options like Greek yogurt, cottage cheese, or A2 milk are effective choices.

Q: How much protein per day is ideal?
A: That depends on your total daily goal, which is based on your ideal body weight. There are several ideal body weight calculators online that are easy to use. Just plug in your age, gender, and height and the calculator will give you a range based on commonly used formulas. Most adults need around 0.8 grams of protein per pound of ideal body weight daily. Divide that evenly across your meals.

Q: Is total protein intake more important than timing?
A: Both matter, but total intake carries more weight. Once your total need is met, spreading protein evenly throughout the day helps your body use it more efficiently and maintain a steady supply of amino acids for repair and energy.

Q: Do I need protein powder?
A: Not necessarily. Whole foods should always be your foundation since they provide complete nutrients and a better amino acid balance. Protein powder is only useful when it’s difficult to meet your daily needs, such as during heavy training, travel, illness, or loss of appetite.

Your liver could be scarring right now, and you might not know it. Liver fibrosis, the gradual buildup of scar tissue from repeated metabolic stress, produces no symptoms in its early stages. By the time fatigue, discomfort, or blood work abnormalities surface, the damage is often well underway. Left unaddressed, this process may progress into more serious conditions like cirrhosis, liver failure, or liver cancer.

Recent findings published in JAMA Network Open highlight a shift in how this condition is understood.1 Instead of focusing only on how common liver disease is, the research points to how it progresses under different metabolic conditions. The data suggest that underlying metabolic stress — not just the presence of disease — plays a central role in how quickly liver damage develops and worsens over time.

Liver health is tightly tied to how your body manages energy. Factors like blood sugar control, fat distribution, and overall metabolic balance influence how much strain your liver faces every day. When these systems fall out of alignment, your liver absorbs that burden, and the repair process turns into a cycle of damage and scarring. What’s more, the same metabolic signals lead to very different outcomes depending on your biology.

Metabolic Risks Hit Women’s Livers Harder

A study published in JAMA Network Open analyzed 5,981 U.S. adults in a cross-sectional observational analysis using data from the National Health and Nutrition Examination Survey between 2017 and 2020, aiming to understand how common metabolic problems affect liver scarring differently in men and women.2

Researchers used a specialized scan that measures how stiff the liver is — higher stiffness means more scarring. The goal was to identify which risk factors matter most and who they impact the hardest.

• Women show higher risk despite lower overall rates — The population included nearly equal numbers of men and women, with an average age in the late 40s. While men had a higher overall rate of significant liver fibrosis at 10.7% compared to 6.9% in women, the pattern flipped when specific metabolic problems were present. Women experienced a much sharper increase in risk once those triggers appeared, suggesting the condition may escalate more quickly.

• Central body fat shows a strong risk association — Women had a much higher prevalence of central fat, with 69% exceeding the risk threshold compared to 48.6% of men. More importantly, the impact of that fat differed dramatically. Women with high waist circumference had over 13 times higher odds of significant fibrosis, compared to about 4.4 times higher odds in men. This shows that where fat is stored matters more than total weight, especially for women.

• Blood sugar problems show stronger associations with liver damage in women — Another key factor was glucose intolerance, which refers to difficulty regulating blood sugar. Even though fewer women had this issue compared to men, its effect on liver health was stronger in women. Women with glucose intolerance had nearly three times the odds of fibrosis, compared to about 1.5 times in men.

• Multiple metabolic issues multiply the danger rapidly — People with two or more cardiometabolic risk factors, such as high blood pressure, unbalanced cholesterol levels, or elevated blood sugar, had an increased risk. In women, this combination increased fibrosis risk more than tenfold, compared to less than threefold in men. This stacking effect means each additional issue compounds the stress on your liver.

Key Metabolic Drivers Behind Liver Fibrosis

Interestingly, not every metabolic issue carried the same weight. Conditions like high blood pressure, high triglycerides, and low HDL cholesterol showed similar effects between men and women. The study highlights central fat and blood sugar control as the most important levers to watch closely.3

• Inflammation from visceral fat fuels liver scarring — Visceral fat — the fat stored deep around your organs — behaves differently from fat under your skin. It releases inflammatory signals and disrupts insulin sensitivity, meaning your body struggles to manage blood sugar efficiently. That combination may create ongoing stress that contributes to liver damage and scarring over time.

• Impaired glucose control disrupts energy inside liver cells — Research suggests that when blood sugar stays elevated or unstable, your liver may convert excess glucose into fat, which accumulates in liver tissue. This buildup interferes with normal cellular function and creates oxidative stress, a process where unstable molecules damage cells. Over time, this may contribute to fibrosis as your liver attempts to repair itself repeatedly.

• Stacked metabolic stress overwhelms repair systems — When multiple risk factors occur together, your liver faces simultaneous pressures — inflammation, fat buildup, and metabolic dysfunction. Instead of recovering, the tissue shifts into a cycle of injury and repair that replaces healthy cells with scar tissue. This may help explain why having more than one issue was associated with faster progression rather than simply slightly higher risk.

Address the Root Causes Driving Liver Fibrosis

The encouraging takeaway is that the same metabolic levers driving fibrosis are the ones you have the most control over. Visceral fat and blood sugar regulation are areas where dietary and lifestyle changes may help.

Your liver reflects what you feed it and how you live day to day. The patterns that drive fibrosis don’t act in isolation. They stack. Once they do, your liver shifts from repair mode into damage mode. Turning that around requires removing the stressors first, then giving your body what it needs to clear fat and restore function.

1. Remove vegetable oils and alcohol to help reduce ongoing liver stress — If your diet includes packaged or restaurant foods made with soybean, canola, corn, or generic “vegetable oil,” your liver deals with a constant stream of linoleic acid (LA).

This fat breaks down into harmful compounds called oxidized linoleic acid metabolites (OXLAMs), reactive byproducts that embed themselves in cell membranes, making them fragile and triggering a chain of inflammatory signals your liver has to process on top of everything else.4

At the same time, alcohol breaks down into acetaldehyde, a highly reactive compound that poisons the energy-producing machinery inside your liver cells, slowing their ability to detoxify and repair. Both of these — vegetable or seed oils and alcohol — interfere with your liver’s ability to detoxify and regenerate. Removing them reduces the ongoing stress that drives fibrosis, especially if signs like belly fat or poor blood sugar control are already present.

2. Use choline-rich foods that may help reduce fat accumulation in your liver — Research suggests choline helps keep fat moving through your liver rather than building up inside liver cells. Without adequate choline, fat may accumulate, potentially increasing inflammation and scarring risk.5 Think of choline as your liver’s loading dock — it keeps fat packed and shipped out. When choline runs low, the dock backs up and fat accumulates inside the organ.

Pastured egg yolks offer one of the most effective sources, especially when sourced from eggs low in polyunsaturated fats. Grass-fed beef liver provides another highly absorbable option. This nutrient is involved in forming phosphatidylcholine, which your liver uses to package and export fat.6 When that process works properly, one of the factors associated with fibrosis may be reduced.

3. Use targeted choline supplementation when food intake falls short — If your diet doesn’t include enough animal-based foods, reaching adequate choline intake is difficult. Plant sources contain only small amounts, and relying on them alone leaves a gap. In that case, supplementation may be worth considering to support liver function.

Some research has examined citicoline as a potential option, with doses in some studies ranging from 500 mg to 2,500 mg per day. Consult your health care provider before beginning any supplement regimen. At that level, research suggests it may support your liver’s ability to move fat out while also potentially increasing acetylcholine production in your brain, which may help support cognitive function.7,8

4. Stay active daily to reduce visceral fat and improve metabolic control — Regular activity improves how your body handles blood sugar and reduces the deep abdominal fat tied to liver scarring. This doesn’t require extreme workouts. Regular brisk walks, consistent daily movement, and simple resistance exercises keep blood flowing and metabolic signals balanced.

If your waist circumference exceeds 40 inches for men or 35 inches for women, that signals visceral fat accumulation — the type most strongly linked to liver damage. Reducing that measurement has been associated with lower risk.

5. Focus on simple, whole meals that reduce metabolic strain — Each processed meal reloads the same metabolic triggers — unstable fats, refined carbohydrates, and chemical additives — that research has associated with fibrosis progression. These may disrupt energy production and increase inflammation inside your liver. Replacing them with whole, nutrient-dense foods stabilizes blood sugar and reduces the burden on your system.

That shift may help redirect signaling inside your liver from fat storage and damage toward clearance and repair.

FAQs About Liver Fibrosis and Metabolic Risk

Q: What is liver fibrosis and why is it dangerous?

A: Liver fibrosis is the buildup of scar tissue that forms when your liver is repeatedly stressed or injured. Over time, this scarring interferes with normal liver function. Early stages often have no symptoms, which is why it goes unnoticed. As it progresses, it can contribute to fatigue, discomfort, and reduced energy. If it continues unchecked, it can advance into cirrhosis, liver failure, or liver cancer.

Q: What are the main drivers of liver fibrosis?

A: Research suggests the main drivers are metabolic issues that disrupt how your body handles energy. These include excess abdominal fat, poor blood sugar control, and multiple cardiometabolic risk factors occurring together. When these stack up, your liver may face constant stress from inflammation, fat buildup, and metabolic dysfunction, which is associated with accelerated scarring.

Q: Do men and women face the same risk of liver fibrosis?

A: No. While men show higher overall rates of liver fibrosis, the study found that women experience a much sharper increase in risk once certain metabolic problems are present. This suggests the condition may escalate more aggressively in women when key risk factors appear, even if baseline rates are lower.

Q: How does fat buildup actually damage the liver?

A: When your body can’t properly manage blood sugar, research suggests that excess glucose may be converted into fat and stored in your liver. At the same time, visceral fat releases inflammatory signals that disrupt normal metabolism. This creates a cycle where your liver keeps trying to repair itself, but repeated stress leads to scar tissue replacing healthy cells.

Q: What dietary and lifestyle strategies may be worth considering?

A: Focus on removing the root causes and restoring metabolic balance. Eliminating vegetable oils and alcohol reduces toxic stress on your liver. Supporting fat clearance with choline may help reduce buildup inside liver cells. Daily movement lowers visceral fat and improves blood sugar control. Replacing processed foods with whole, nutrient-dense meals stabilizes your metabolism and reduces inflammation, which may support your liver’s ability to recover.

This article is for informational purposes only and does not constitute medical advice. Consult a qualified healthcare provider before making changes to your health regimen.

Test Your Knowledge with Today’s Quiz!
Take today’s quiz to see how much you’ve learned from yesterday’s Mercola.com article.

Which of the following is not a seed oil?

Tallow
Tallow is an animal fat, while soybean, canola, and sunflower oils are seed oils high in linoleic acid. Learn more.
Soybean oil
Canola oil
Sunflower oil

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A New Series of Health Insights Is on the Way
Our team has been working behind the scenes to prepare new research and practical health strategies for our readers. While we finish preparing what’s coming next, we invite you to explore one of the most-read articles from our library below. See exactly what’s changing →

Every step you take depends on your hips doing their job. They aren’t just joints; they’re command centers for movement. When they stop functioning well, everything else pays the price. You might notice your knees aching, your back tightening or your balance getting worse. But what’s actually going wrong starts higher up: your hips have lost control.

The problem usually begins quietly. Sitting too much changes how your muscles fire. Hips tighten. Glutes weaken. Your body adapts but not in your favor. Over time, that compensation becomes the new normal, and eventually, movement becomes strained, inefficient or painful. You might blame the wrong area entirely. What most people overlook is how fast the damage builds — and how fixable it really is.

The key isn’t stretching more or working out harder. It’s retraining your hips to move the way they’re meant to, restoring balance before pain spreads further. Understanding this root cause changes the way you look at mobility and reveals the key exercises needed to improve it.

This Hip Routine Trains Your Body to Move Better, Starting with 6 Moves

A New York Times article explored how simple hip exercises reverse damage from sitting. It focuses on how long periods of sitting weaken your glutes and tighten your hip flexors, two key muscle groups that support your entire lower body.1

Over time, this leads to poor alignment, reduced mobility, and pain in other joints that are forced to compensate. While it’s important to minimize the amount of time you spend sitting each day, a short, consistent set of exercises helps reverse the damage and restore balance in your body. These six moves work together to restore proper hip function, ease tension, and retrain your muscles to fire in the correct sequence.

• Hip rotations reset your range of motion — Stand straight, holding on to the back of a chair or countertop. Lift your left knee to a 90-degree angle and place a tennis ball behind the knee. The ball acts as a cue to make sure you’re squeezing your heel toward your buttocks. Slowly rotate your knee outward, keeping the rest of your body still, until you reach your end range.

Next, drive your heel upward toward the ceiling as far as you can, then rotate the leg backward. Lower the knee and drive your heel upward. Hold for a few seconds, then lift your knee toward your chest. Next, reverse the motion series as demonstrated in the video below.

• 90/90 hip rotations improve internal and external rotation — Sit on the floor with your knees bent and legs forming two 90-degree angles. Lean back slightly with your hands behind you. Move both knees from side to side like windshield wipers, then advance to deeper positions by bringing your hands off the floor. This move unlocks rotation that’s lost in most people who sit too long and don’t train lateral movement.

• The side-lying hip shift reactivates your glutes and inner thighs — Lie on your side with a foam roller or ball between your knees. Keeping your upper body still, slide your top knee forward and back as far as it can go. This is a low-impact move that stretches tight inner thighs and trains your glutes to activate in tandem. You’ll feel it instantly in the muscles that protect your pelvis and stabilize your stride.

