Watchman News

By Dr. Mercola

Magnesium is a crucially important mineral for optimal health, performing a wide array of biological functions, including playing an important role in bone health. In fact, of the 25 grams of magnesium found in an average adult, up to 60 percent of it is found in your bones.1
Multiple studies have shown that higher magnesium intake is associated with a higher bone mineral density in both men and women,2 and recent research from Norway has even found an association between magnesium in drinking water and risk of hip fractures.

Magnesium May Lower Your Risk of Hip Fractures

Norway, like the US, has a high rate of hip fractures, but the researchers noted that its incidence varies by region, with those living in urban areas more likely to have hip fractures than those in rural locales. They suggested this could be due to naturally varying levels of minerals like magnesium in the drinking water, although this didn’t turn out to be the case.
What they did find, however, was that while concentrations of magnesium (and calcium) in drinking water were generally low, there was an inverse association between concentration of magnesium and risk of hip fracture in both men and women.3 The researchers concluded:
“Magnesium in drinking water may have a protective role against hip fractures.”

The finding is significant considering how debilitating a hip fracture can be, especially among the elderly. A broken hip carries a great risk of complications and usually requires prolonged specialized care for recovery. It’s estimated that 25 percent of elderly people suffering a hip fracture die as a direct result.4

Magnesium Is Involved in Bone Formation and Health

It’s estimated that 80 percent of Americans are deficient in magnesium, which could have a dramatic influence on bone health. Magnesium influences activities of both osteoblasts (cells responsible for bone formation) and osteoclasts (the cells that break down your bone).
Magnesium is thought to play a role in preventing and fighting osteoporosis.  According to the National Office of Dietary Supplements:5
“Magnesium also affects the concentrations of both parathyroid hormone and the active form of vitamin D, which are major regulators of bone homeostasis… Research has found that women with osteoporosis have lower serum magnesium levels than women with osteopenia and those who do not have osteoporosis or osteopenia. These and other findings indicate that magnesium deficiency might be a risk factor for osteoporosis.”

In fact, one study found that postmenopausal women with osteoporosis were able to suppress bone turnover (which suggests bone loss decreased) just by taking 290 mg/day of magnesium for 30 days.6

Your Calcium-Magnesium Ratio: Are You Taking Too Much Calcium?

Over the past 30 years, women have been told to take supplemental calcium to avoid osteoporosis. Many foods have also been fortified with extra calcium to prevent calcium deficiency among the general population.
Despite such measures, osteoporosis has continued to climb, and this could be, in part, because of an imbalanced calcium-magnesium ratio. According to Carolyn Dean, a medical and naturopathic doctor:
“I’ve heard statistics like a 700 percent rise in osteoporosis in a 10-year period, even while taking all this calcium. The myth that’s been created about calcium is that we need twice as much calcium as we do magnesium. Most of the supplements reflect this. We’ve got a situation where people are taking 1,200 to 1,500 milligrams of calcium and maybe a few hundred milligrams of magnesium.

The 2:1 ratio—that was a mistake; a mistaken translation from French researcher Jean Durlach, who said never ever go beyond two parts calcium to one part magnesium in your food, water, or supplement intake combined.”

This was misinterpreted as meaning a 2:1 ratio was an appropriate ratio, which it’s not. A more appropriate ratio of calcium to magnesium is 1:1. This may not only pose a risk to your bones but also to your heart. If you have too much calcium and not enough magnesium, your muscles will tend to go into spasm. So excessive amounts of calcium without the counterbalance of magnesium can lead to a heart attack and sudden death. Quite simply, with insufficient amounts of magnesium, your heart simply cannot function properly.

For Optimal Bone and Heart Health, You’ve Got to Balance Magnesium with Vitamins K2 and D

When balancing calcium and magnesium also keep in mind that these must be balanced with vitamins K2 and D. These four nutrients perform an intricate dance together, with one supporting the other. Lack of balance between these nutrients is why calcium supplements have become associated with increased risk of heart attacks and stroke, and why some people experience vitamin D toxicity.

Part of the explanation for these adverse side effects is that vitamin K2 keeps calcium in its appropriate place. If you’re K2 deficient, added calcium can cause more problems than it solves, by accumulating in the wrong places, like soft tissue.

Similarly, if you opt for oral vitamin D, you need to also consume it in your food or take supplemental vitamin K2 and more magnesium. Taking mega doses of vitamin D supplements without sufficient amounts of K2 and magnesium can lead to vitamin D toxicity and magnesium deficiency symptoms, which include inappropriate calcification that may damage your heart.

Magnesium and vitamin K2 complement each other, as magnesium helps lower blood pressure, which is an important component of heart disease. So, all in all, anytime you’re taking any of the following: magnesium, calcium, vitamin D3, or vitamin K2, you need to take all the others into consideration as well, since these all work synergistically with one another.

What Else Is Magnesium Good For?

It would be misleading to simply classify magnesium as a mineral for your bones or your heart. Researchers have now detected 3,751 magnesium-binding sites on human proteins, indicating that its role in human health and disease may have been vastly underestimated.7 Magnesium is also found in more than 300 different enzymes in your body and plays a role in your body’s detoxification processes, making it important for helping to prevent damage from environmental chemicals, heavy metals, and other toxins. Even glutathione, your body’s most powerful antioxidant that has even been called “the master antioxidant,” requires magnesium for its synthesis. Recent research also showed that higher intakes of dietary magnesium were associated with a lower risk of colorectal tumors.8 To date more than 100 health benefits of magnesium have been identified so far, including therapeutic benefits for:9

Fibromyalgia
Atrial fibrillation
Type 2 diabetes
Premenstrual syndrome

Cardiovascular disease
Migraine
Aging
Mortality

Watching Out for Symptoms of Magnesium Deficiency

There’s no lab test that will give you a truly accurate reading of the magnesium status in your tissues. Only one percent of the magnesium in your body is distributed in your blood, making a simple sample of magnesium from a blood test highly inaccurate. Some specialty labs do provide an RBC magnesium test, which is reasonably accurate, and other tests that your doctor can use to evaluate your magnesium status include a 24-hour urine test or a sublingual epithelial test. Still, these can only give you an estimation of your levels, and doctors typically need to evaluate them in conjunction with the symptoms you exhibit.

If you suspect you’re not getting enough magnesium, you should keep a watchful eye out for symptoms of deficiency. If you eat a poor diet, including one that’s mostly processed foods, this could apply to you. Further, if any of these conditions below apply to you, you may want to take extra precautions to make sure you’re getting a sufficient amount of magnesium in your diet, or, if needed, from a magnesium supplement, in order to avoid magnesium deficiency. >

An unhealthy digestive system, which impairs your body’s ability to absorb magnesium (Crohn’s disease, leaky gut, etc.)
Alcoholism — up to 60 percent of alcoholics have low blood levels of magnesium10

Unhealthy kidneys, which contribute to excessive loss of magnesium in urine
Age — older adults are more likely to be magnesium deficient because absorption decreases with age and the elderly are more likely to take medications that can interfere with absorption

Diabetes, especially if it’s poorly controlled, may lead to increased magnesium loss in urine
Certain medications — diuretics, antibiotics, and medications used to treat cancer can all result in magnesium deficiency

 
In her book, The Magnesium Miracle, Dr. Dean lists 100 factors that will help you decide whether or not you might be deficient. Early signs of magnesium deficiency to watch out for include loss of appetite, headache, nausea, fatigue, and weakness. An ongoing magnesium deficiency can lead to more serious symptoms, including:

Numbness and tingling Muscle contractions and cramps Seizures

Personality changes Abnormal heart rhythms Coronary spasms

What Are the Best Dietary Sources of Magnesium?

Many people are low in magnesium. In order to ensure you’re getting enough, you first need to be sure you’re eating a varied, whole-food diet like the one described in my nutrition plan. Green leafy vegetables like spinach and Swiss chard are excellent sources of magnesium, as are some beans, nuts, and seeds, like almonds, pumpkin seeds, sunflower seeds, and sesame seeds. Avocados are also a good source. Juicing your vegetables is an excellent option to ensure you’re getting enough of them in your diet.
One important point to mention, though, is that the levels of magnesium in your food are dependent on the levels of magnesium in the soil where they’re grown. Organic foods may have more magnesium, as most fertilizer used on conventional farms relies heavily on nitrogen, phosphorus, and potassium instead of magnesium. Another one of the major benefits of getting your nutrients from a varied whole-food diet is that you’re far less likely to end up with too much of one nutrient at the expense of others. Foods in general contain all the cofactors and needed co-nutrients in the proper amounts for optimal health, which takes out the guesswork. When you’re using supplements, you need to become a bit savvier about how nutrients influence and synergistically affect each other.

In case you’re interested, another way to improve your magnesium status is to take regular Epsom salt baths or foot baths. Epsom salt is a magnesium sulfate that can be absorbed into your body directly through your skin. Magnesium oil (from magnesium chloride) can also be used for topical application and absorption.

The 8 Forms of Magnesium Supplements: What Type Is Best?

If you opt for a magnesium supplement, be aware that there are several different forms of magnesium. The reason for the wide variety of magnesium supplements on the market is because the magnesium must be bound to another substance. There’s no such thing as a 100% magnesium compound supplement (except pico-ionic magnesium). The substance used in any given supplement compound can affect the absorption and bioavailability of the magnesium, and may provide slightly different, or targeted, health benefits. Following is a general guide to help you sort through the eight different formulas you’re likely to come across:

Magnesium glycinate is a chelated form of magnesium that tends to provide the highest levels of absorption and bioavailability and is typically considered ideal for those who are trying to correct a deficiency Magnesium threonate is a newer, emerging type of magnesium supplement that appears promising, primarily due to its superior ability to penetrate the mitochondrial membrane

Magnesium chloride / magnesium lactate contain only 12 percent magnesium, but has better absorption than others, such as magnesium oxide, which contains five times more magnesium Magnesium sulfate / magnesium hydroxide (milk of magnesia) are typically used as a laxative. Be aware that it’s easy to overdose on these, so ONLY take as directed

Magnesium carbonate, which has antacid properties, contains 45 percent magnesium Magnesium taurate contains a combination of magnesium and taurine, an amino acid. Together, they tend to provide a calming effect on your body and mind

Magnesium citrate is magnesium with citric acid, which has laxative properties Magnesium oxide is a non-chelated type of magnesium, bound to negatively charged oxygen (oxide). It contains 60 percent magnesium and has stool-softening properties

By Dr. Mercola

Statin cholesterol-lowering drugs are among the most widely prescribed drugs on the market, bringing in $20 billion a year.1 They are a top profit-maker for the pharmaceutical industry, in part due to relentless and highly successful direct-to-consumer advertising campaigns.
One in four Americans over the age of 45 now takes statins, typically for the primary prevention of heart attacks and strokes. Traditionally, primary prevention usually involves healthy lifestyle choices that support heart health, things like eating right and exercising, yet here we have millions of Americans taking pills instead.
Has anyone unbiased stopped to find out if these drugs are really the best method for heart attack prevention? After all, as researchers noted in the Open Journal of Endocrine and Metabolic Diseases (OJEMD):2

“…naive indiscriminate acceptance of novel mainstream therapies is not always advisable and prudence is required in unearthing harmful, covert side effects.”

This is precisely the task that researchers from Ireland took on by completing an objective review of Pubmed, EM-BASE and Cochrane review databases.3 Their results speak volumes…

“It is beginning to dawn on some clinicians that contemporary treatments are not only failing to impact on our most prevalent diseases, but they may be causing more damage than good. A perfect example of such an issue is the statin saga.”