• Lateral lunges bring back side-to-side stability — From a standing position, take a big step out to one side and bend that knee into a lunge. Keep your opposite leg straight and push your hips back. This strengthens your hip stabilizers that keep your knees from collapsing inward. Most people don’t train lateral motion, and it shows up as instability during squats, lunges or quick direction changes.

• Romanian deadlifts reinforce proper hip hinging — Stand tall with a soft bend in your knees. Slide your hands down your thighs as you hinge your hips backward. Go slowly until you feel a stretch in your hamstrings, then squeeze your glutes to return to standing. This move teaches you how to move from your hips, not your back, while building strength and control in your glutes and posterior chain, which includes all the muscles that connect to your pelvis.

• Glute bridges restore hip extension and wake up dormant muscles — Lie on your back with feet flat and knees bent. Drive through your heels and lift your hips as high as possible while keeping your shoulder blades on the floor. Pause at the top and focus on squeezing your glutes before lowering. To make it harder, do single-leg versions or add resistance with a dumbbell or resistance band.

5 Hip-Focused Movements to Rebuild Strength, Mobility, and Pelvic Control

CNN laid out five foundational hip exercises designed to restore balance and mobility where it matters most.2 Written by certified strength and conditioning coach Dana Santas, the article focuses on how tight hip flexors and weak stabilizing muscles create a cascade of movement issues.

Her targeted routine doesn’t require fancy equipment or extreme flexibility. Instead, it’s a structured way to reintroduce strength, coordination, and freedom of motion to one of the most important movement hubs in your body — your hips.

• Begin with soft-tissue release to unlock tense hip muscles — Before doing any mobility or strength work, Santas recommends using a foam roller or massage for 30 to 60 seconds per muscle group. Focus on your glutes, outer thighs, quads, hamstrings, and inner thighs.

This primes your nervous system, increases circulation and breaks up the rigidity that builds from long bouts of sitting or repetitive movement patterns. A 10-minute sample routine focused on hip pain relief is presented below.

• Use a three-way hip flexor release to restore full extension — Modern lifestyles shorten your hip flexors and pull your pelvis into poor alignment. Santas’ go-to fix is the three-way release, which moves your hip through forward, lateral and diagonal patterns. This helps reintroduce natural range and allows your body to reconnect with full hip extension — a movement pattern required for walking, running, and lifting with proper form.

• Rebuild inner thigh and glute strength with a block-supported glute bridge — This variation of a glute bridge brings in your adductors, a group of muscles located on the inner thigh, which are often weak from underuse.

Lie down with knees bent and a yoga block or rolled towel between your knees. Lift your hips a few inches while squeezing the block, keeping your core engaged and movement slow. This helps reactivate the stabilizers that control how your hips move through space — key for building lasting strength and control.

• Lateral lunges reintroduce movement in neglected planes — Most workouts and daily activities move your body forward and backward. But your hips are built to move in all directions. Lateral lunges train your body to step out of that plane and strengthen the muscles needed for side-to-side movement, balance and stability. Santas encourages slow, deliberate reps to build strength and coordination, not just flexibility.

• Swap aggressive hip stretches for safer, more supportive positions — Santas suggests using stretches that allow you to control the angle and avoid joint strain. The first option is the seated figure-four stretch, where you cross one ankle over the opposite knee while sitting in a chair.

The second is a modified pigeon pose, using a couch or sturdy box. This pose is a supported stretch that targets your hips without putting excess strain on your knees or lower back.

To do it, place one shin across the seat of the couch so your knee and ankle rest on the cushion. Your other leg stays behind you in a kneeling lunge position with your hips facing forward. Keep your torso upright or gently lean forward over the front leg to deepen the stretch. This variation allows you to stretch your glutes and outer hips while keeping your joints stable and supported. It’s ideal if the conventional floor-based pigeon feels too intense or unstable.

3 Hip Drills to Rebuild Power, Posture, and Balance

In an article from Men’s Health, fitness trainer Lee Boyce outlined a short list of hip-specific drills designed to fix an underlying source of poor posture, weak glutes and tight lower backs.3 These aren’t flashy moves, but they’re targeted to address exactly what many people lack: controlled hip movement. Each drill works a different aspect of mobility, strength, or coordination — and all of them are meant to be quick, effective and repeatable.

• Hip circles unlock range of motion and coordination — Start on all fours with your knees under your hips. Slowly lift one leg outward and rotate it in a wide arc, then reverse the motion. Your torso should stay completely still — no twisting, no leaning. This move reintroduces your brain to the full 360-degree rotation your hip joint is designed for. It’s especially useful if you feel stiff getting up from a chair or tight when stepping sideways.

• Seated hip lifts build raw flexor strength and improve stride control — Sit upright with your legs straight in front of you. Place a kettlebell, foam roller or any small object near one ankle. Keeping your leg extended, lift it up and over the object without leaning back or twisting. This isolates your hip flexors and teaches them to activate cleanly. If you struggle to clear the object, that’s a sign your hip strength is lagging, and your stride length and balance are suffering because of it.

• The crescent lunge resets posture and lengthens tight hip flexors — Drop into a half-kneeling position with one foot forward and the other knee on the ground. Squeeze your glute on your back leg and push your hips forward while reaching both hands overhead. This lengthens your hip flexors while engaging stabilizer muscles and straightening out pelvic tilt.

A New Series of Health Insights Is on the Way

VIKTIG

A New Series of Health Insights Is on the Way
Our team has been working behind the scenes to prepare new research and practical health strategies for our readers. While we finish preparing what’s coming next, we invite you to explore one of the most-read articles from our library below. See exactly what’s changing →

Hair loss is often dismissed as a cosmetic issue, but it’s actually one of the clearest signs your body is under stress. When your energy reserves are low and your stress hormones stay elevated, your hair follicles go dormant — and in some cases, shut down entirely. In a nutshell, your body prioritizes survival when resources run low.

One overlooked factor is the impact of intermittent fasting or time-restricted eating, also known as TRE. While often praised for boosting metabolic health and accelerating fat loss, TRE, just like longer fasting regimens, can in some cases cause problems. Fasting triggers a hormonal response designed to help you cope with food scarcity, but that response comes at a cost.

Your body switches fuel sources, ramps up stress hormones, and alters how fat and energy are used at the cellular level. That shift directly affects the tissues that require the most energy to grow and regenerate, including your hair.

Emerging research is now confirming what many people have experienced firsthand: fasting doesn’t always work in your favor, especially when it comes to regenerative health. It activates a cascade of stress responses that reach your skin, your fat stores, and your stem cells. And instead of building resilience, it often erodes it. In the next section, I’ll walk you through what the researchers found and how this process plays out at the cellular level.

Fasting Fuels Hair Loss by Flooding Your Cells with Toxic Fat

Bioenergetic researcher Georgi Dinkov highlighted what happens to your cells when your body burns fat for fuel during intermittent fasting.1 He explains that when your body runs out of sugar (glucose), it turns to fat stores, breaking them down in a process called lipolysis. But instead of this being a “clean burn,” it dumps free fatty acids into your bloodstream, which act like a slow poison for your cells, especially in your skin and organs.

• Trying to lose fat through fasting costs you muscle and long-term health — Dinkov warns that fasting isn’t selective; it doesn’t just target fat. You also lose muscle. In fact, studies show that for every pound of fat lost, people may lose up to two pounds of muscle.

This drains your structural strength, slows your metabolism and leaves your body with fewer resources to heal and recover. Worse, the fat you do break down releases toxic byproducts that directly harm your tissues, including your skin and scalp.

• Your body floods with harmful fatty acids when sugar runs out — Once your glycogen (stored sugar) is used up, fasting kicks off a flood of free fatty acids. These aren’t clean energy — they’re unstable and highly reactive.

Dinkov points out that they create oxidative stress, damage your energy-producing mitochondria, and often lead to fibrosis, or scar-like tissue, in key organs like your liver. In plain terms: what’s supposed to be a fat-burning “cleanse” ends up polluting your system from the inside out.

• Hair follicles get hit hard when your energy source shifts to fat — Hair growth depends on high-energy stem cells that prefer to run on glucose, not fat. When fasting forces your body to burn fat instead, those cells start to struggle.

Dinkov writes that this disrupts the entire regeneration cycle and “greatly inhibits the growth of hair.” If you’ve experienced hair thinning, shedding or loss during or after a fasting period, this switch in energy source could be a major reason why.

• Even healthy people show signs of organ stress from fasting — You don’t need to have diabetes or a metabolic condition to see damage from fasting. Dinkov highlights that elevated free fatty acid levels have been tied to liver and kidney damage even in people who are otherwise healthy. So, if you’re fasting to stay “fit,” you’re trading short-term weight loss for long-term stress on your organs.

• Fasting puts your body into a chronic stress response — When glucose runs low, your body activates the hypothalamic-pituitary-adrenal (HPA) axis — your emergency stress system. This floods you with adrenaline and cortisol, which break down muscle and fat to try and keep you going.

But this system is designed for short bursts of danger, not long-term daily use. The longer you push this stress response, the more damage it causes, especially to skin and hair. Dinkov sums it up bluntly: stop pushing your body to the edge. “Maybe, just maybe, don’t fast (or otherwise stress yourself) to start with.”

Your Hair Follicles Shut Down When You Fast Too Long

A peer-reviewed study published in Cell explored how intermittent fasting disrupts hair follicle regeneration through a specific stress response between your adrenal glands and the fat cells in your skin.2 The researchers wanted to understand how fasting influences tissue repair, and they focused on hair follicle stem cells (HFSCs), which are essential for new hair growth. Their key question: does fasting affect the metabolism and survival of these cells?

• Researchers tested popular fasting methods and found the same harmful outcome — The study included mice exposed to two common fasting regimens — alternate-day fasting and 16:8 time-restricted eating, where food intake was limited to an eight-hour window followed by a 16-hour fasting period.

Both forms triggered a near-identical biological reaction: HFSCs stopped regenerating and began dying off. Importantly, this effect occurred even though total calorie intake remained the same, suggesting it wasn’t caused by nutrient deprivation but by the fast-feed cycle itself.

• Human trials confirmed that fasting stalls hair growth — In addition to animal models, researchers ran a randomized clinical trial on humans. Participants followed an intermittent fasting routine and had a small patch of scalp shaved to monitor hair regrowth.

The results were clear: those on fasting protocols showed noticeably slower regrowth compared to those who ate normally. This directly connected fasting habits to visible changes in the rate of hair returning.

• This effect has nothing to do with calories or circadian rhythm — Researchers ruled out some usual suspects. Mice in both groups ate the same number of calories over time. Time-of-day variations didn’t matter either — fasting at night or during the day triggered the same level of HFSC death. This shows the culprit isn’t under-eating or bad timing. It’s the stop-start energy availability from fasting that wreaks havoc on stem cells.

• The stress signal starts with your adrenal glands and ends in your skin — Under fasting conditions, your adrenal glands ramp up production of corticosterone and epinephrine — two hormones that act like emergency messengers. These hormones prompt dermal fat cells to dump fatty acids into the tissue, leading to cell damage and death.

The More You Fast, the Faster Your Hair Stem Cells Die

A paper published in Life Metabolism also explained that intermittent fasting directly alters the way hair stem cells function, shifting them into a metabolic state that ends in programmed cell death, also known as apoptosis.3

• Hair follicles stalled in the resting phase and refused to regrow — Research has shown that intermittent fasting keeps hair follicles stuck in the telogen, or resting phase, of the hair cycle. Normally, after a brief pause, follicles are supposed to re-enter the anagen, or growth phase. But in fasted mice, this transition never happened. Hair stayed dormant.

• The hair stem cell pool was actively depleted over time — Early in the fasting cycles, hair stem cells briefly activated as expected. But with repeated fasting, these same stem cells began dying off instead of renewing.

Over time, the pool of viable HFSCs shrank dramatically. This led to not just slower regrowth but actual degeneration of the follicles themselves. Unlike other tissues where fasting sometimes increases stem cell resilience, this effect was destructive in hair follicles.

• Blocking fat metabolism protected hair stem cells — To confirm what was killing the cells, researchers genetically blocked fatty acid oxidation in HFSCs. When those metabolic pathways were shut down, the cells stopped dying, even during fasting.

Similarly, when fasting-triggered free fatty acids were artificially introduced into the tissue, stem cells began dying again. The link was clear: fasting increases free fatty acid exposure in the hair niche, and those fatty acids are toxic to stem cells when used as fuel.

• Mitochondrial damage was the last straw for the stem cells — Under the microscope, fasted HFSCs showed signs of mitochondrial breakdown, including distorted shapes, leaky membranes, and dysfunctional production of adenosine triphosphate (ATP), the fuel that powers everything from brain function to hormone balance.

Lab markers also showed increased reactive oxygen species, DNA damage and oxidative stress — all signs of a cell under extreme pressure and unable to cope. Once these stress markers surpassed a certain threshold, the cell’s natural suicide program kicked in.

Does This Mean All Fasting Is Bad?

It’s important to clarify that not all fasting is harmful. In fact, TRE can offer real benefits when used wisely. TRE — such as eating all your meals within an eight-hour window and fasting for 16 hours — has been shown to support autophagy, improve insulin sensitivity, and promote metabolic flexibility. The key is knowing when and how to use it.

If you’re experiencing hair loss, fatigue, or other stress-related symptoms while following TRE, it’s likely because you’re not eating enough carbohydrates during your feeding window. Make sure you’re getting around 250 grams per day to restore balance. If that doesn’t resolve the issue, consider widening your eating window to 10 or 12 hours, or adopting a more regular meal schedule.