The Evidence Is In: Lifestyle Trumps Statins for Primary Heart Attack Prevention

For a drug therapy that appears to offer little by way of primary prevention, the risks were alarming. For every 10,000 people taking a statin, there were:

307 extra patients with cataracts
23 additional patients with acute kidney failure
74 extra patients with liver dysfunction

The landmark review revealed “a categorical lack of clinical evidence to support the use of statin therapy in primary prevention.” They also found that statins actually increase cardiovascular risk in women, the young and people with diabetes. The review also showed that statin therapy increased:

Muscle fatigabilty by 30% with more than 11% incidence of rhabdomyolysis (a life-threatening muscle condition) at high doses
Coronary artery and aortic calcification
Erectile dysfunction, which is 10 times more common in young men taking the lowest dose of statin.
Diabetes
Cancer

The researchers noted:

“There is increased risk of diabetes mellitus, cataract formation, and erectile dysfunction in young statin users, all of which are alarming. Furthermore there is a significant increase in the risk of cancer and neurodegenerative disorders in the elderly plus an enhanced risk of a myriad of infectious diseases. All side effects are dose dependent and persist during treatment.

Primary prevention clinical results provoke the possibility of not only the lack of primary cardiovascular protection by statin therapy, but highlight the very real possibility of augmented cardiovascular risk in women, patients with diabetes mellitus and the young. Statins are associated with triple the risk of coronary artery and aortic calcification.

These findings on statins’ major adverse effects had been under-reported and the way in which they [were] withheld from the public, and even concealed, is a scientific farce.

… Cardiovascular primary prevention and regeneration programmes, through life style changes and abstaining from tobacco use have enhanced clinical efficacy and quality of life over any pharmaceutical or other conventional intervention.”

If You Take Statins, Your Vision Could Be at Risk

The featured review found an increased risk of cataracts with statin use, and this was supported by a new JAMA study,4 which further revealed that the risk of cataracts is increased among statin users, compared with non-users. As a main cause of low vision among the elderly, cataract is a clouding of your eye lens.
It has previously been hypothesized that statin antioxidant effects may slow the aging process of the lens, but the current study revealed that they, instead, raise cataract risk, again calling into question the usefulness of statins for primary prevention of heart attacks. The researchers concluded:

“The risk-benefit ratio of statin use, specifically for primary prevention, should be carefully weighed, and further studies are warranted.”

Certain Statins May Impair Your Memory and May Even Lead to Amnesia

Still more research revealed that rats taking the statin Pravachol (pravastatin) had impaired learning, with lower abilities to perform simple learning and memory tasks.5 This isn’t exactly news, as in 2012, the US Food and Drug Administration (FDA) announced it would be requiring additional warning labels for statins, one of which warned that statins may increase the risk of memory loss and confusion. The warnings, particularly the one for memory loss, came as the result of anecdotal reports compiled over the previous year…
Interestingly, the animal study found no association between another statin drug, Lipitor, and impaired memory in the rats. But Dr. Duane Graveline, a medical doctor and former astronaut, has written an entire book on this very topic, titled Lipitor: Thief of Memory.
In my interview with him, Dr. Graveline shared his powerful story about how Lipitor caused him severe global transient amnesia, which is what brought him out of retirement to investigate statins. There have been thousands of cases of transient global amnesia and other types of cognitive damage associated with statin use, reported to the FDA’s MedWatch site. It is believed that statin drugs damage your brain by creating a cholesterol deficiency.
Insufficient cholesterol results in your brain not having the raw materials it needs to make biochemicals critical for memory and cognitive function, including coenzyme Q10 and dolichols, the latter of which carry the genetic instructions from your DNA to help create specific proteins in your body that are crucial for cognitive function, emotions and mood.

High Cholesterol Levels May Be Protective

Any discussion of statins would be incomplete without a discussion of cholesterol – the ‘villain’ that these drugs mercilessly lower. Many buy into the conventional belief that lower cholesterol equals a lower risk of heart disease, but this is not always the case. And, in fact, high cholesterol levels are indeed protective in some cases, whereas low cholesterol levels are very clearly linked to chronic disease. Writing in OJEMD, researchers explained:

“Cholesterol is crucial for energy, immunity, fat metabolism, leptin, thyroid hormone activity, liver related synthesis, stress intolerance, adrenal function, sex hormone syntheses and brain function. When prescribing HMGCoA reductase inhibitors [statins] one needs to be cognizant of the fact that the body had increased its’ cholesterol as a compensatory mechanism and investigate accordingly.

We seem to have fallen into the marketing trap and ignored the niggling side effects with regard to the HMGCoA reductase inhibitors. The only statin benefit that has actually been demonstrated is in middle-aged men with coronary heart disease. However, statins were not shown to best form of primary prevention.

… In actual fact, high cholesterol levels have been found to be protective in elderly and heart failure patients and hypo-cholestereamic [low cholesterol] patients had higher incidence of intra-cerebral bleeds, depression and cancer. … We are observing the revealing of the utmost medical tragedy of all time. It is unprecedented that the healthcare industry has inadvertently induced life-threatening nutrient deficiency in millions of otherwise healthy people. What is even more disparaging is that not only has there been a failure to report on these negative side-effects of statins, there has actually been active discouragement to publish any negative studies on statins.”

This is, in large part, why so many people are completely unaware that statin drugs have been directly linked to over 300 side effects,6 which include:

Cognitive loss
Neuropathy

Anemia

Acidosis

Frequent fevers

Cataracts

Sexual dysfunction

An increase in cancer risk

Pancreatic dysfunction

Immune system suppression

Muscle problems, polyneuropathy (nerve damage in the hands and feet), and rhabdomyolysis, a serious degenerative muscle tissue condition

Hepatic dysfunction. (Due to the potential increase in liver enzymes, patients must be monitored for normal liver function)

Ask Yourself – and Your informed Physician — if You Really Need to Be Taking Statins

I’ve long stated that the odds are very high — greater than 100 to 1 — that if you’re taking a statin, you may not even need it, as cholesterol is NOT the cause of heart disease. To further reinforce the importance of cholesterol, I want to remind you of the work of Dr. Stephanie Seneff, who works with the Weston A. Price Foundation.