For some people, not fasting at all and eating every four hours works best — especially if you’re dealing with low energy, chronic fatigue, or signs of metabolic burnout. But there’s a catch: you can’t just graze on junk food. If your goal is to restore healthy energy production at the cellular level, your body needs a steady supply of quality carbohydrates throughout the day. That means reaching for clean sources like white rice, well-tolerated grains, ripe fruits, and cooked vegetables.

And here’s another layer of nuance: if your gut is compromised — think bloating, constipation, or post-meal discomfort — high-fiber carbs might make things worse, not better. In that case, start with low-fiber carbs and slowly work your way back to fiber-rich options as your digestion improves.

As for longer fasts — lasting 24 hours or more — they too have a place in cases of extreme obesity or serious metabolic dysfunction. But these extended fasts should be treated like medical interventions, not long-term habits. When used too frequently, they can trigger muscle wasting, elevate stress hormones, and leave your body in a chronically depleted state.

So, it’s not that fasting has no value. It’s that the benefits come with trade-offs. And if you’re seeing hair loss, declining energy, or slower recovery, that’s your body signaling it’s time to adjust the approach — not double down. Ultimately, fasting is a tool, not a default setting. Whether you fast for eight hours, 24 hours, or not at all, what matters most is how you nourish yourself when you do eat. If you’re under-eating, skimping on carbs, or over-relying on fat as fuel, the drawbacks will eventually catch up to you.

Stop Starving Your Hair and Feed It What It Actually Needs

If you’ve been doing intermittent fasting and started noticing your hair thinning, falling out faster than usual or just refusing to grow, this is your wake-up call. Here’s where I recommend starting:

1. Balance your fat to carb intake — Your hair stem cells aren’t designed to run on fat. When you fast, your body dumps free fatty acids into your system, which poisons the follicle environment. Keep your fat intake between 30% and 40% of total calories, and carbs around 45% to 55%.

2. Aim for 250 grams of healthy carbs per day, and more if active — If you’ve been eating low-carb, this may feel like a lot, but this is what your cells need to make ATP efficiently. Carbs spare your protein reserves, stabilize your blood sugar, lower stress hormones and keep your hair follicles from going dormant.

Start with white rice and whole fruit. Add well-cooked root vegetables next. Hold off on raw greens, whole grains and beans until or unless your gut is healthy, meaning your bowel habits, bloating and overall comfort are under control.

3. Reduce your fasting window — Widen your eating window to 10 or 12 hours. If problems persist, consider adopting a more regular meal schedule.

4. Use near-infrared light therapy to boost cellular energy — Low-level laser therapy, especially using near-infrared wavelengths, stimulates your mitochondria to release nitric oxide and produce more ATP. These three — mitochondria, NO, and ATP — work together to trigger healing effects like DNA repair and cellular regeneration, including in hair follicles. You can get many of these hair growth-stimulating benefits by using a zero-EMF near-infrared sauna.

5. Rebuild hair strength by fixing nutrient deficiencies — Your hair relies on certain nutrients to grow and stay anchored in your scalp. If you’re missing key nutrients like vitamin D, B12, or vitamin A, shedding is often one of the first signs. The best way to fix this is through a nutrient-dense, whole food diet. If your hair loss continues, I recommend seeing a holistic doctor for a full blood panel.

With those results, target specific deficiencies using food or supplements and get your body back on track. The key is consistency. Your body — and your hair — need to know that nourishment is always coming.

FAQs About Intermittent Fasting and Hair Loss

Q: Why does intermittent fasting cause hair loss?
A: Intermittent fasting triggers a stress response in your body that leads to lipolysis — the breakdown of stored fat — which floods your system with free fatty acids. This forces your hair follicle stem cells to burn fat for energy, a process that produces toxic byproducts like reactive oxygen species. These stress signals ultimately kill off the stem cells needed to regenerate new hair.

Q: What did research show about the effects of fasting on hair follicles?
A: A clinical trial published in Cell found that intermittent fasting actively suppressed hair growth in humans by triggering stress signals between the adrenal glands and skin fat cells.4 This disrupted the metabolism of hair stem cells, causing them to die off instead of renewing and growing new hair.

Q: If fasting harms hair growth, what should I do instead?
A: The solution is to make sure you’re eating enough healthy carbs when you do eat, and/or widen your eating window. If necessary, stop intermittent fasting and shift to regular, nourishing meals every three to four hours. Prioritize carbohydrates, especially white rice and whole fruits, to provide your cells with glucose, which is their preferred fuel source. Avoid low-carb diets and instead focus on fueling your body with digestible, balanced meals.

Q: Is hair loss from fasting permanent?
A: If caught early, hair loss due to fasting is often reversible. Once you stop the fasting cycle and reintroduce consistent energy through food, especially glucose, your body begins regenerating hair. However, prolonged stem cell damage from repeated fasting could result in lasting follicle loss, so early intervention is important.

Q: How many carbs should I eat to support hair and metabolic health?
A: Most adults need 250 grams of carbohydrates daily to support optimal mitochondrial function and hair growth. If you’re physically active or recovering from stress or restrictive eating patterns, your needs will be even higher. The goal is to eat enough to keep your body out of energy deficit and allow your cells to thrive.

The immune cells patrolling your body right now are built from the fats you ate this week. And according to a March 2026 study in Nature, the wrong fats can cause those cells to literally self-destruct — their membranes rupturing from the inside out.1 In fact, researchers uncovered a direct mechanism linking everyday food choices to the physical integrity of the cells your body depends on to fight infections and cancer.

A separate comprehensive review published in the journal Nutrients2 reinforces this picture from a broader angle, showing that fatty acids influence immune behavior across virtually every category of defensive cell in your body.3 Together, these studies make a compelling case that the fat composition of your diet is one of the most underappreciated factors shaping your resistance to disease.

Your Immune Cells Are Built from the Fats You Eat

For the Nature study, researchers looked at how the fats in your diet affect the health and survival of T cells — the immune cells that organize your body’s defense against infections and cancer.4 These scientists examined how different fats from food become part of the outer layer of these cells and influence whether the cells stay strong or break down when the body is under stress.

The study focused on a specific way immune cells die — their outer membrane literally breaks apart after oxygen damages the fats embedded in it. Scientists call this process ferroptosis, and it’s driven by iron-dependent reactions that attack vulnerable fats in the membrane. When this happens, the immune cell dies. By studying how different dietary fats influence this process, the researchers showed that the types of fats you eat appear to directly influence how durable your immune cells are.

• The fats you eat determine how strong or fragile your immune cells become — Researchers found that the balance of fats inside T cells plays a major role in whether those cells remain stable or break down under stress.
When T cells contain higher amounts of polyunsaturated fats (PUFs) — commonly found in seed oils such as soybean, corn, canola, sunflower, and safflower oil — compared to monounsaturated fats like those found in olive oil and avocados, the cell membranes become much easier to damage.
These unstable fats react quickly with oxygen, making the membrane fragile. One key discovery was how quickly fats from food become built directly into the outer wall of immune cells. When those membranes contain large amounts of unstable PUFs, oxidation spreads rapidly across the membrane — much like a row of dominoes falling once the first piece tips over.
Some fats create fragile membranes that break down easily, while others create stronger, more stable structures. Over time, the fats you regularly eat determine whether your immune cells remain durable defenders or become short-lived and vulnerable during immune stress.
• Stronger T cells created stronger immune responses — When researchers adjusted the fat composition of T cells so that their membranes contained more stable fats, the cells lived longer and performed their roles more effectively.
The study highlighted improvements in follicular helper T cells, which help your body produce antibodies.5 These antibodies are the proteins your immune system makes to recognize and fight infections. When these helper cells remain healthy, your body produces stronger and longer-lasting immune protection.
• Protected T cells were better at fighting tumors — Scientists also studied how fat composition affected the ability of T cells to attack cancer cells. When the cells were protected from ferroptosis, they maintained their tumor-fighting activity for longer periods. This is important because many cancer treatments depend on strong immune cells that remain active long enough to destroy abnormal cells.
• Certain fats made immune cells much more fragile — The researchers observed that membranes rich in PUFs were especially vulnerable to oxidation. These fats contain chemical bonds that react easily with oxygen, which makes them unstable. Once oxidation begins, the damage spreads quickly through the membrane and triggers ferroptosis, which acts like a destructive chain reaction.

Fats Help Control How Strongly Your Immune System Reacts

The Nature study showed what happens at the membrane level of a single cell type. But your immune system doesn’t run on T cells alone. A comprehensive review in Nutrients reveals that dietary fats may shape the behavior of virtually every category of immune cell in your body — and the effects go beyond structural damage.6

The researchers’ goal was to understand how dietary fats influence the way immune cells communicate, trigger inflammation, and protect your body from harmful microbes. They found that fatty acids play two important roles inside immune cells.

First, they help form the structure of the cells themselves. Second, they act as chemical signals that tell immune cells how to respond to threats. This means the fats inside your body influence not only the shape of immune cells but also the instructions those cells follow when fighting infection or repairing tissue.

• Different fats influence how strongly immune cells respond to threats — The review found that fatty acids affect the activity of several important immune cells, including macrophages, neutrophils, and dendritic cells. These cells belong to your innate immune system, which acts as your body’s first line of defense. They respond immediately when bacteria, viruses, or damaged tissue appear.
Some fatty acids have been shown to stimulate more aggressive immune responses, increasing inflammation, while others calm the immune response and keep inflammation under control. Maintaining the right balance matters because an overactive immune response damages healthy tissue, while a weak response allows infections to spread.
• Fats help immune cells communicate with one another — One major discovery in the review involves molecules called cytokines. Cytokines are small chemical signals immune cells release to coordinate their response. Think of them as messages sent between immune cells that tell them when to activate, multiply, or slow down.
Fatty acids influence which cytokines immune cells release and how strong those signals become. When the mix of fats inside immune cells changes, the pattern of these signals changes as well. In other words, the fats present in your body influence whether immune cells send strong attack signals or calming signals that reduce inflammation.
• Fats also help protect your body’s physical barriers — The study highlighted another key defense system: the protective linings of your body, including your skin, lungs, and digestive tract. These surfaces act as barriers that stop harmful microbes from entering your body.
Fatty acids influence special proteins called tight junctions, which function like seals between neighboring cells. When these seals remain strong, bacteria and viruses have difficulty passing through. When the seals weaken, harmful microbes slip through more easily and trigger inflammation.
• Certain fats activate built-in immune sensors — The researchers also found that fatty acids interact with receptors inside immune cells. These receptors act like sensors that detect chemical signals and tell the cell how to respond. Some fatty acids activate receptors that increase inflammatory activity, while others activate receptors that reduce inflammation. Fats act like switches that control how strongly immune cells react.
Fats also influence how immune cells produce energy. Immune cells require large amounts of energy to fight infections. Fatty acids affect the metabolic systems inside these cells that generate that energy. Some fatty acids help immune cells produce energy efficiently, allowing them to stay active during infections. Other fatty acids disrupt these processes and weaken immune performance.
• Too much of certain fats is linked to immune-related diseases — The researchers connected fatty acid imbalance to several immune problems, including allergies, asthma, and autoimmune disorders. These conditions develop when your immune system reacts too strongly or attacks harmless substances. Fat composition inside immune cells influences immune tolerance — the ability of your immune system to recognize what’s safe and what’s harmful.
The review concluded that dietary fats influence immune activity in several ways at once, including signaling pathways, gene activity, and the strength of protective barriers. These effects build gradually as eating habits continue day after day. Over time, the types of fats in your diet help determine how effectively your immune system detects threats, coordinates its response, and shuts down inflammation once the danger passes.

5 Ways to Improve Your Dietary Fat Balance for Immune Health

The Nature study demonstrated that the types of fats inside T cells strongly influence whether those immune cells survive or break down under stress. When the balance shifts away from PUFs and toward monounsaturated fats, the cells resist damage and remain functional longer. However, that finding requires an important layer of interpretation.

The study shows that excess PUFs, like linoleic acid (LA) in seed oils, make immune cells fragile, but it doesn’t automatically mean large amounts of monounsaturated oils are the ideal solution. The key lesson is not simply “add more monounsaturated oils.” The deeper message is that modern diets overload your body with unstable fats that damage cell membranes.

Restoring metabolic balance requires removing those damaging oils first and returning to stable fats your body has historically used for energy and cell structure. Once you understand that the fats entering your body become structural components of immune cells and mitochondria — the structures responsible for producing cellular energy — the most powerful step is correcting the fatty acid environment inside your tissues.

Every day your body rebuilds cell membranes using fats from food. When those fats are unstable or metabolically disruptive, immune cells weaken and cellular energy production declines. Fixing the root cause means removing oils that distort metabolism and replacing them with fats that support mitochondrial function and immune resilience.

1. Remove both seed oils and olive oil rather than replacing one with the other — Many people assume olive oil is a healthier substitute for industrial vegetable oils, but that swap fails to solve the underlying problem. Seed oils — including soybean, corn, canola, and safflower oil — contain large amounts of LA, a highly unstable PUF that oxidizes easily and damages cellular structures.
These oils break down during cooking and metabolism into byproducts that interfere with hormone signaling and mitochondrial energy production.
At the same time, relying heavily on oils rich in monounsaturated fat — particularly olive oil, and avocado oil — introduces another problem that often goes overlooked. These oils are dominated by oleic acid, the main monounsaturated fatty acid. While these fats are often promoted as healthy, the picture becomes more complicated when they’re consumed in large amounts.
For starters, many products labeled as olive oil aren’t pure. Investigations found that some store-bought olive oils are adulterated with cheaper vegetable oils.7 That means there’s a strong chance you’re not getting pure olive oil at all, but a blend of seed oils mixed in and sold as a premium product. When that happens, you’re unknowingly consuming the same unstable fats found in soybean, corn, or canola oil.
Even when the oil is genuine, excessive oleic acid creates its own metabolic stress. Some evidence suggests that high oleic acid intake may be associated with disruptions to cellular energy pathways — though the degree of effect varies by context.
Some research suggests high oleic acid intake may be associated with altered fat distribution patterns.8 When mitochondrial efficiency is affected, ATP production may be impacted.
Instead of strengthening metabolism, excessive oleic acid weakens the cellular energy systems your body depends on. Replacing olive oil with vegetable oils only compounds the damage. Rather than swapping one bottle for another, eliminate both oleic-acid-rich oils and vegetable oils from your kitchen entirely.
The goal is restoring a stable fat environment that allows immune cells and mitochondria to function efficiently.
2. Replace unstable oils with traditional animal fats — When you remove problematic oils, your body still requires cooking fats that remain stable under heat. Traditional fats such as grass fed butter, ghee, and tallow provide that stability. These fats contain much lower levels of both LA and oleic acid and resist oxidation during cooking.
Because these fats remain chemically stable, they support mitochondrial function instead of disrupting it. Supporting mitochondrial efficiency with stable dietary fats helps your cells produce energy more effectively.
3. Avoid the major hidden sources of LA in modern diets — The largest sources of LA are processed foods, restaurant meals, and snack products made with seed oils. Most packaged foods, fast foods, and restaurant dishes are cooked with soybean, corn, canola, or similar vegetable oils because they’re inexpensive and shelf-stable. Even if you stop using these oils at home, regularly eating processed foods or restaurant meals continues to expose your body to large amounts of LA.
Another overlooked source of LA is nuts, seeds, and nut butters. Foods such as almonds, walnuts, peanuts, sunflower seeds, and many nut spreads contain substantial amounts of LA. Eating them frequently keeps LA levels elevated in your tissues and slows the process of restoring a healthier fat balance.
The goal is to reduce daily LA intake to below 5 grams, and ideally closer to 2 grams per day. Reaching that level requires removing seed oils, minimizing processed and restaurant foods, and eliminating high-LA foods such as nuts and seeds. Tracking intake makes the process much easier.
The Pax health platform is launching soon and will include Seed Oil Sleuth, that calculates your LA exposure and helps you keep it within the range that supports healthier metabolism and immune function.
4. Choose ruminant meats instead of industrial pork and chicken — Animal feed strongly influences the types of fats stored in meat. Chickens and pigs are monogastric — they have simple stomachs that deposit dietary fats directly into their tissues with minimal conversion. When raised on soy and corn feed, their meat reflects those same unstable fats. When you eat those meats regularly, those same fats enter your body and become incorporated into your cells.
Ruminant animals such as cattle, sheep, and deer process fats differently through their multi-chambered digestive systems. As a result, meats like grass fed beef, lamb, and wild game contain far lower levels of unstable fatty acids and provide a more metabolically stable fat profile.
5. Support cellular repair with the right fuel and proteins — Fixing the fat balance in your diet works best when combined with nutrients that help your cells rebuild healthy membranes and maintain energy production. Your cells generate energy most efficiently when glucose is available as a primary fuel. Most adults thrive on 250 grams of carbohydrates daily, more if you’re active.
Easy-to-digest carbohydrates such as fruit, root vegetables, and white rice provide fuel that mitochondria use to generate ATP efficiently.
Collagen-rich proteins from bone broth or slow-cooked meats are also important, as they provide the amino acids needed to repair connective tissues and cellular structures. Together, these foods help rebuild the metabolic environment that allows your immune cells and mitochondria to function at full strength.

FAQs About Dietary Fat Ratios and Immune Function

Q: How do the fats you eat affect your immune system?
A: The fats in your diet become part of the membranes of immune cells. Research published in Nature showed that when immune cells contain higher amounts of unstable PUFs — commonly found in seed oils — they become easier to damage and more likely to die prematurely.9 When these cells break down too quickly, your immune system loses some of its ability to fight infections and cancer effectively.

Q: Why are seed oils considered harmful for immune cells?
A: Seed oils such as soybean, corn, canola, sunflower, and safflower oil contain large amounts of LA, a PUF that oxidizes easily. When these fats accumulate in cell membranes, they become vulnerable to oxidative damage. This damage can contribute to ferroptosis, a chain reaction that destroys the cell membrane and kills the immune cell. Research suggests that high LA intake weakens immune resilience over time.

Q: Do other types of fats also affect immune responses?
A: Yes. A review published in Nutrients found that fatty acids influence many aspects of immune function, including inflammation, immune signaling, and the strength of your body’s protective barriers.10 Different fats change how immune cells communicate with each other, how strongly they respond to threats, and how efficiently they produce energy during infections.

Q: What are the biggest sources of harmful fats in modern diets?
A: Processed foods, restaurant meals, and packaged snacks are the primary sources of LA because they’re commonly cooked in or made with seed oils. Nuts, seeds, and nut butters are also high in LA. Even when people stop cooking with seed oils at home, regularly eating processed or restaurant foods often keeps their intake of these unstable fats high.

Q: How can I improve the fat balance in my diet to support immune health?
A: Reducing LA intake is an important step. Ideally, lower your daily LA intake to below 5 grams, and ideally closer to 2 grams. This involves removing seed oils, minimizing processed foods and restaurant meals, eliminating high-LA foods such as nuts and seeds, and choosing more stable fats like grass fed butter, ghee, and tallow. Over time, these changes may help rebuild healthier cell membranes and support stronger immune function.

This article is for informational purposes only and does not constitute medical advice. Consult a qualified healthcare provider before making changes to your health regimen.

Test Your Knowledge with Today’s Quiz!
Take today’s quiz to see how much you’ve learned from yesterday’s Mercola.com article.

Which antibiotic is not known to cause long-term damage to gut bacteria?

Clindamycin
Fluoroquinolones
Erythromycin
Clindamycin, fluoroquinolones, and flucloxacillin were linked to major losses in gut bacteria. Erythromycin showed less widespread long-term impact in comparison. Learn more.
Flucloxacillin

A New Series of Health Insights Is on the Way

VIKTIG

A New Series of Health Insights Is on the Way
Our team has been working behind the scenes to prepare new research and practical health strategies for our readers. While we finish preparing what’s coming next, we invite you to explore one of the most-read articles from our library below. See exactly what’s changing →

Benadryl has been a household name for decades, often treated as harmless relief for allergies, coughs, colds, or a restless night. Yet its story is far more complicated. Introduced in the 1940s, it was the first antihistamine of its kind, and for years it was considered a breakthrough. Over time, though, its flaws became harder to ignore as safer and more effective alternatives entered the market.

What makes this important for you is not just history, but the ongoing assumption that something familiar is safe. Many people keep Benadryl in their medicine cabinet because it’s what they grew up with. Few stop to question whether the drug itself has kept pace with modern science or whether newer options could offer the same relief without the risks.

This article takes a closer look at that question. You’ll learn what researchers uncovered about Benadryl’s safety profile, why experts now argue it does more harm than good, and what steps you can take to manage allergies and histamine reactions without turning to a drug that has overstayed its welcome.

Benadryl Is No Longer Worth the Risk

Published in the World Allergy Organization Journal, the analysis examined diphenhydramine’s long-standing role as the first U.S. Food and Drug Administration (FDA)-approved antihistamine in 1946 and concluded that its risks now outweigh its usefulness.1 The authors emphasized that diphenhydramine has reached the end of its medical life cycle, with safer and equally effective alternatives now available.

• Millions of people still use it despite better options — More than 1.5 million prescriptions for diphenhydramine are written every year in the U.S., with far higher numbers of over-the-counter purchases. Surveys show that 62% of adults and 51% of children with seasonal allergies are treated with over-the-counter antihistamines, often Benadryl. Many parents report using it because they grew up with it themselves, assuming it’s still safe.

• The drug causes strong sedation and cognitive impairment — Unlike newer antihistamines, diphenhydramine easily crosses your blood-brain barrier, meaning it directly affects brain function. This results in drowsiness, slower reaction times, memory issues, and poor concentration.

In fact, research cited in the paper found that diphenhydramine had a greater negative effect on driving than alcohol — a shocking finding for a drug sold in nearly every pharmacy.2 The European Union has classified it as “do not drive” due to its sedative power.

• The effects last far longer in certain groups — The paper reported that while children metabolize the drug quickly (with a half-life of around four hours), older adults retain it for much longer, with half-lives of up to 18 hours. That means grogginess and poor alertness carry into the following day, which explains why older users are at higher risk for falls, confusion, and accidents. For students, lingering drowsiness translates into poor academic performance and reduced focus in school.

• Adverse effects stretch beyond drowsiness — Diphenhydramine’s “anticholinergic” effects interfere with the neurotransmitter acetylcholine, which is important for memory, learning, digestion, and muscle movement. This leads to constipation, urinary retention, dry eyes, and dry mouth.

More concerning is the connection between long-term use of first-generation antihistamines like diphenhydramine and dementia. Repeated exposure appears to worsen cognitive decline, making its use especially risky for older adults.

• Children are vulnerable to unpredictable reactions — The paper highlighted paradoxical effects in children, meaning they often become hyperactive, agitated, or confused instead of sedated. When overdosed, they swing to the opposite extreme — significant sedation, coma, or even cardiac arrhythmias.

Most accidental poisonings with diphenhydramine occur in toddlers aged 2 to 4, and ingestion often requires hospitalization or critical care. Some cases have been fatal, underscoring how dangerous this common medicine is when left within a child’s reach.

Medical Authorities Worldwide Are Restricting Diphenhydramine’s Use

Germany, Sweden, and the Netherlands have already limited diphenhydramine to prescription-only status.3 In the U.S., the Federal Aviation Administration (FAA) prohibits pilots from using sedating antihistamines, while allowing non-sedating versions.

Pediatric guidelines in the U.S., Canada, and the U.K. recommend against giving diphenhydramine-containing products to young children, recognizing its risks. The paper strongly recommends moving Benadryl “behind the counter” so pharmacists can guide patients toward safer options.

• The drug is prone to misuse and abuse — Researchers pointed out that diphenhydramine has become popular on social media for dangerous “challenges,” with teens intentionally taking excessive doses.

The FDA has issued warnings after reports of seizures, coma, heart problems, and deaths linked to this misuse. Beyond that, diphenhydramine is often mixed into over-the-counter sleep aids, cough syrups, and cold medicines, creating even more opportunities for misuse.

• Diphenhydramine’s dangers come from two main mechanisms — This includes its ability to cross the blood-brain barrier and its anticholinergic activity. Crossing into the brain leads to sedation, psychomotor impairment, and memory problems. Blocking acetylcholine worsens these effects while also interfering with digestion, urinary flow, and vision. Together, these mechanisms explain why the drug is not only sedating but harmful to long-term brain health.

• Emergency care has already shifted away from diphenhydramine — Until 2019, hospitals relied on intravenous diphenhydramine for severe allergic reactions, but now IV cetirizine is approved and preferred. It provides the same relief with fewer side effects, shorter emergency room stays, and less sedation. This transition highlights how even in acute care, where speed is key, doctors are abandoning diphenhydramine in favor of safer alternatives.

• If you use Benadryl for allergies, colds, or sleep, you’re exposing yourself to unnecessary risks — These include grogginess, memory problems, reduced alertness, and even long-term cognitive decline. Safer alternatives exist and making the switch protects your brain, your safety, and your family’s well-being.

How to Protect Yourself from the Risks of Benadryl

If you’ve been relying on Benadryl for allergies, sleep, or coughs, you’re not alone. Millions of people keep it in their medicine cabinet without realizing how unsafe it is. But instead of masking the problem with a drug that leaves you groggy and at higher risk for accidents, you can take steps that address the root causes and build lasting resilience.

1. Start with an elimination diet to uncover triggers — If you’re struggling with chronic allergies, your first step is figuring out what foods or environmental factors are setting off your immune system. By removing common triggers for a short period and reintroducing them one at a time, you can see what sparks your symptoms.

The key is not complete avoidance forever — that only increases your risk of nutrient deficiencies. Instead, your goal is awareness, so you understand which foods to limit, which ones you tolerate well, and how to build a balanced diet that strengthens your immune system instead of fighting against it.

2. Use vitamin C to lower histamine naturally — You might not realize that something as simple as vitamin C helps your body keep histamine in check. Studies show that just 300 to 500 milligrams (mg) of vitamin C a day enhances histamine degradation,4 while 2,000 mg daily lowers plasma histamine levels by about 40% within two weeks.5

That means fewer allergy symptoms without the brain fog Benadryl causes. The easiest way to get more vitamin C is through your plate — red peppers, citrus fruits, and kiwi are excellent choices. If your diet is lacking, a supplement at the right dose helps give you steady relief.

3. Lean on quercetin for long-term antihistamine support — Quercetin is a plant compound with powerful anti-allergy activity. It works by stabilizing the cells that release histamine, so your body doesn’t flood with it in the first place. Onions (especially the skins), apples, and berries are all rich in quercetin.

If you want a stronger effect, consider a supplemental dose of 500 mg to 1,000 mg, taken two to four times daily. If eating onion skins doesn’t sound appealing, making a broth from them is an easy workaround. Over time, this gives you steadier control of your allergy response without the rollercoaster sedation that comes with Benadryl.