One of her theories is that cholesterol combines with sulfur to form cholesterol sulfate, and that this cholesterol sulfate helps thin your blood by serving as a reservoir for the electron donations you receive when walking barefoot on the Earth (also called grounding). She believes that, via this blood-thinning mechanism, cholesterol sulfate may provide natural protection against heart disease.

In fact, she goes so far as to hypothesize that heart disease is likely the result of cholesterol deficiency — which of course is the complete opposite of the conventional view. So if your physician is urging you to check your total cholesterol, know that this test will tell you virtually nothing about your risk of heart disease, unless it is 330 or higher. HDL percentage is a far more potent indicator for heart disease risk. Here are the two ratios you should pay attention to:

HDL/Total Cholesterol Ratio: Should ideally be above 24 percent. If below 10 percent, you have a significantly elevated risk for heart disease.
Triglyceride/HDL Ratio: Should be below 2.

Additional risk factors for heart disease include:

Your fasting insulin level: Any meal or snack high in carbohydrates like fructose and refined grains generates a rapid rise in blood glucose and then insulin to compensate for the rise in blood sugar. The insulin released from eating too many carbs promotes fat production and makes it more difficult for your body to shed excess weight, and excess fat, particularly around your belly, is one of the major contributors to heart disease
Your fasting blood sugar level: Studies have shown that people with a fasting blood sugar level of 100-125 mg/dl had a nearly 300 percent increase higher risk of having coronary heart disease than people with a level below 79 mg/dl
Your iron level: Iron can be a very potent oxidative stress, so if you have excess iron levels you can damage your blood vessels and increase your risk of heart disease. Ideally, you should monitor your ferritin levels and make sure they are not much above 80 ng/ml. The simplest way to lower them if they are elevated is to donate your blood. If that is not possible you can have a therapeutic phlebotomy and that will effectively eliminate the excess iron from your body

Try This Instead for Primary Heart Attack Prevention

Make no mistake about it, statin drugs are some of the most side effect-ridden medications on the market, and they frequently do more harm than good. Of utmost importance, statins deplete your body of CoQ10, which accounts for many of its devastating results. Therefore, if you take a statin, you MUST take supplemental CoQ10, or better, the reduced form called ubiquinol. If you are interested in optimizing your cholesterol levels (which doesn’t necessarily mean lowering them) and lowering your risk of heart disease and heart attacks, there are natural strategies available for doing so.

Reduce, with the plan of eliminating, grains and sugars in your diet, replacing them with mostly whole, fresh vegetable carbs and healthy fats. Also try to consume a good portion of your food raw.
Make sure you are getting enough high-quality, animal-based omega-3 fats, such as krill oil.
Other heart-healthy foods include olive oil, coconut and coconut oil, organic raw dairy products and eggs, avocados, raw nuts and seeds, and organic grass-fed meats.
Optimize your vitamin D levels.
Exercise daily, especially with high-intensity interval training (HIIT) exercises.
Avoid smoking or drinking alcohol excessively.
Be sure to get plenty of good, restorative sleep.

By Dr. Mercola

In 2004, the US government’s National Cholesterol Education Program panel advised those at risk for heart disease to attempt to reduce their LDL cholesterol to less than 100, or even less than 70, if you’re very high risk. Prior to this, a 130-milligram LDL cholesterol level was considered healthy.

In order to obtain the incredibly low LDL levels now recommended, you typically have to take a cholesterol-lowering statin drug, and sometimes two or three of them in combination.

Now, a new class of cholesterol drugs known as PCSK9 inhibitors promises to reduce LDL cholesterol levels to previously unheard of lows. Indeed, this type of drug can drop your level below 50!

My prediction? These drugs will absolutely kill people—not just some, but MANY. I cannot warn you against this terrible idea enough. While many worry that their cholesterol is too high, few give any thought at all to the damage that can result if your cholesterol is too low.

This is a topic near and dear to my heart, as I drove (without drugs) my own total cholesterol levels down to a risky 75 when I was a naive young doctor. Alas, when it comes to cholesterol, lower is not always better. In fact, when your cholesterol levels go too low, a host of negative things happen in your body.

Unfortunately, lowering cholesterol levels has become so common in the US that nearly every American reading this either knows someone struggling to do so, or has struggled to do so themselves.

This despite the fact that there is no evidence to support the notion that having an extremely low cholesterol level is beneficial, and increasing numbers of studies point to significant risks associated with cholesterol-lowering drugs.

For example, a 2008 paper published in the American Journal of Cardiovascular Drugs1 cites nearly 900 studies on the adverse effects of HMG-CoA reductase inhibitors (statins), which run the gamut from muscle problems to increased cancer risk.

How Do PCSK9 Inhibitors Work?

Whereas statins (HMG-CoA reductase inhibitors) reduce your cholesterol by blocking an enzyme in your liver that is responsible for making cholesterol, these newer drugs, PCSK9 inhibitors, target and suppress a particular gene involved in the regulation of how much cholesterol your liver can actually filter out.

Researchers discovered that people with underactive PCSK9 genes had low levels of LDL. They also had low levels of cardiovascular disease. Since high cholesterol has long been mistaken as a primary cause of cardiovascular disease, these findings were akin to striking scientific gold… As reported in the featured article2:

“It’s this discovery that has Sanofi and two other major drug companies, Amgen and Pfizer, racing to develop a drug that mimics the gene’s effects. The best approach, experts say, will be through monoclonal antibodies: antibodies that are created in a lab and help your immune system fight a disease or, in this case, fight cholesterol…

‘This is not to replace statin therapy,’ said Joe Miletich, senior vice president of research and development at Amgen. ‘This is actually to get patients to (their) goal who can’t get there.’… ‘With a statin medication, you can often get somebody’s cholesterol between 70 and 100 mg/dL,’ said Dr. Elliott Antman, president-elect of the American Heart Association and a dean at Harvard Medical School. ‘If you use these monoclonal antibodies, you could see a number way less than 50.'”

I’ve told you before that the odds are very high— greater than 100 to 1—that if you’re taking a statin, you don’t really need it. From my review, the only subgroup that might benefit are those born with a genetic defect called familial hypercholesterolemia, as this makes them resistant to traditional measures of normalizing cholesterol.
In my view, this warning is just as applicable when it comes to PCSK9 inhibitors. Your body needs cholesterol and it doesn’t matter how you lower it: statins, PCSK inhibitors, or diet and exercise like I did. If your cholesterol drops too low, you will suffer health problems that I review in the next section.

The Health Hazards of Having Too Little Cholesterol

Your body needs cholesterol for the production of cell membranes, hormones, vitamin D, and bile acids that help you to digest fat. It’s not hard to see then why too little cholesterol can have such detrimental effects on your body—especially your brain, where it helps your brain form memories and is vital to your neurological function.

For example, research published in 20083 showed that low HDL is associated with poor memory and decline in memory in middle-aged adults. If you value your brain and want to keep it functioning into your senior years, you’d be well advised to pay attention to what it needs, and that includes cholesterol, along with healthful fats like omega-3. But impaired memory and dementia are just the tip of the iceberg when it comes to low cholesterol’s impact on your brain. If your levels get too low, you also increase your risk of:

Violent behavior and aggression
Depression
Suicide
Cancer4
Parkinson’s disease

Even more importantly, heart disease may in fact be a sign of cholesterol deficiency, according to MIT researcher, Dr. Stephanie Seneff. Considering the fact that conventional medicine has been telling us that heart disease is due to elevated cholesterol and recommends lowering cholesterol levels as much as possible, Dr. Seneff’s claims may come as a complete shock to some.

“Heart disease, I think, is a cholesterol deficiency problem, and in particular a cholesterol sulfate deficiency problem…”

She points out that all of this information is available in the research literature, but it requires putting all the pieces together to see the full picture. Through her research, she believes that the mechanism we call “cardiovascular disease,” of which arterial plaque is a hallmark, is actually your body’s way to compensate for not having enough cholesterol sulfate. In a nutshell, high LDL appears to be a sign of cholesterol sulfate deficiency—it’s your body’s way of trying to maintain the correct balance by taking damaged LDL and turning it into plaque, within which the blood platelets produce the cholesterol sulfate your heart and brain needs for optimal function…

What this also means is that when you artificially lower your cholesterol with a statin drug, which effectively reduces that plaque but doesn’t address the root problem, your body is not able to compensate any longer, and as a result of lack of cholesterol sulfate you may end up with heart failure.

Have High Cholesterol? Address the Cause!

Contrary to popular belief, high cholesterol is not a disease in and of itself. It is actually a response to something gone awry in your body. Cholesterol is produced whenever your cells become damaged, as it’s a necessary component in making new, healthy cells, so if you have a lot of damaged cells, you’re also going to have a lot of cholesterol in your bloodstream. This is a sign that your cells need, and are, being repaired. While most conventional doctors do not recognize this sign for what it is and put you on toxic cholesterol-lowering drugs, a more knowledgeable doctor will address the root problem, which is typically related to chronic inflammation brought on by:

A diet too high in sugar/fructose and grains
Too many processed, overcooked foods
Lack of exercise
Emotional stress
Smoking

The remedy involves, of course, addressing these factors by making simple lifestyle changes that are outlined in my optimized nutrition and lifestyle plan. Whatever you do, don’t fall for the mistaken belief that the lower your cholesterol goes, the better. If you lower your cholesterol through artificial means without addressing the underlying causes for your elevated cholesterol levels, your body will continue to degenerate. Leave the decision of how much cholesterol your body needs up to your body, and make the right lifestyle choices to keep your cells in their top condition. This way you get the best of both worlds: the right amount of cholesterol and a body in tip-top shape.

The Many Well-Known Health Hazards of Statin Drugs

First, if you are a woman, it’s critical for you to know that statins are classified as a “pregnancy Category X medication” meaning, it causes serious birth defects, and should NEVER be used if you’re pregnant or planning a pregnancy. Last year, the US Food and Drug Administration5 (FDA) also announced it’s considering additional warning labels for statin drugs. Among them are warnings that statins may increase your risk of:

Liver damage
Memory loss and confusion
Type 2 diabetes
Muscle weakness (for certain statins)

In all, statin drugs have been directly linked to over 300 side effects6, including:

Cognitive loss
Neuropathy
Anemia

Acidosis
Frequent fevers
Cataracts

Sexual dysfunction
An increase in cancer risk
Pancreatic dysfunction

Immune system suppression
Muscle problems, polyneuropathy (nerve damage in the hands and feet), and rhabdomyolysis, a serious degenerative muscle tissue condition
Hepatic dysfunction (Due to the potential increase in liver enzymes, patients must be monitored for normal liver function)

Statins Cause Hallmark Symptoms of Heart Disease and Diabetes

Sadly, while millions of people are told to use statin drugs as a form of “preventive medicine” to protect their heart health, research shows that these drugs actually can have significantly detrimental effects on your heart! How is that preventive medicine? For example, a study published just last year in the journal Atherosclerosis7 showed that statin use is associated with a 52 percent increased prevalence and extent of calcified coronary plaque compared to non-users. And coronary artery calcification is the hallmark of potentially lethal heart disease!

Statins can also:

Deplete your body of CoQ10, which accounts for many of its devastating health effects. CoQ10 is used by every cell in your body, but especially your heart cells. Cardiac muscle cells have up to 200 times more mitochondria, and hence 200 times higher CoQ10 requirements than skeletal muscle. Therefore, if you take a statin, you must take supplemental CoQ10, or better, the reduced form called ubiquinol.