4. Prioritize whole foods over processed snacks — Most allergy-prone people do not realize that processed food drives histamine issues. Packaged meals, boxed snacks, and fast food are loaded with additives that stress your system and reduce your resilience. Shifting toward fresh, whole foods — fruits, vegetables, grass fed beef, and root vegetables — gives your body the nutrients it needs to restore balance.

For instance, kaempferol — a potent anti-allergic flavonoid — is abundant in leafy green veggies, such as broccoli, spinach, and cabbage. This change doesn’t just help allergies; it also supports your energy, mood, and long-term health in ways no over-the-counter pill ever will.

5. Support your body with natural histamine balance strategies — Instead of relying on medications, you can strengthen your body’s own ability to manage histamine. While not a substitute for medical treatment in the case of severe allergies, simple daily habits make a big difference.

Focus on getting enough restorative sleep, since poor sleep increases inflammation and worsens allergy symptoms. Add regular movement — whether that’s walking, stretching, or gentle exercise — to help regulate immune function.

Make time for stress management, because high stress raises histamine release and intensifies allergic reactions. Even mindful practices like deep breathing or spending time outdoors in fresh air help calm your system. By making these lifestyle shifts, you create a foundation that keeps histamine under control naturally and reduces your reliance on drugs altogether.

FAQs About Benadryl

Q: Why is Benadryl considered unsafe today?
A: Benadryl, which contains diphenhydramine, was introduced in the 1940s but is now seen as outdated and risky. Research shows it causes strong sedation, confusion, memory issues, and even higher accident risk than alcohol. Long-term use is linked to dementia and other health problems, making it a poor choice compared to safer modern options.

Q: What makes diphenhydramine more dangerous for older adults and children?
A: Older adults metabolize the drug slowly, leaving them groggy and cognitively impaired for up to 18 hours. This raises their risk of falls, accidents, and memory decline. Children often react unpredictably, becoming hyperactive or agitated instead of sleepy. In overdose situations, toddlers face extreme sedation, coma, or even life-threatening heart problems.

Q: Are other countries limiting Benadryl’s availability?
A: Yes. Germany, Sweden, and the Netherlands have already restricted diphenhydramine to prescription-only status. In the U.S., agencies such as the FAA ban pilots from using sedating antihistamines, while pediatric guidelines in the U.S., Canada, and the U.K. advise against giving Benadryl products to young children.

Q: What natural remedies help manage histamine without using Benadryl?
A: You can lower histamine naturally by using vitamin C, which reduces histamine levels in your blood, and quercetin, which stabilizes the cells that release histamine. Whole foods rich in these compounds — such as red peppers, citrus fruits, onions, and berries — support your immune system and reduce allergy symptoms without sedating you.

Q: What lifestyle steps reduce allergy symptoms long-term?
A: Focusing on root causes makes the biggest difference. An elimination diet helps identify triggers without risking nutrient deficiencies. Prioritizing whole foods over processed snacks, getting restorative sleep, moving daily, and managing stress all support histamine balance. These changes strengthen your body’s resilience, keeping symptoms under control naturally and safely.

A New Series of Health Insights Is on the Way

VIKTIG

A New Series of Health Insights Is on the Way
Our team has been working behind the scenes to prepare new research and practical health strategies for our readers. While we finish preparing what’s coming next, we invite you to explore one of the most-read articles from our library below. See exactly what’s changing →

One of the most overlooked drivers of cardiovascular risk is vascular aging — where your arteries become stiff, inflamed, and less responsive over time. This process begins earlier than you might think and can progress silently for years before showing up as a heart attack, stroke or metabolic disease.

Vascular aging is marked by a loss of elasticity in your blood vessels, elevated oxidative stress, and declining endothelial function — the inner lining of your arteries that controls how well they expand and contract. When that function drops, blood flow suffers. You get less oxygen to your tissues and your risk of cardiovascular disease, dementia, and Type 2 diabetes increases dramatically.

Creatine isn’t the first thing that comes to mind when you’re thinking about vascular health. It’s usually associated with gym routines or athletic performance. But your body actually makes about 1 to 2 grams of creatine a day from amino acids — and this compound plays a central role in maintaining your cellular energy.

Creatine acts like a rechargeable battery for your cells, helping to rapidly regenerate adenosine triphosphate (ATP), your body’s energy currency, especially in high-demand areas like muscles, nerves, and blood vessels. The real breakthrough? Research shows creatine isn’t just for muscles — it also helps your blood vessels work better, keeps them flexible and improves how well oxygen reaches your tissues.

This matters if you’re over 50 or have blood sugar or weight issues, because stiff or weak blood vessels raise your risk for heart problems. Here’s what the latest research found about how creatine improved artery health and metabolism in older adults.

Creatine Helped Older Adults Improve Blood Flow in Just Four Weeks

A study in the journal Nutrients looked at how creatine affects the blood vessels of older adults who aren’t very active.1 For four weeks, participants took creatine every day. Then, after a short break, they switched to a placebo so researchers could compare the results.

• Creatine helped make arteries more flexible — After four weeks of creatine use, their arteries worked better. Specifically, their endothelial function improved, meaning their blood vessels could relax and open more easily during blood flow.

After taking creatine, flow-mediated dilation (FMD), which measures how much arteries expand when blood flow increases, improved from 7.68% to 8.9%. That sounds small, but even a 1% increase in FMD is linked to a 13% lower risk of heart problems.

• Oxygen delivery through small blood vessels improved too — In smaller vessels, oxygen delivery to tissues also got a big boost. This matters because better oxygen flow helps your muscles, brain, and organs recover, heal and perform more efficiently.

• Creatine lowered fasting blood sugar and triglycerides — After 28 days, the participants’ blood sugar dropped from prediabetic levels to a healthier range. Their triglycerides, which are fats in the blood linked to heart disease, also went down significantly. These changes happened without any other lifestyle changes — just from adding creatine.

Creatine’s Benefits Came from Real Biological Changes

Your body uses the amino acid arginine to make creatine — but it also uses arginine to produce nitric oxide (NO), a gas that helps relax and open your blood vessels. When you get creatine from supplements, your body doesn’t need to use as much arginine to make it. That means more arginine is available to support healthy blood flow.

• Energy delivery improved in the arteries — ATP is the main energy source for your cells. Creatine helps move ATP to the cells that need it most — especially muscle and blood vessel cells. When your arteries have enough energy, they stay flexible and responsive, which helps keep your circulation in balance.

• In small vessels, creatine supported potassium pumps that control flow — Small blood vessels don’t rely as much on nitric oxide. Instead, they depend on potassium ion pumps that need steady energy to work. These pumps open and close to regulate blood flow. Creatine helps power these pumps by supporting ATP levels, which helps explain why oxygen delivery improved so much.

• None of these effects happened with the placebo — The placebo group didn’t see any change in artery flexibility, oxygen flow, blood sugar, or triglycerides. That shows it was the creatine — not just the routine of taking something daily — that made the difference. No side effects were reported, and blood pressure, hydration, and kidney markers stayed stable throughout the study.

Creatine Made Arteries More Flexible in Just One Week

Adding support to creatine’s benefits, research published in Clinical Nutrition ESPEN looked at whether creatine could improve heart and blood vessel health in older men in just seven days.2 Unlike most studies that take weeks or months, this one tested short-term effects. The goal was to see if even a quick creatine boost could make a difference.

• Artery stiffness dropped in just seven days with creatine — The group taking creatine saw a drop in a test measuring how stiff or flexible your arteries are. It went from 8.7 to 8.2 — a meaningful improvement.

• Blood pressure started to trend lower, too — Although not statistically significant yet, systolic blood pressure (the top number) fell from 144 to 136.1 mmHg. That’s an eight-point drop in one week. If the trend continues, it could mean a lower risk of heart problems with ongoing use.

• Heart stress didn’t increase, which makes creatine a safe option — Unlike some interventions that rev up the heart, creatine didn’t change how hard the heart had to pump. That’s a key point for anyone managing early signs of cardiovascular problems. You want support without overstimulation, and creatine fits that profile.

How to Increase Your Creatine Intake and Support Vascular Health

If you’re looking to protect your heart as you age, adding creatine to your routine could be a smart move. But before you jump to supplements, it’s important to understand how to do this safely and in a way that supports your long-term health. I recommend starting with food first, then using supplements to fine-tune your levels if needed.

Your arteries and vascular system thrive when they’re well-fed with nutrients that support cellular energy. Creatine is one of the most effective nutrients for this job. Below, I’ve outlined five steps you can take to improve your creatine intake and support your cardiovascular system from the inside out.

1. Start with real food sources of creatine — Your body naturally makes some creatine on its own but not enough to meet higher demands — especially as you age. The most efficient way to get more creatine is by eating animal-based foods like grass fed beef. Avoid conventionally raised pork and chicken, as they’re loaded with linoleic acid (LA), which disrupts your cellular energy production and cancels out the benefits of creatine.

2. Consider supplements if you’re vegetarian or vegan — If you’re following a vegetarian or vegan diet, you’re not getting creatine from your food, as it doesn’t exist in plants. That means you’re relying entirely on what your body can make, and that might not be enough to support your vascular health. If you don’t consume animal-based foods, it would be wise to reevaluate your dietary approach or consider targeted supplementation.

3. Use creatine monohydrate if you need a supplement — If you’re not able to get enough creatine from food, or you’re aiming to reach the recommended daily dose of 3 to 5 grams per day, I recommend creatine monohydrate. It’s the most studied and safest form. Choose a clean product from a trusted company — no additives, fillers or mystery flavors.

4. Stick with the proven dose to avoid side effects — More isn’t better when it comes to creatine. The sweet spot for most adults is 3 to 5 grams per day. Go higher than that — especially up to 10 or 20 grams — and you’re more likely to deal with bloating, water retention, or loose stools.

5. Support creatine’s effects by reducing LA in your diet — If your diet is high in LA — found in vegetable oils like soybean oil, corn oil, and safflower oil — your cells can’t produce energy efficiently. That’s why I advise removing these unhealthy fats from your diet. Switch to tallow, ghee, or grass fed butter. Cut out packaged snacks, fried foods and most restaurant meals unless you know exactly how they’re prepared. Your arteries will thank you.

Making these changes isn’t about perfection. It’s about giving your cells what they need to function at their best. Start where you are, make one upgrade at a time and pay attention to how your body responds. That’s how you take control of your vascular health — without waiting for symptoms to show up.

FAQs About Creatine

Q: What does creatine do for your heart and blood vessels?
A: Creatine improves how well your arteries expand and contract, which boosts blood flow and reduces the workload on your heart. It also enhances oxygen delivery to your tissues and supports better circulation overall.

Q: How quickly does creatine improve vascular health?
A: Improvements have been seen in as little as seven days. One study found creatine made arteries less stiff in just seven days, while another saw better artery flexibility and oxygen flow after four weeks of daily use.

Q: Can creatine help with blood sugar or triglycerides?
A: Yes. In one study, fasting glucose dropped from prediabetic to normal levels, and triglycerides significantly decreased, both of which are key risk factors for heart disease.

Q: Does creatine help even if you don’t exercise?
A: Yes. One study focused on older adults who were mostly sedentary, and they still saw improvements in blood flow, artery flexibility and metabolic markers like blood sugar and triglycerides. This shows creatine supports vascular health even without changes to your workout routine.

Q: What’s the best way to add creatine to your routine?
A: Start with whole food sources like grass fed beef. If needed, supplement with creatine monohydrate — choose a clean product without fillers.

A New Series of Health Insights Is on the Way

VIKTIG

A New Series of Health Insights Is on the Way
Our team has been working behind the scenes to prepare new research and practical health strategies for our readers. While we finish preparing what’s coming next, we invite you to explore one of the most-read articles from our library below. See exactly what’s changing →

Tinnitus is the perception of sound — often ringing, buzzing, or clicking — without any external source. It’s not just annoying; it’s also debilitating. Common symptoms include persistent phantom noise in one or both ears, sleep disturbances, anxiety, and difficulty concentrating.

Over time, if ignored, tinnitus will fuel depression, increase stress hormones, and severely impact your quality of life. The global prevalence now hovers around 14.4% in adults and 13.6% in children,1 with some estimates even higher in specific populations. Despite its growing impact, most people are still told there’s no known cause, and worse, no effective treatment.

However, recent studies provide a practical insight into tinnitus prevention — simply including certain nutrient-dense foods in your meals will help influence nerve health and blood flow, reducing its symptoms.

A Large Meta-Analysis Identified Dietary Patterns Linked to Tinnitus Risk

A systematic review and meta-analysis published in BMJ Open2 brought together data from over 301,533 adults across eight observational studies. Using validated questionnaires,3 the research team set out to assess 15 dietary factors that influence the likelihood of developing tinnitus. Their focus was not on supplements or isolated nutrients, but on actual food intake patterns in everyday life.

• Four specific foods had protective effects — Adults 18 and older were included regardless of whether they had pre-existing health issues. Of the 15 dietary factors analyzed — like sugar, fat, meat, and vegetables — only four stood out as protective — fruit, fiber, dairy, and caffeine.

• Fruit offered statistically significant protection against tinnitus — Fruit intake had the most dramatic effect, reducing tinnitus odds by 35%, making it the most powerful dietary variable in the entire analysis. The odds ratio for fruit was 0.649, showing a strong inverse relationship between fruit intake and tinnitus risk.

• No notable link was seen between tinnitus prevention and vegetables — Surprisingly, vegetables didn’t have the same consistent benefit, highlighting fruit as the better choice for prevention.

• These effects held up across diverse global populations — The studies included participants from the U.K. Biobank and Australia’s Blue Mountains Hearing Study, making the results more applicable to a wide population.

Why Do Fruits Offer Protective Effects Against Tinnitus?

The researchers conducted sensitivity analysis — where one study is removed to see if results change — to gather more robust results. These tests showed that the protective effects of fruit and fiber remained steady. Other foods, including sugar, meat, and even diet variety, failed to show a consistent protective link.

This was likely due to inconsistencies in measurement or how the foods were prepared and consumed. The researchers outlined three primary biological mechanisms to explain fruit’s benefits, mainly:

• Fruits offer impressive antioxidants effects — Fruits are loaded with antioxidants like vitamin C, polyphenols, and carotenoids. These nutrients fight oxidative stress, which is one of the key drivers of cellular damage in the cochlea — the part of your inner ear responsible for hearing.

• They improve blood flow to auditory structures — Fruit promotes vascular health and enhances endothelial function, which is the ability of blood vessels to relax and contract. This improves circulation, which ensures sensitive structures in the inner ear get the oxygen and nutrients they need. Poor circulation is known to contribute to tinnitus symptoms over time.

• Eating fruit reduces chronic inflammation in nerve pathways — The anti-inflammatory effects of flavonoids like quercetin protect auditory nerves from overstimulation. This helps keep neural signaling steady, reducing the kind of faulty signals that cause ringing or buzzing in the ears. Inflammation interferes with normal nerve firing and amplifies sensory perception, both of which worsen tinnitus.

Dairy, Fiber, and Caffeine Also Provided Benefits Against Tinnitus

One of the most surprising findings was that avoiding dairy actually increased tinnitus risk. While some conventional advice recommends avoiding dairy products like cheese and butter4 if you have tinnitus, the data in this review suggested consuming these foods supports auditory health.

• Consuming dairy reduced the risk of tinnitus by 17% — It improved vascular tone and supported the same endothelial functions that fruit did. The type of dairy wasn’t specified, but the implication was that unprocessed or minimally processed dairy offers support, while highly processed versions might not.

• Consuming fiber was associated with 9% lower risk — It improved insulin sensitivity and blood vessel health, which are two major systems tied to how the inner ear functions.

• Fiber improved insulin balance, which impacts inner ear fluid pressure — The benefit of fiber was tied to better blood sugar regulation. When insulin sensitivity is low, excess insulin circulates in the bloodstream, which disrupts fluid and electrolyte balance in the ear. That destabilization affects how sound is transmitted and processed, which worsen tinnitus if left uncorrected.

• Moderate caffeine intake reduced tinnitus risk by 10% — The idea that caffeine worsens tinnitus is still common, but this analysis disproved it. Contrary to outdated advice, consuming caffeine in moderation improves alertness, boosts dopamine, and increases blood flow — all of which support auditory processing. It also blocks adenosine receptors, which help reduce inflammation in brain areas involved in sound perception.

The authors recognize that they cannot completely confirm the causality due to the observational design of the included studies. They also note that conducting further large-scale studies will “complement and verify the relationship between dietary intake and tinnitus.”5,6

Butter and Legumes Were Both Linked to Reduced Tinnitus Severity

A similar study published in Nutrients7 surveyed over 11,000 adults with tinnitus to assess how different food choices relate to how severe their symptoms feel. The researchers focused on how loud, constant, or intrusive the symptoms were depending on your dietary habits.

The study analyzed more than 50 dietary variables using a large pool of participants with varying backgrounds. This made the results more reflective of how diet influences tinnitus in everyday life. Two examples of dietary factors they looked at include dairy — specifically butter — and legumes.

• Butter intake was linked to less tinnitus severity — Just like the BMJ Open study, this study also found that dairy has protective effects against tinnitus. Contrary to some mainstream beliefs about avoiding saturated fat, the study showed that people who used butter regularly experienced lower tinnitus severity.

According to the researchers, “Those who reported a normal or high use of butter had a significantly reduced risk of tinnitus onset (compared to those who do not use butter).”8 This protective link suggests butter helps support auditory function.

• Legumes also reduced the severity of symptoms — People who regularly consumed legumes (beans, lentils, or chickpeas) reported milder tinnitus, the researchers reported. Legumes were associated with calmer symptoms, which could be explained by their high content of magnesium, fiber, and B vitamins. These nutrients support vascular health and stabilize nerves, two key areas that affect how the brain processes sound.

• Legumes help balance blood sugar and calm inflammation — The research team emphasized the connection between blood sugar regulation and inner ear function. Legumes help stabilize glucose and improve insulin sensitivity, which reduces inflammation. Better blood sugar control helps reduce the kind of fluid and nerve imbalances that make tinnitus worse.

The takeaway isn’t just about “eating healthy” — it’s about eating smart. The key is to identify foods that calm your nervous system and improve blood flow, and both butter and legumes show promise in this, in different but complementary ways. Adding them to your diet will support better outcomes when dealing with tinnitus.

These Artificial Ingredients Trigger Nerve Overload That Make Tinnitus Worse

Eating the right types of foods is beneficial, but what you DON’T eat matters, too. In particular, chemical additives like monosodium glutamate (MSG) and the artificial sweetener aspartame were found to contribute to tinnitus symptoms.9 These additives act as excitotoxins, meaning they overstimulate your nerve cells until they’re damaged or die. This mechanism also fuels nerve dysfunction that causes or worsens tinnitus.

• MSG overstimulates glutamate receptors in the auditory system — Widely used in fast food, instant noodles, chips, and restaurant meals to enhance flavor, MSG works by exciting glutamate receptors in the brain. These same receptors are found in the auditory system.10 According to research,11 people who have tinnitus have high levels of glutamate, which leads to hyperexcitability in their auditory cortex.

• Aspartame breaks down into chemicals that overexcite the brain — When ingested, aspartame (a sweetener found in diet sodas and sugar-free foods) converts in the body into three compounds — aspartic acid, which produces aspartate, a highly stimulating neurotransmitter; the amino acid phenylalanine; and methanol, or wood alcohol.12

• Aspartate damages neurons in the brain — It disrupts normal neurotransmitter balance and creates chaos in the brain’s sound-processing centers. This amplifies tinnitus symptoms and lead to heightened perception of noise that isn’t really there.

• Both additives gradually worsen tinnitus by overstimulating nerve cells — The effects of MSG and aspartame build quietly over time. You might not notice their effects after one meal, but repeated exposure continues to overstimulate the auditory nerves. If you’re already dealing with tinnitus, this overstimulation will turn manageable noise into a constant, distressing hum that gets harder to ignore.

• MSG and aspartame cross your blood-brain barrier — These chemicals lead to cellular stress and eventual nerve damage. This not only worsens ringing but also increases the risk of long-term hearing dysfunction.

The solution — eat clean and check food labels carefully. Removing these toxic chemicals from your diet will make an immense difference between constant suffering and much-needed silence.

Eat More Whole Foods and Avoid Processed Foods

Based on these studies, it’s clear that the root cause of tinnitus isn’t just aging or random nerve damage — it’s overstimulation of your nervous system, blood sugar instability, inflammation, and poor circulation in your inner ear. The wrong foods worsen the symptoms, and right ones help curb them. Here are five dietary strategies to help you cope with tinnitus.

1. Cut out aspartame, MSG, and other excitotoxins immediately — If you’re still drinking diet sodas, chewing sugar-free gum, or eating foods labeled with “autolyzed yeast,” “hydrolyzed protein,” or “natural flavors,” you’re feeding the very system that’s making your tinnitus worse. Remove them from your kitchen and don’t look back. Most people feel relief in less than a week when they stop.

2. Eat more fruit — especially high-antioxidant, water-rich varieties — Fruit helps reduce oxidative stress, improves microcirculation in the cochlea, and supports your nerve function. Start slow with easy-to-digest options like watermelon, oranges with pulp, or ripe papaya. Aim for at least two to three servings a day, and space them out to stabilize blood sugar.

3. Use real butter, not seed oils or margarine — If you’ve been using vegetable oils (like canola and soy oil) or butter substitutes thinking they’re healthier, it’s time to reverse that.

4. Add legumes like lentils or chickpeas three to four times per week — If you are sensitive to fiber or deal with gas and bloating, try pressure-cooked lentils or soaked split mung beans to start. These are easier on your gut and still deliver the same auditory and neurological benefits. You don’t need a huge portion — just a small bowl alongside your meal is enough.

One drawback when consuming legumes is they contain lectins, which are sugar-binding plant proteins that can have adverse effects. You can sidestep this issue by preparing and cooking legumes properly to reduce their lectin content. Read “How to Reduce Lectins in Your Diet” for more detailed instructions.

5. Drink caffeine in moderation — Moderate daily intake, like one strong coffee or a couple cups of green tea, will help reduced tinnitus severity. However, too much caffeine could backfire, especially if it triggers anxiety or insomnia for you.

Your symptoms are giving you clues. The trick is learning to listen to what your body is asking for — then feeding it the calm, stabilizing foods that keep the volume down.

Remember These Tips to Protect Your Hearing

Protecting yourself from loud noises is the first step in preventing both tinnitus and hearing loss. Follow these basic strategies:

• Turn down the volume on personal audio devices.
• Download a decibel meter app for your smartphone, which will flash a warning if the volume is turned up to a damaging level.
• Wear earplugs when you visit noisy venues. If you work in a noisy environment, be sure to wear ear protection at all times.
• Use carefully fitted noise-canceling earphones/headphones, which allows you to listen comfortably at a lower volume.
• Limit the amount of time you spend engaged in noisy activities.
• Take regular listening breaks when using personal audio devices.
• Restrict the daily use of personal audio devices to less than one hour.
• If you live in a very noisy area, consider moving. If this is not an option, consider adding acoustical tile to your ceiling and walls to buffer noise. Double-paneled windows, insulation, heavy curtains and rugs also help reduce noise volume.
• Use sound-blocking headphones to eliminate occasional sound disturbances such as that from traffic or lawnmowers. Wear ear protection when using your lawnmower or leaf blower.
• Improve your sleep quality. Sleep interruptions and poor sleep quality worsen tinnitus symptoms, creating a sleeping environment that supports uninterrupted and restorative rest is essential. To learn more about this, read “The Hidden Impact of Napping on Tinnitus.”

In addition, I recommend addressing your nutrient deficiencies, as certain ones increase your risk. Magnesium deficiency is one example; studies have demonstrated that supplementing with magnesium helped improve hearing in participants who suffer from tinnitus or hearing loss.13 For more examples of nutrients that impact tinnitus and hearing loss, read “Can Magnesium Relieve Your Tinnitus?”

Frequently Asked Questions (FAQs) About How Foods Affect Tinnitus

Q: What foods are most effective at lowering the risk of developing tinnitus?
A: Fruit is the standout performer, with one large meta-analysis showing a 35% reduced risk for those who eat more of it. Fiber, dairy, and caffeine also had protective effects — each improving nerve function, blood flow, or inflammation control in the auditory system.

Q: Do certain foods reduce the severity of existing tinnitus symptoms?
A: Yes. A separate study of over 11,000 adults found that those who consumed butter and legumes regularly experienced less severe tinnitus. These foods support vascular health, stabilize nerves, and improve blood sugar balance — key factors in calming auditory symptoms.

Q: What ingredients or additives should I avoid if I have tinnitus?
A: You should eliminate MSG and aspartame immediately. These additives overstimulate your nerve cells, especially those involved in hearing, and worsen tinnitus over time. They’re often hidden in processed foods, diet drinks, seasonings, and low-calorie snacks.

Q: Is caffeine safe for people with tinnitus, or does it make it worse?
A: Contrary to common advice, moderate caffeine intake actually helps. Studies show it reduces tinnitus risk by around 10%, likely due to its effects on circulation, dopamine, and inflammation. The key is moderation — not elimination or excess.

Q: What are the best daily strategies for managing tinnitus through diet?
A: Start by eating more fruit, legumes, and whole foods, using real butter instead of seed oils. Eliminate excitotoxins like MSG and aspartame, and drink caffeine in controlled amounts. These changes target the actual root causes — nerve overstimulation, inflammation, and poor circulation.

Most people assume antibiotics do their job and leave no trace — a short course, a quick recovery, and life goes on. But emerging research tells a very different story. A large-scale study published in Nature Medicine reveals that a single course of antibiotics leaves a measurable imprint on your gut microbiome that persists for years, not weeks.1

Your gut microbiome, the trillions of bacteria lining your digestive tract, doesn’t just help you digest food. It plays a role in metabolic regulation, immune development, and processes ranging from inflammation to blood sugar control.
When that system gets disrupted, the consequences ripple outward in ways many people don’t connect back to the prescription they took years earlier: changes in how you process food, how your body manages inflammation, and how well your immune system holds up under pressure.

The findings challenge a basic assumption that your body simply bounces back. Below, I walk through what the research actually shows, which antibiotics do the most damage, and what you can do to limit the fallout and rebuild.

Antibiotics Leave a Long-Term Imprint on Your Gut

The Nature Medicine study analyzed data from 14,979 adults in Sweden to understand how antibiotic use affects the gut microbiome over time.2 Researchers combined prescription records with advanced stool analysis to measure changes in gut bacteria across an eight-year period. This gave them a long-term view of what actually happens after you take antibiotics — not just days or weeks later, but years down the line.

The study included adults from multiple population-based cohorts and examined their antibiotic exposure in three timeframes: less than one year, one to four years, and four to eight years before testing. Across all groups, antibiotic use consistently linked to lower diversity of gut bacteria.