A recent study in the European Journal of Pharmacology8 showed that ubiquinol effectively rescued cells from the damage caused by the statin drug simvastatin, thereby protecting muscle cells from myopathies. Again demonstrating the necessity of CoQ10 supplementation during statin therapy, a recent study9 evaluating the benefits of CoQ10 and selenium supplementation for patients with statin-associated myopathy found that, compared to those given a placebo, the treatment group experienced significantly less pain, decreased muscle weakness and cramps, and less fatigue.
Interfere with the mevalonate pathway, which is the central pathway for the steroid management in your body. Products of this pathway that are negatively affected by statins include sex hormones, cortisone, the dolichols (which are involved in keeping the membranes inside your cells healthy), and all sterols, including cholesterol and vitamin D (which is similar to cholesterol and is produced from cholesterol in your skin).
Increase your insulin resistance, which contributes to chronic inflammation in your body. Increased insulin resistance can lead to heart disease, which, ironically, is the primary reason for taking a cholesterol-reducing drug in the first place. It can also promote belly fat, high blood pressure, heart attacks, chronic fatigue, thyroid disruption, and diseases like Parkinson’s, Alzheimer’s, and cancer.
Increase your risk of diabetes by raising your blood sugar. When you eat a meal that contains starches and sugar, some of the excess sugar goes to your liver, which then stores it away as cholesterol and triglycerides. Statins work by preventing your liver from making cholesterol. As a result, your liver returns the sugar to your bloodstream, which raises your blood sugar levels.
Drug-induced diabetes and genuine type 2 diabetes are not necessarily identical. If you’re on a statin drug and find that your blood glucose is elevated, it’s possible that what you have is just hyperglycemia—a side effect, and the result of your medication. Unfortunately, many doctors will at that point mistakenly diagnose you with “type 2 diabetes,” and possibly prescribe another drug, when all you may need to do is simply discontinue the statin in order for your blood glucose levels to revert back to normal.

Beware: Statins Can Also Completely Negate Your Fitness Efforts

One of the major benefits of exercise is the beneficial impact it has on your heart health, and exercise is a primary strategy to naturally maintain healthy cholesterol levels. Alas, researchers recently discovered that if you take a statin drug, you’re likely to forfeit most if not all health benefits of your exercise. In fact, the study, published in the Journal of the American College of Cardiology10, discovered that statin use led to dramatically reduced fitness benefits from exercise, in some cases actually making the volunteer LESS fit than before!

The key to understanding why statins prevent your body from reaping the normal benefits from exercise lies in understanding what these drugs do to your mitochondria—the energy chamber of your cells, responsible for the utilization of energy for all metabolic functions. As mentioned above, the primary fuel for your mitochondria is Coenzyme Q10 (CoQ10), and one of the primary mechanisms of harm from statins in general appears to be related to CoQ10 depletion.

A 2011 review published in Applied Physiology, Nutrition and Metabolism11 pointed out that exercise actually induces changes in mitochondrial enzyme content and activity, which can increase your cellular energy production and in so doing decrease your risk of chronic disease. The fact that statin drugs deplete your body of the primary fuel for your mitochondria helps explain why certain statin users in the trial ended up with worse aerobic fitness after a steady fitness regimen. There simply wasn’t enough mitochondrial fuel in their system.

To Evaluate Your Heart Disease Risk, Get the Right Tests Done

If your physician is urging you to check your total cholesterol, then you need to be aware that this test will tell you virtually nothing about your risk of heart disease, unless it is 330 or higher.

One of the most important tests you can get to determine your real heart disease risk is the NMR LipoProfile, which measures your LDL particle number. This test also has other markers that can help determine if you have insulin resistance, which is a primary cause of elevated LDL particle number and increased heart disease risk. The NMR LipoProfile test easy to get and all major labs offer it. Most insurance policies cover the test as well. Best of all, even if your doctor were to refuse to order it, you can order it yourself via third-party intermediaries like Direct Labs, or you can order the test online, and get blood drawn locally. Two other ratios you should pay attention to are your:

HDL/Total Cholesterol Ratio: (i.e. take your HDL number and divide it by your total cholesterol number.) This should ideally be above 24 percent. If below 10 percent, you have a significantly elevated risk for heart disease.
Triglyceride/HDL Ratio: Should be below 2.

I have seen a number of people with total cholesterol levels over 250 who were actually at low risk for heart disease due to their elevated HDL levels. Conversely, I have seen many people with cholesterol levels under 200 who had a very high risk of heart disease, based on their low HDL. For four additional risk factors for heart disease that do not involve your cholesterol levels, please see my recent article: Side Effects of Statins.

How to Optimize Your Cholesterol Levels Naturally

The most effective way to optimize your cholesterol profile and prevent heart disease is via diet and exercise. Seventy-five percent of your cholesterol is produced by your liver, which is influenced by your insulin levels. Therefore, if you optimize your insulin level, you will automatically optimize your cholesterol and reduce your risk of both diabetes and heart disease.

There is NO drug that can cure heart disease, as the underlying cause is insulin and leptin resistance and arterial wall damage—both of which are caused by eating excessive amounts of sugars, grains, and especially fructose. So, in addition to regular exercise, my primary recommendations for safely regulating your cholesterol and reducing your risk of heart disease include:

Reduce, with the plan of eliminating grains and fructose from your diet. This is one of the best ways to optimize your insulin levels, which will have a positive effect on not just your cholesterol, but also reduces your risk of diabetes and heart disease, and most other chronic diseases. Use my Nutrition Plan to help you determine the ideal diet for you, and consume a good portion of your food raw.
Start intermittent fasting, which will radically improve your ability to burn fat as your primary fuel and thus help improve your insulin and leptin signaling.
Get plenty of high-quality, animal-based omega 3 fats, such as krill oil, and reduce your consumption of damaged omega-6 fats (trans fats, vegetable oils) to balance out your omega-3 to omega-6 ratio.
Include heart-healthy foods in your diet, such as olive oil, coconut and coconut oil, organic raw dairy products and eggs, avocados, raw nuts and seeds, and organic grass-fed meats.
Optimize your vitamin D levels by getting proper sun exposure or using a safe tanning bed.
Optimize your gut flora, as recent research suggests the bacterial balance in your intestines may play a role in your susceptibility to heart disease as well.
Walk barefoot to ground yourself to the earth. Lack of grounding has a lot to do with the rise of modern diseases as it affects inflammatory processes in your body. Grounding thins your blood, making it less viscous. Virtually, every aspect of cardiovascular disease has been correlated with elevated blood viscosity.