That means fewer types of beneficial microbes, a key marker tied to resilience, digestion, and metabolic stability. Every additional antibiotic prescription was associated with a measurable drop in microbiome diversity, with the biggest decline occurring after the first and second courses.

• Some antibiotics cause deeper damage than others — Not all drugs affected the gut equally. Clindamycin, fluoroquinolones, and flucloxacillin had the strongest and most widespread impact, reducing dozens of bacterial species per course. For example, one round of clindamycin within a year of testing was linked to an average loss of 47 bacterial species. In contrast, more commonly used antibiotics like penicillin V showed far fewer long-term effects.

• Changes persist long after the prescription ends — Even when antibiotics were taken four to eight years before testing, researchers still detected significant differences in gut bacteria composition. Between 10% and 15% of microbial species remained altered years later.

This means your gut doesn’t simply bounce back to baseline — it shifts into a new compositional state that may function differently. When researchers looked at people who had taken only one antibiotic course in eight years, they still found reduced diversity compared to those who had taken none.

• Certain bacterial species increase while beneficial ones decline — Antibiotics often reduced helpful bacteria while allowing less favorable species to grow. Some of these shifts were linked to bacteria associated with higher body weight, inflammation, and metabolic imbalance. These compositional shifts may affect how efficiently the gut environment functions when imbalances persist.

• Your gut ecosystem works like a complex community — Think of your microbiome as a crowded city where each species has a role. Antibiotics act like a sudden evacuation — removing both helpful and harmful residents at once. When the system rebuilds, the same balance doesn’t always return. Some key “workers” don’t come back, and new ones move in that don’t perform the same jobs.

Antibiotic Damage Slows Gut Recovery and May Affect Broader Health

While your gut begins recovering soon after antibiotic exposure, the study revealed that recovery slows significantly over time.3 Most of the rebound happens in the first two years, after which progress becomes much slower. This explains why long-term differences remain detectable even eight years later.

• The size of the initial disruption determines recovery time — A deeper initial drop in bacterial diversity was associated with a longer recovery period. Stronger or broader-spectrum antibiotics create a larger “shock” to your gut, and that shock takes longer to repair. This helps explain why certain medications leave a more lasting imprint than others.

• Antibiotics disrupt both balance and function in the gut — From a biological standpoint, antibiotics alter how your system works. Beneficial bacteria thought to play roles in digestion, inflammation regulation, and gut-lining maintenance decrease, while other species fill the gaps. Researchers speculate that this shift may influence nutrient absorption and how your body handles everyday stressors — though these downstream effects were not directly measured in the featured study.

• Lower diversity weakens your body’s internal defenses — When diversity drops, the gut may have a reduced capacity to keep harmful bacteria in check and maintain stability. This shift has been associated with a greater likelihood of inflammation and metabolic changes. Over time, these internal changes may be linked to how the body manages blood sugar, fat storage, and immune responses.

• Antibiotics reshape microbial signaling throughout your body — Your gut bacteria communicate with your immune system and metabolic pathways through chemical signals. When antibiotics change the composition of those bacteria, they also change those signals. This may affect processes like inflammation signaling and energy use, which could help explain the broader associations observed between gut disruption and health.

How to Limit Antibiotic Damage and Rebuild Your Gut

Understanding the damage is only useful if it points you toward what actually helps your gut recover. Microbial diversity often does not fully rebuild on its own, and dietary inputs may play an important role in supporting recovery. Your gut bacteria need specific raw materials from food to recolonize and regain their functional roles.

Different species thrive on different substrates — fibers, polyphenols, and resistant starches — which is why dietary variety matters as much as dietary quality. At the same time, foods associated with inflammation or gut-barrier stress may slow that process, creating an environment where the wrong species gain ground while beneficial ones struggle to return. That’s the logic behind every step that follows: remove what interferes with recovery, then supply what your bacteria need to rebuild.

1. Use antibiotics only when they’re truly necessary — If you reach for antibiotics every time you get a cough, sore throat, or sinus flare, pause before you do that again. Many of those illnesses are viral, and antibiotics do nothing for viruses. What they do accomplish is another blow to your gut ecosystem. Your first step is to treat antibiotics as a last resort, not a reflex. That single shift helps preserve bacterial species that contribute to digestion, inflammation balance, and recovery.

2. Cut off the background exposure from conventional meat — If your meals rely on cheap fast-food meat, grocery store deli meat, or conventionally raised chicken, pork, or beef, your gut faces a steady trickle of antibiotic residues from that food supply. To reduce your exposure, choose pasture-raised or organic meats so your microbiome isn’t subjected to low-dose antibiotic exposure day after day.

3. Use natural antibacterial options for mild problems — For mild issues, natural antibacterial options like medicinal honey and oregano oil have been explored as alternatives for mild issues, with less impact on microbial balance. These may offer an alternative approach for minor issues when antibiotics aren’t medically necessary.
That matters because every time you avoid an unnecessary antibiotic, you preserve more of the bacterial species your gut needs. Think of it as protecting your internal reserves instead of draining them again.

It’s also worth remembering what I believe is the best way to ease upper respiratory infections (URIs) — nebulized hydrogen peroxide. Many make the mistake of taking antibiotics for URIs unnecessarily, but because most URIs are viral, antibiotics typically aren’t effective for these cases.

4. Remove the foods and fats that keep your gut barrier irritated — Your gut doesn’t recover well on ultraprocessed food, refined snacks, and seed oils high in linoleic acid (LA). Your gut lining depends on healthy, stable cell membranes to repair itself after antibiotic damage, and the fats you eat directly shape those membranes.

Excessive LA intake alters cellular membranes and interferes with mitochondrial function. So, if your pantry is full of chips, packaged grain products, frozen meals, and restaurant food cooked in soybean, corn, canola, or sunflower oil, start there. Replace those foods with simple meals cooked in grass fed butter, ghee, or tallow.

Your goal is to lower LA intake below 5 grams a day, and closer to 2 grams if possible. Typical meals might include pastured eggs cooked in butter, white rice with slow-cooked grass-fed beef, and whole fruit. That gives your gut lining stable fuel instead of more disruption.

5. Rebuild your carb and fiber tolerance in the right order — If your digestion is already struggling — bloating, post-meal fatigue, unpredictable bowel habits — loading up on fiber is likely to make things worse before they get better. The goal of this rebuilding process is to help your gut bacteria produce butyrate, a short-chain fatty acid that serves as a key fuel source for the cells lining your colon.

Without enough butyrate, those cells can weaken, your gut barrier may become more permeable, and inflammation may spread more easily into the rest of your body. But your bacteria can only make butyrate when they have the right raw materials — and that means reintroducing fiber in a sequence your gut can handle. Start with easy-to-digest foods such as whole fruit and white rice, so your body gets the glucose it needs for cellular energy.

Once your digestion settles, add fiber slowly: root vegetables first, then non-starchy vegetables, then starchier plants like squash or sweet potatoes. Later, if you tolerate them well, add beans, legumes, and minimally processed whole grains.

FAQs About Antibiotics and Your Gut Microbiome

Q: How long do antibiotics affect my gut microbiome?
A: Research shows that changes in your gut microbiome remain detectable up to eight years after a single course. While some recovery happens in the first two years, your gut may take much longer to return to its original state, if it does so at all. In other words, the compositional effects of a single prescription can persist for years, with possible downstream influence on digestion, metabolism, and immune function.

Q: Do all antibiotics damage my gut the same way?
A: Different antibiotics create very different levels of disruption. Drugs like clindamycin, fluoroquinolones, and flucloxacillin were associated with the most significant and long-lasting changes, reducing dozens of bacterial species at once. More commonly used antibiotics like penicillin V have a smaller impact. The broader and stronger the antibiotic, the deeper the disruption inside your gut.

Q: Can my gut fully recover after taking antibiotics?
A: Your gut begins recovering soon after antibiotic use, but that recovery slows dramatically over time. Most of the improvement happens within the first two years, then progress becomes much slower. Some bacterial species don’t return, which means your microbiome shifts into a new balance rather than fully restoring what was there before.

Q: Why does gut bacteria diversity matter for my health?
A: Gut diversity acts like a built-in defense system. Having a wider range of beneficial bacteria may support digestion, inflammation regulation, and immune resilience. When diversity drops, harmful bacteria gain an advantage. This imbalance is linked to weight gain, inflammation, blood sugar issues, and a higher risk of chronic disease.

Q: What steps help protect and rebuild my gut after antibiotics?
A: One key strategy is to limit unnecessary antibiotic use so your gut stops taking repeated hits. From there, reducing hidden exposure from conventional meat, choosing simple whole foods, removing seed oils, and rebuilding carbohydrate and fiber tolerance step by step all support recovery. These changes may support microbial balance, gut-lining integrity, and cellular energy production.

Test Your Knowledge with Today’s Quiz!
Take today’s quiz to see how much you’ve learned from yesterday’s Mercola.com article.

Which intervention has been shown to reduce fatigue in people with long COVID?

Electrolyte-rich drinks
Hydrogen-rich water
Hydrogen-rich water improved fatigue, strength, walking distance, and sleep by supporting cellular energy production, which is often impaired in long COVID. Learn more.
High-dose vitamin C
Protein supplements

A New Series of Health Insights Is on the Way

VIKTIG

A New Series of Health Insights Is on the Way
Our team has been working behind the scenes to prepare new research and practical health strategies for our readers. While we finish preparing what’s coming next, we invite you to explore one of the most-read articles from our library below. See exactly what’s changing →

Arthritis doesn’t have to define your days. If you’re living with stiff, painful joints, there’s hope beyond prescriptions and over-the-counter creams. You can take charge of your wellness starting today with tools from nature that work alongside your regular care.

Essential oils, concentrated plant extracts with powerful anti-inflammatory properties, offer welcome relief. In just a few weeks, you could start feeling better naturally. Here’s how to make essential oils part of your daily routine and support your joints the holistic way.

Decode the Pain to Take Back Control

About 53.2 million Americans live with arthritis.1 That means you’re not alone if you’re dealing with joint pain, stiffness, or swelling. The two most common types are osteoarthritis and rheumatoid arthritis. Both cause discomfort, but in different ways.

• Osteoarthritis is like the tread wearing off your tires — Over time, the cushioning between your joints — called cartilage — breaks down. This leads to bones rubbing together, which causes pain and stiffness.

• Rheumatoid arthritis is different — It’s an autoimmune condition, which means your immune system mistakenly attacks your own joints. It causes swelling, fatigue, and joint damage if left untreated.

• A villain in both types is inflammation — Your body uses inflammation to heal, like when you get a cut. But with arthritis, it becomes chronic — like a fire alarm that won’t stop ringing. This ongoing inflammation leads to more damage and more pain.

That’s where essential oils come in. Many contain natural compounds that reduce inflammation and relieve pain. They don’t replace medical treatments, but they help you feel better and support your overall joint health.

Nature’s Toolkit to Calm Inflammation and Soothe Pain

You have options when it comes to natural support. Here are seven essential oils that help ease arthritis symptoms:2

1. Ginger — The natural painkiller — Ginger oil works like nature’s ibuprofen. In a study from the University of Miami, people with knee arthritis who used ginger extract reported significantly less pain and stiffness.3 Ginger helps block the same pain pathways that common pain relievers target — but without the harsh side effects.

2. Lavender — Relax and release tension — Lavender oil isn’t just for stress. It helps soothe joint pain and relax your muscles. Studies show that people with arthritis who received lavender aromatherapy massages felt better and moved more easily.4 Bonus: It helps ease anxiety and improve sleep, which often suffer when you’re in pain.

3. Frankincense — Ancient relief with modern science — Used for thousands of years, frankincense oil helps slow joint damage. Research suggests it blocks certain chemicals that break down cartilage and trigger swelling.5 Think of it as a shield for your joints.

4. Peppermint — Cooling comfort on contact — That icy-hot feeling you get from peppermint? That’s menthol at work. It creates a cooling sensation that numbs pain. Peppermint oil often works even better when blended with other oils like lavender or rosemary.

5. Turmeric — Spice that fights inflammation — Turmeric oil contains curcumin, a powerful anti-inflammatory. One review found it works as well as over-the-counter medications for arthritis relief.6 While most studies use turmeric extract, early research on the oil looks promising.

6. Eucalyptus — Breathe in the relief — Eucalyptus oil has a fresh scent and strong anti-inflammatory properties. A study found that people with rheumatoid arthritis had less pain and improved quality of life after inhaling eucalyptus oil.7

7. Rosemary — Flow and function — Rosemary oil may help numb nerves and improve blood flow. Better circulation means more nutrients reach your joints, which helps with healing and comfort.

Your Step-by-Step Guide to Natural Pain Relief

Using essential oils the right way makes all the difference. Here’s how to start safely:

• Step 1 — Dilute your oils — Essential oils are super concentrated, so don’t use them straight from the bottle. Mix a few drops with a carrier oil, like coconut oil. You need a natural base to blend it all safely.

• Step 2 — Choose your application — There are a few ways to use essential oils for arthritis:

◦Massage — Rub diluted oils directly onto sore joints.
◦Aromatherapy — Inhale oils using a diffuser or steam.
◦Bath — Add a few drops to Epsom salts for a warm, soothing soak.

• Step 3 — Use regularly for best results — Try applying essential oils twice a day — once in the morning and once before bed. Consistency matters. Some people experience relief relatively quickly, within a few days to a week of consistent use, especially with topical application for localized pain.

This initial relief could be due to the anti-inflammatory or pain-relieving properties of certain oils. For more significant and lasting relief, it might take several weeks of consistent and proper use.

• Step 4 — Do a patch test — Before using a new oil, test it on a small area of skin. Wait 24 hours to make sure there’s no redness or irritation.8

Small Steps, Lasting Relief — One Week at a Time

Follow this four-week plan to build a natural pain relief routine for arthritis using essential oils:

• Week 1 — Prep and patch test

◦Pick two to three oils to try, such as ginger, lavender, and frankincense.
◦Buy organic, therapeutic-grade products.
◦Test them on your skin and practice mixing with carrier oils.

• Week 2 — Start daily massage and inhalation

◦Apply your oils in the morning and evening.
◦Use a diffuser during rest or meditation time.
◦Keep a daily log — Track your stiffness, pain levels, and mobility.

• Week 3 — Add a soothing bath or compress

◦Add lavender or peppermint oil to your bath.
◦Try a warm compress with diluted oil on sore joints.
◦Alternate hot and cold packs for added relief.

• Week 4 — Review and adjust

◦Look back at your journal. What’s improving?
◦Change up your oils or add a third application.
◦Celebrate improvements — even small ones like waking up with less stiffness.

Combine Oils for More Powerful Results

Some oils work better together. Here are blends that may offer more relief:

• Lavender-clary sage-marjoram — This mix helps reduce both pain and stress. Use it at night to relax your body and mind.

• Ginger-turmeric-frankincense — This trio goes deep on inflammation. Use during flare-ups or days with extra stiffness.

• Eucalyptus-rosemary — This daytime blend helps with swelling and improves blood flow.

Remember, everyone’s arthritis is different, so customize your essential oils to meet your needs. Some people feel sharp, stabbing pain. Others feel dull, aching joints. Pick oils that match your main issues:

• Sharp pain — Try peppermint or tea tree.
• Aching or stiffness — Try rose, bergamot or myrrh.

You don’t need to change your whole life to start feeling better. Just add a few drops of nature into your routine. Essential oils offer a safe, supportive way to manage arthritis symptoms. Start with one or two oils, use them regularly and watch what changes.

Track your results. Adjust what’s working and what’s not. You’re not just treating symptoms — you’re taking back control of your health, one drop at a time. Ready to get started? Grab your favorite oils and take that first step today.

FAQs About Essential Oils for Arthritis

Q: What are the best essential oils for arthritis?
A: Top oils include ginger, lavender, frankincense, turmeric, eucalyptus, peppermint, and rosemary. These oils have anti-inflammatory and pain-relieving properties that help ease discomfort and support joint function.

Q: How long does it take to see results?
A: Many users feel less pain and stiffness after two to four weeks of daily use. However, everyone is different, so keep track of your progress and adjust as needed for your body.

Q: Can essential oils reduce inflammation?
A: Yes, many essential oils like turmeric, frankincense, and ginger contain compounds that have been shown in studies to reduce inflammation markers. These oils help calm your body’s inflammatory response and ease chronic swelling in joints.

Q: What’s the safest way to use essential oils?
A: Dilute with a carrier oil, do a patch test, and apply topically or use in aromatherapy. Avoid applying undiluted oils directly to your skin and don’t ingest them unless directed by a trained professional.

Q: Are there side effects of essential oils?
A: Some people have skin reactions or allergies. That’s why a patch test is important. If you notice irritation or any unusual symptoms, stop using the oil and consult your health care provider.

In a 14-day pilot, single-blind randomized controlled trial of 32 adults published in Nutrients, hydrogen-rich water was associated with reduced fatigue scores and improved walking distance, strength, and sleep quality in people with long COVID.1 Fatigue is widely understood as a sign that cells are not producing energy as efficiently as they could. When that system falters, even simple tasks like walking across a room or focusing on a conversation can become exhausting.

For those unfamiliar, long COVID is characterized by persistent fatigue, shortness of breath, poor sleep, and reduced physical capacity that continue for weeks or months after the initial infection clears. This means your body doesn’t fully recover, even when standard tests show nothing wrong. Many people also experience brain fog, muscle weakness, and disrupted daily function, which makes work, exercise, and basic routines harder to maintain.

What drives long COVID isn’t a single issue but a cascade of problems. Chronic inflammation, oxidative stress, and immune dysfunction keep your system in a constant state of strain. At the same time, your mitochondria — the parts of your cells responsible for producing energy — lose efficiency. That combination creates a cycle where low energy leads to inactivity, which further weakens your physical and metabolic capacity.

Against that backdrop, researchers began testing whether molecular hydrogen could interrupt this cycle at its root by reducing oxidative stress and restoring cellular function. The results point to a targeted way to improve energy, strength, and recovery, which sets up a closer look at exactly what the study uncovered and how those changes showed up in real people.

What the Trial Found: Hydrogen Water and Long-COVID Symptoms

In the featured Nutrients study, one group drank hydrogen-infused water and another drank regular water for 14 consecutive days, twice daily.2 The trial framework was single-blind, meaning participants did not know which water they received. This reduces participant expectation effects, though researchers were aware of group assignments and a small pilot cannot rule out all sources of bias.

The study included 32 adults who continued to experience fatigue and shortness of breath weeks after their COVID infection. These individuals had measurable declines in daily function, including reduced endurance, muscle weakness, and poor sleep quality. By focusing on people already dealing with lingering symptoms, the researchers tested whether hydrogen water could produce real-world improvements that you would actually feel in your day-to-day life.

• Fatigue dropped noticeably compared to placebo — The group drinking hydrogen-rich water showed a statistically significant reduction in fatigue scores compared to the placebo group. Participants in the hydrogen group reported feeling less exhausted and more capable of handling daily activities. The effect size was classified as moderate, meaning the change was strong enough to matter in real life, not just on paper.
• Physical endurance improved in measurable ways — One of the clearest results came from the six-minute walk test, which measures how far someone can walk in a fixed time.
Participants drinking hydrogen water increased their walking distance significantly more than the placebo group, with improvements ranging between about 42 to 62 additional meters (roughly 138 to 203 feet). Within the trial, this magnitude of improvement reflects gains in cardiovascular and muscular endurance among the studied participants; whether comparable gains generalize beyond this population requires larger trials.
While hydrogen water produced measurable gains in fatigue, endurance, strength, and sleep, it did not lead to a statistically significant change in shortness of breath, nor in depression, anxiety, or stress scores measured by the Depression, Anxiety, and Stress Scale – 21 Items (DASS-21) self-questionnaire. This pattern suggests hydrogen-rich water may be more relevant for fatigue and physical function than for breathing or mood symptoms in this population.
• Muscle strength and functional movement also increased — The study used a chair stand test to measure how many times participants could stand up and sit down in 30 seconds. Those in the hydrogen group improved significantly more than the placebo group, showing better lower-extremity functional capacity. In other contexts, this measure has been linked to balance and fall risk, though those endpoints were not assessed in this trial.
• Sleep quality improved, especially in those already struggling — Among participants who had trouble sleeping, hydrogen water was associated with improvement in sleep scores. Poor sleep and fatigue feed each other, creating a cycle that’s hard to break. Better sleep may interrupt that cycle, giving the body more opportunity for overnight recovery.
• Benefits appeared within the 14-day window — Measurable changes appeared across multiple endpoints, including fatigue, endurance, strength, and sleep, within the two-week intervention. Whether individuals outside the population that was studied would experience similar timing is not established. Larger and longer trials are needed to confirm and extend these findings.

These findings are from research conducted in clinical settings. Results may not apply to all individuals.

Proposed Mechanisms: How Hydrogen May Influence Cellular Energy

The results of the featured study are notable, and the proposed mechanisms are worth understanding. The trial also reported a within-group correlation between reduced fatigue and improved muscle function — participants with the largest fatigue reductions showed the largest strength gains.
This within-trial correlation is consistent with the idea that energy and physical performance reinforce each other, though it’s important to not jump into general conclusions right away. Such a relationship cannot be confirmed from a single small trial.

• Observed effects of hydrogen on oxidative stress — Researchers have proposed that molecular hydrogen acts as a selective antioxidant — preferentially neutralizing the most reactive species, like hydroxyl radicals, while leaving signaling-essential reactive species intact.
For context, hydroxyl radicals are highly reactive and damage almost anything nearby, including proteins, lipids, and DNA. The beneficial reactive species the body uses for immune signaling and cellular communication are more stable, so the proposed model is that hydrogen passes them by. This selective-antioxidant model remains a hypothesis under active investigation.
• Mitochondrial possibilities — Hydrogen has been studied for its potential to influence mitochondrial activity by reducing excess oxidative stress within these structures. When mitochondria function more efficiently, the systems they fuel — including muscles, the brain, and the immune response — have more energy available.
• Inflammatory signaling properties — Hydrogen has also been studied for anti-inflammatory effects. Emerging evidence suggests it may help moderate inflammatory signaling. When chronic inflammation is reduced, energy that has been diverted into inflammatory responses can become available for repair and normal activity.

Practical Approaches for Long-COVID-Related Fatigue

Approaches that aim to support cellular energy production and reduce chronic inflammation are areas of active research for people with persistent post-COVID symptoms. Within this context, the following strategies can be explored:

1. Consider drinking hydrogen-rich water — Some studies have explored whether hydrogen-rich water may help with cellular energy and oxidative stress. Hydrogen tablets are typically dropped into room-temperature water and consumed once fully dissolved (when the water turns cloudy, indicating active hydrogen gas). Tablets producing 8 to 10 parts per million (ppm) with independent purity testing are generally considered preferable.
Also, timing matters. Drink it right away because hydrogen escapes quickly. Don’t swallow the tablet dry or drink partially dissolved pieces, because the reaction produces heat and can damage your tissues. For persistent fatigue, this approach focuses on the cellular-energy hypothesis as one possible target.
2. Patterns of consistent and cycled use are sometimes discussed — Some users adopt a daily-then-cycled pattern to maintain responsiveness, but the optimal regimen has not been established in clinical trials. The protocol in the Nutrients study used twice-daily consumption for 14 days. People who experiment with longer-term use may use it daily during periods of higher fatigue and pause for a few days before resuming. Whether cycling improves outcomes is not clinically established.
3. Spike-protein research is part of the post-COVID conversation — The Nutrients trial focused on cellular energy. In another study, researchers detected vaccine-derived recombinant spike protein in the blood of vaccinated individuals up to 187 days post-vaccination.3 Note that the same paper does not directly establish persistence of infection-derived spike protein, which is the subject of separate ongoing investigation.
Some clinicians and researchers have explored whether proteolytic enzymes — enzymes that break down proteins — might support degradation of circulating proteins. Among proteolytic enzymes, some health care practitioners favor lumbrokinase; rigorous head-to-head clinical comparisons with nattokinase and serrapeptase remain limited.
Proteolytic enzymes are typically taken away from protein-containing meals (commonly an hour before or two hours after) to limit competition with digestive demands. Clinical evidence specifically demonstrating spike-protein-fragment clearance in humans is limited; some individuals report this approach as a complementary strategy when fatigue persists.
4. Structured recovery frameworks are available — Practical resources include the I-RECOVER protocol from the Independent Medical Alliance (formerly known as the Front Line COVID-19 Critical Care Alliance, or FLCCC).4 It covers detox, inflammation control, and mitochondrial repair in a clear sequence. If you feel overwhelmed or unsure where to start, this gives you a defined structure so you can move forward without second-guessing every decision.
5. Cognitive symptoms are sometimes addressed alongside physical recovery — Fatigue can affect cognition as well as physical function. If focus, memory, or mental speed feel off, brain-training tools paired with light physical movement are sometimes used to support neuroplasticity and brain–body coordination. Regular practice is thought to support these pathways over time.

FAQs About Molecular Hydrogen for Long COVID

Q: What did hydrogen-rich water improve in the long-COVID pilot trial?
A: In the cited 14-day pilot trial published in Nutrients, hydrogen-rich water was associated with measurable improvements in fatigue, strength, endurance, and sleep.

Q: How quickly do you start seeing results?
A: The improvements showed up in just 14 days of consistent use. That short timeframe gives you a clear expectation. If your energy system is responding, you would notice changes within weeks, not months. This also makes it easier to track your progress and stay motivated instead of guessing whether something is working.

Q: Why does hydrogen help with fatigue at the root level?
A: Fatigue in long COVID has been associated with disrupted energy production inside cells. Hydrogen has been studied for its potential to reduce oxidative stress and moderate inflammatory signaling, with proposed effects on mitochondrial function. The selective-antioxidant model is currently a hypothesis under active investigation.

Q: Does hydrogen help with all long COVID symptoms?
A: Results in this trial were stronger for fatigue, strength, endurance, and sleep than for shortness of breath. DASS-21 scores also did not show statistically significant improvement. The data support hydrogen-rich water as more relevant to fatigue and physical function than to breathing or mood symptoms in this population.

Q: How does improving energy lead to better physical recovery?
A: Within the trial, participants with the greatest fatigue reductions also showed the largest strength gains. Whether this within-group correlation reflects a generalizable feedback loop between energy and movement requires further study.

This article is for informational purposes only and does not constitute medical advice. Consult a qualified healthcare provider before making changes to your health regimen.

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A compound used in some orally taken weight-loss drugs to help absorption is called:

Salcaprozate sodium (SNAC)
Salcaprozate sodium (SNAC) is added to oral GLP-1 drugs to help them pass through the stomach lining and enter the bloodstream. Learn more.
Sodium bicarbonate (NaHCO₃)
Calcium carbonate (CaCO₃)
Magnesium citrate