When you ground to the earth, your zeta potential quickly rises, which means your red blood cells have more charge on their surface, which forces them apart from each other. This action causes your blood to thin and flow easier. By repelling each other, your red blood cells are also less inclined to stick together and form a clot.

Avoid smoking or drinking alcohol excessively.
Be sure to get plenty of good, restorative sleep.

Take Control of Your Health

The odds are very high that if you’re taking cholesterol-lowering medication, you’re wasting your money and taking unnecessary risks with your health. From my review, the ONLY subgroup that might benefit from statins are those born with a genetic defect called familial hypercholesterolemia, as this makes them resistant to traditional measures of normalizing cholesterol, which I reviewed above.

Remember, your body needs cholesterol for the production of cell membranes, hormones, and vitamin D, just to mention a few. Cholesterol is also vital to your neurological function. And there’s strong evidence that having too little cholesterol increases your risk for cancer, memory loss, Parkinson’s disease, hormonal imbalances, stroke, depression, suicide, and violent behavior.

Taking a drug that can reduce your cholesterol levels down to 50 or below is absolutely a recipe for disaster, when you consider all your biological functions that need cholesterol!

Also keep in mind that contrary to what you’ve been told by pharmaceutical PR firms, statins have nothing to do with reducing your heart disease risk. In fact, this class of drugs can increase your heart disease risk—especially if you do not take Ubiquinol (CoQ10) along with it to mitigate the depletion of CoQ10 caused by the drug. So please, carefully weigh the risks and benefits!

Poor lifestyle choices are primarily to blame for elevated cholesterol levels, such as too much sugar, too little exercise, lack of sun exposure and never grounding to the earth. These are all things that are within your control, and don’t cost much (if any) money to address. If you have a genetic defect, medication may be needed. If you don’t, you may be surprised at how quickly and easily your cholesterol levels will normalize when you start implementing the required lifestyle changes.

If you’re currently taking a statin drug and are worried about the excessive side effects they cause, please consult with a knowledgeable health care practitioner who can help you to optimize your heart health naturally, without the use of these dangerous drugs. To learn more about statins, please see my special report: “Do YOU Take Any of These 11 Dangerous Cholesterol Drugs”?

By Dr. Mercola

Urine can reveal important information about your body’s waste elimination process, providing clues about your overall health status.

Your kidneys serve to filter excess water and water-soluble wastes out of your blood, getting rid of toxins and things that would otherwise build up and cause you to become ill. Many things — from excess protein and sugar to bacteria and yeast — may make their way into your urine.

Instead of ignoring your urine and dashing back to whatever important activity having to pee interrupted, take this golden opportunity to become familiar with your “normal.”

If you notice changes in the way your urine looks or smells, the cause might be something as benign as what you had for dinner last night, such as beets or asparagus. Or, your astuteness may potentially alert you to a serious condition.

If you suspect you have a urinary tract problem, you should consult your physician. One of the first things he or she is likely to do is a urine test. Urine tests have been around for more than 6,000 years1 and are easy, noninvasive tools for quickly assessing your health status2.

Minding Your Pees and Cues

In your lifetime, your kidneys filter more than one million gallons of water, enough to fill a small lake. Amazingly, one kidney can handle the task perfectly well. In fact, if you lose a kidney, your remaining kidney can increase in size by 50 percent within two months, to take over the job of both.3

Urine is 95 percent water and five percent urea, uric acid, minerals, salts, enzymes, and various substances that would cause problems if allowed to accumulate in your body4. Normal urine is clear and has a straw yellow color, caused by a bile pigment called urobilin.

As with your stool, your urine changes color depending on what foods you eat, what medications and supplements you take, how much water you drink, how active you are, and the time of the day.

But some diseases can also change the color and other characteristics of your urine, so it’s important to be alert and informed. With so many variables, you can’t always be sure of what’s causing any particular urine characteristic, short of laboratory testing. However, urine’s character gives you some clues to potential problems that may be developing, giving you time to do something about it.
The following chart outlines some of the most common color variations for urine and their possible origins. The majority of the time, color changes resulting from foods, medications, supplements, or simply dehydration. But there are certain signs that warrant concern.

Color
Possible Cause

Necessary Action

Yellow/Gold

The most typical urine color, indicative of a healthy urinary tract; yellow will intensify depending on hydration; some B vitamins cause bright yellow urine

None

Red/Pink

Hematuria (fresh blood in the urine) related to urinary tract infection (UTI), kidney stone, or rarely cancer; consumption of red foods such as beets, blueberries, red food dyes, rhubarb; iron supplements; Pepto-Bismol, Maalox, and a variety of other drugs5; classic “port wine” color may indicate porphyria (genetic disorder)

***Consult your physician immediately if you suspect you have blood in your urine

White/Colorless

Excessive hydration is most likely. (See Cloudy)

Consult your physician only if chronic

Orange

Typically a sign of dehydration, showing up earlier than thirst; “holding your bladder” for too long; post-exercise; consuming orange foods (carrots, squash, or food dyes); the drug Pyridium (phenazopyridine); liver or pituitary problem (ADH, or antidiuretic hormone)

Drink more water and don’t delay urination; consult physician if orange urine persists despite adequate hydration

Amber

More concentrated than orange so severe dehydration related to intense exercise or heat; excess caffeine or salt; hematuria; decreased urine production (oliguria or anuria); metabolic problem; pituitary problem (ADH, or antidiuretic hormone)

Consult your physician if problem persists despite adequate hydration

Brown

Very dense urine concentration, extreme dehydration; consumption of fava beans; melanuria (too many particles in urine); UTI; kidney stone; kidney tumor or blood clot; Addison’s disease; glycosuria; renal artery stenosis; proteinuria; pituitary problem (ADH, or antidiuretic hormone)

Consult your physician if problem persists despite adequate hydration, especially if accompanied by pale stools or yellow skin or eyes

Black

RARE: Alkaptonuria, a genetic disorder of phenylalanine and tyrosine metabolism marked by accumulation of homogentisic acid in the blood; poisoning

Consult your physician

Green

RARE: Unusual UTIs and certain foods (such as asparagus); excessive vitamins

Usually benign; consult your physician if it persists, especially if you have pain or burning (dysuria), and/or frequent urination (polyuria), which are symptoms of UTI

Blue

RARE: Artificial colors in foods or drugs; bilirubin; medications such as methylene blue; unusual UTIs

Usually benign; consult your physician if it persists, especially if you have pain or burning (dysuria), and/or frequent urination (polyuria), which are symptoms of UTI

Cloudy

Urinary tract infection, kidney problem, metabolic problem, or chyluria (lymph fluid in the urine), phosphaturia (phosphate crystals), pituitary problem (ADH, or antidiuretic hormone)

Consult physician, especially if you have pain or burning (dysuria), and/or frequent urination (polyuria), which are symptoms of UTI

Sediment

Proteinuria (protein particles) or albuminuria; UTI; kidney stones; see Cloudy

Consult your physician

Foamy

Turbulent urine stream; proteinuria (most common causes are diabetes and hypertension)

Consult physician if not due to “turbulence”

Does Your Urine Smell Like Roses?

If you’re a woman from ancient Rome and your urine smells like roses, you’ve probably been drinking turpentine. This is a high price to pay to woo your suitor with pleasant-smelling pee, as turpentine may kill you! Short of drinking turpentine, there are many common substances that may alter the way your urine smells, which is why it’s helpful to know what’s normal. Urine reflects all of the inner workings of your body and contains a wide variety of compounds and metabolic by-products. Some dogs can actually “smell cancer” in human urine6.

Urine doesn’t typically have a strong smell, but if yours smells pungent (like ammonia), you could have an infection or urinary stones, or you may simply be dehydrated. Dehydration causes your urine to be more concentrated and may have a stronger smell than normal, as do high-protein foods like meat and eggs. Menopause, some sexually transmitted diseases, and certain metabolic disorders may also increase the ammonia smell7. Here are some of the more common reasons your urine’s odor may change:

Medications or supplements
Certain genetic conditions, such as Maple Syrup Urine Disease, which causes urine to smell sickeningly sweet8
Certain foods — most notably asparagus. Asparagus is notorious for causing a foul, eggy or “cabbagy” stench that results from a sulfur compound called methyl mercaptan (also found in garlic and skunk secretions). Only 50 percent of people can smell asparagus pee because they have the required gene. Cutting off the tips of asparagus will reportedly prevent the pungent-smelling pee…but of course, this is the tastiest part!
Urinary tract infections
Uncontrolled diabetes is known to cause your urine to have a sweet or fruity or, less commonly, a yeasty smell. In the past, doctors diagnosed diabetes by pouring urine into sand to see if it was sweet enough to attract bugs. Other physicians just dipped a finger in and took a taste. Fortunately, today’s physicians have access to far more elegant diagnostic tools.

When You Feel the Urge to Go, GO

Urinary frequency is also important. Peeing six to eight times per day is “average.” You might go more or less often than that, depending on how much water you drink and how active you are. Increased frequency can be caused by an overactive bladder (involuntary contractions), caffeine, a urinary tract infection (UTI), interstitial cystitis, benign prostate enlargement, diabetes, or one of a handful of neurological diseases.9

It is important to pee when you feel the urge. Delaying urination can cause bladder overdistension — like overstretching a Slinky such that it can’t bounce back. You may habitually postpone urination if you find bathroom breaks inconvenient at work, or if you have Paruresis (also known as Shy Bladder Syndrome, Bashful Bladder, Tinkle Terror, or Pee Anxiety), the fear of urinating in the presence of others. Seven percent of the public suffers from this condition.10

How Much Water Should You Drink?

I don’t subscribe to the commonly quoted rule of drinking six to eight glasses of water every day. Your body is capable of telling you what it needs and when it needs it. Once your body has lost one to two percent of its total water, your thirst mechanism kicks in to let you know it’s time to drink — so thirst should be your guide. Or course, if you are outside on a hot, dry day or exercising vigorously, you’ll require more water than usual — but even then, drinking when you feel thirsty will allow you to remain hydrated.

As you age, your thirst mechanism tends to work less efficiently. Therefore, older adults will want to be sure to drink water regularly, in sufficient quantity to maintain pale yellow urine. As long as you aren’t taking riboflavin (vitamin B2, found in most multivitamins), which turns urine bright “fluorescent” yellow, then your urine should be quite pale. If you have kidney or bladder stones or a urinary tract infection, increase your water intake accordingly.

You and Your Urinary System

You should now have a pretty good idea of how important it is to familiarize yourself with what’s normal for your pee. Urine is a window into the inner workings of your body and can function as an “early warning system” for detecting health problems.

The most important factor in the overall health of your urinary tract is drinking plenty of pure, fresh water every day. Inadequate hydration is the number one risk factor for kidney stones, as well as being important for preventing UTIs. To avoid overly frequent bathroom breaks, stay hydrated but not overhydrated. Drink whenever you’re thirsty, but don’t feel you have to drink eight glasses of water per day, every day. If you’re getting up during the night to pee, stop drinking three to four hours before bedtime.

Limit your caffeine and alcohol intake, which can irritate the lining of your bladder. Make sure your diet has plenty of magnesium, and avoid sugar (including fructose and soda) and non-fermented soy products due to their oxalate content. Finally, don’t hold it. As soon as you feel the urge to go, go! Delaying urination is detrimental to the health of your bladder due to overdistension.